A5029940259- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- Inhalation and Respiratory Drug Delivery
- Mesenchymal stem cell research
- Child Welfare and Adoption
- Cancer-related molecular mechanisms research
- Healthcare Systems and Reforms
- Diabetes Management and Research
- RNA modifications and cancer
- Tracheal and airway disorders
- Cancer therapeutics and mechanisms
- Homelessness and Social Issues
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Gastric Cancer Management and Outcomes
- Influenza Virus Research Studies
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
Jiangsu Provincial Center for Disease Control and Prevention
2016-2025
Wenzhou Medical University
2024
Nanjing Medical University
2016-2024
Putian University
2023
Weatherford College
2023
The First People’s Hospital of Lianyungang
2023
University of Lübeck
2020
German Center for Infection Research
2020
Karolinska Institutet
2020
Pulmonary Associates
2020
Tuberculosis (TB) patients have difficulty following a long-term treatment regimen. Efforts to improve outcomes require better understanding of adherence as complex behavioral issue and the particular barriers facilitators patient adherence.This study was carried out in Jiangsu Province China with both quantitative qualitative approaches. For study, 780 sputum-smear positive TB consecutively registered since 2006 13 counties (districts) were queried structured questionnaire. Patients who had...
Abstract Background The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates inflammatory response, leading persistent systemic response syndrome pulmonary infection in animals There are currently no specific treatment strategies for influenza. Methods We hypothesized that mesenchymal stromal cells (MSCs) would have...
People who are incarcerated at high risk of developing tuberculosis. We aimed to estimate the annual global, regional, and national incidence tuberculosis among populations from 2000 2019.
Abstract The coronavirus disease 2019 (COVID-19) pandemic may impede global tuberculosis elimination goals. In Jiangsu Province, China, notifications dropped 52% in 2020 compared to 2015–2019. Treatment completion and screening for drug resistance decreased continuously 2020. Urgent attention must be paid control efforts during after the COVID-19 pandemic.
Objectives To disclose the associated risk factors for latent tuberculosis infection (LTBI) and current situation of LTBI in eastern China. Methods A cross-sectional study was undertaken to evaluate rate factors. Results total 5305 subjects were finally included, with IGRA positive 19.98% (1060/5305). The rates increasing age (ORs significance from 6.60 20.92). Male gender significantly increased by 0.52 fold (OR = 1.52). Both smoking drinking 1.83 OR 1.67, respectively). Meanwhile,...
Several cohort studies demonstrate that diabetics are at increased risk for active tuberculosis, and poor glycemic control may exacerbate this risk. A higher prevalence of tuberculosis infection baseline among partially explain these results; however, no population-based have investigated association. Furthermore, whether modifies the relationship between diabetes infection, as it does with is unknown. Diabetics were diagnosed through physician evaluation using 3 laboratory tests including...
Background Nontuberculous mycobacteria (NTM) have been reported to be increasing worldwide and its geographic distribution differs by region. The aim of this study was describe the epidemiology NTM in eastern part China. Methods Sputum samples were collected from 30 surveillance sites for tuberculosis drug resistance test May 1, 2008 December 31, 2008. Identification performed using a biochemical test, multiplex PCR GenoType Mycobacterium CM/AS assay. Results A total 1779 smear positive...
The association between smoking exposure and latent tuberculosis infection (LTBI) has been investigated in a few studies; however, further investigation is needed. In this study, the 2011–2012 NHANES population was used to evaluate LTBI risk. A total of 7042 participants with available results without active were included for analysis. Smoking defined as who smoked at least 100 cigarettes their life. Both univariable multivariable analysis adopted exposure, well related factors on risk LTBI....
The management of multidrug-resistant tuberculosis (MDR-TB) remains challenging. Treatment outcome is influenced by multiple factors; the specific roles diabetes and glycemic control remain uncertain. This study aims to assess impact on drug exposure, investigate association between exposure treatment outcomes, identify clinically significant thresholds predictive outcome, among patients with diabetes.
To our knowledge, this is the first head-to-head study to evaluate QuantiFERON-TB Gold Plus, In-Tube, ESAT6-CFP10, and tuberculin skin test among adolescents. Our highlights value of QFT-Plus in detecting Mtb infection high school freshmen when compared QFT-GIT. No studies have simultaneously performances In-Tube (QFT-GIT), Plus (QFT-Plus), ESAT6-CFP10 (EC) test, Tuberculin (TST) This aimed conduct a comparative assessment QFT-GIT for Mycobacterium tuberculosis(Mtb) freshmen. We concurrently...
Introduction No direct comparative study assessing QuantiFERON-TB Gold In-Tube (QFT-GIT) and Plus (QFT-Plus) for Mycobacterium tuberculosis infection among persons living with HIV (PLHIV) in China has been conducted. Methods Simultaneous QFT-GIT QFT-Plus tests were conducted on PLHIV a prison hospital. Positivity negativity results from both assays compared, their diagnostic agreement was assessed. Results A total of 232 individuals included this study. Among them, 57 patients (24.6%) 56...
Abstract Background Drug-resistant tuberculosis (TB) has emerged as a major challenge toward TB control and prevention. In Lianyungang city, the extent trend of drug resistant is not well known. The objective survey was to assess resistance pattern MTB risk factors for TB, including multidrug (MDR-TB) in this area. Methods We performed susceptibility testing on Mycobacterium (MTB) isolates with first- second-line anti-tuberculosis drugs 1012 culture positive cases by using proportion method,...
Few prospective cohort studies, none in China, have investigated the relationship between treatment outcomes of multidrug-resistant tuberculosis (MDR-TB) patients and sputum culture conversion. Factors affecting time conversion throughout whole course rarely been investigated. This study was performed four cities Jiangsu province, China. MDR-TB were consecutively enrolled December 2011 March 2014. Rates calculated Cox proportional-hazards model performed. contributing to In all, 139 with...
Rationale: Patients with newly diagnosed tuberculosis often have inconsistent glycemic measurements during and after treatment. Distinct trajectories the diagnosis of are not well characterized, whether patients stress hyperglycemia poor treatment outcomes is known.Objectives: To identify distinct from point to posttreatment period assess relationship between outcomes.Methods: diagnosed, drug-susceptible at least three fasting plasma glucose tests third sixth month were identified included...
ObjectiveTo explore whether all individuals with diabetes are at an increased risk of tuberculosis or there high-risk groups patients.MethodsA population-based census was conducted in China, including 27 807 individuals. Risk factors for incident were investigated and participants included the study linked to Tuberculosis Management Information System. Cox proportional hazards models adjusting several variables constructed two steps. First, rate with/without compared without any...
This study aimed to investigate the association between drug exposure and adverse events (AEs) during standardized multidrug-resistant tuberculosis (MDR-TB) treatment, as well identify predictive thresholds.
Discordance between the QuantiFERON-TB Gold In-tube (QFT) and tuberculin skin test (TST) is not well understood. We aimed to identify factors that determine discordance TST QFT when compared either TST+QFT+ or TST-QFT- results in a medium tuberculosis (TB) burden setting.We conducted population-based study Eastern China administered TSTs QFTs participants. calculated kappa values while constructing multivariable logistic regression models evaluate predictors of discordance. analyzed...
Purpose Recurrent tuberculosis (TB) is defined by more than one TB episode per patient and caused re-infection with a new Mycobacterium (Mtb) strain or relapse the previous strain. Recurrence of important obstacle for End strategy in world elucidating triggers recurrence current control China. This study aimed to analyze sources recurrent molecular genotyping method. Method A population-based surveillance was undertaking on all culture-positive cases Jiangsu province, China from 2013 2019....