A5102973523- Crime Patterns and Interventions
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Cholesterol and Lipid Metabolism
- Influenza Virus Research Studies
- Telemedicine and Telehealth Implementation
- Respiratory viral infections research
- Crime, Illicit Activities, and Governance
- Sepsis Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Criminal Justice and Corrections Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Homelessness and Social Issues
- Pluripotent Stem Cells Research
- Aquaculture Nutrition and Growth
- Cytomegalovirus and herpesvirus research
- Emergency and Acute Care Studies
- COVID-19 epidemiological studies
Wuhan University
2000-2025
Fudan University
2016-2024
Chinese Academy of Fishery Sciences
2023-2024
Ocean University of China
2024
Huzhou Central Hospital
2023
Huzhou University
2023
ShenZhen People’s Hospital
2013-2021
Wuhan Children's Hospital
2021
Beijing Chaoyang Emergency Medical Center
2021
Second Affiliated Hospital of Zhengzhou University
2020
Growing evidence shows that neuropsychiatric disorders, such as depression, are linked with gut microbiome through the gut-brain axis. Cistanches Herba is well known for treatment of "kidney-yang" deficiency in traditional Chinese medicine (TCM), and has been used neurodegenerative diseases recent years. In this study, chronic unpredictable stress (CUS)-induced depression model was established to explore impact C. tubulosa extract (CTE) on behavioral tests, monoamine neurotransmitters...
Abstract Whole-genome sequencing (WGS) has shown tremendous potential in rapid diagnosis of drug-resistant tuberculosis (TB). In the current study, we performed WGS on Mycobacterium isolates obtained from Shanghai ( n = 137) and Russia 78). We aimed to characterise underlying high-frequency novel drug-resistance-conferring mutations, also create valuable combinations resistance mutations with high predictive sensitivity predict multidrug- extensively (MDR/XDR-TB) phenotype using a bootstrap...
The management of multidrug-resistant tuberculosis (MDR-TB) remains challenging. Treatment outcome is influenced by multiple factors; the specific roles diabetes and glycemic control remain uncertain. This study aims to assess impact on drug exposure, investigate association between exposure treatment outcomes, identify clinically significant thresholds predictive outcome, among patients with diabetes.
As urbanization accelerates, the importance of traffic prediction in optimizing intelligent management systems becomes increasingly evident. However, process accurate faces challenges such as complexity data, dynamic nature patterns, and inconsistency model performance across different conditions. To address these challenges, this paper proposes an innovative method based on ensemble models. Specifically, approach begins by creating a voting classifier that filters out highly models,...
Abstract Background Antimicrobial resistance (AMR) represents a critical global health threat, necessitating the identification of factors that contribute to its emergence and proliferation. We used "One Health" perspective evaluate association human veterinary antibiotic usage, environmental factors, socio-economic care with clinical AMR in China. Methods analyzed data from 31 provincial-level administrative divisions China, encompassing 20,762,383 bacterial isolates sourced China...
This study aimed to investigate the association between drug exposure and adverse events (AEs) during standardized multidrug-resistant tuberculosis (MDR-TB) treatment, as well identify predictive thresholds.
Abstract Background There is limited evidence supporting a relationship of ambient particulate matter (PM), especially PM 1 , with hospital admissions, costs, and length stay (LOS) due to cardiovascular disease (CVD). We used generalized additive model (GAM) estimate the associations these indicators CVD for each 10 μg/m 3 increase in level 2.5 attributable risk caused by on was determined using WHO air quality guidelines from 2005 2021. Results For 0-day lag time, there were significant...
This study characterized four cholesterol transport‐related genes, namely, lcat , acat1 acat2 and mttp in juvenile tiger puffer terms of tissue distribution (eye, heart, brain, skin, liver, spleen, muscle, intestine) nutritional regulation. Three feeding trials were conducted: (i) using diets with different levels (0.11%, 0.65%, 1.10%, 2.32%, 4.59% dry matter); (ii) lipid (8.05%, 12.02%, 16.36% (iii) a 1‐month starvation experiment sampling times (Days 1, 4, 9, 16, 31). The the most...
(1) Background: Along with an increasing risk caused by migrant workers returning to the urban areas for resumption of work and production growing epidemiological evidence possible transmission during incubation period, a study Coronavirus Disease 2019 (COVID-19) is warranted among key populations determine serum antibody against SARS-CoV-2 carrying status identify potential asymptomatic infection explore factors. (2) Method: This cross-sectional seroepidemiologic study. Three categories...
Lineage distribution of Mycobacterium tuberculosis (Mtb) isolates is strongly associated with geographically distinct human populations, and its transmission can be further impacted by the bacterial genome. However, epidemic success Mtb at an individual level was unknown in eastern China. Knowledge regarding emergence as well relevant factors may offer a new solution to curb spread disease. Thus, this study aims reveal evolution China.Of initial 1040 isolates, 997 were retained after...
As of October 5, 2020, China has reported 2,921 cases imported from overseas. Assessing the effectiveness China's current policies on abroad is very important for and other countries that are facing or will face overseas cases. In April, we used a susceptible-exposed-infectious-recovered metapopulation model to simulate epidemic in seven foreign countries, three Chinese key cities. Based outside China, estimated proportion people incubation period calculated risk indexes cities through...
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Abstract Background Although agonistic autoantibodies against type-1 angiotensin-II receptor (AT 1 -AA) are frequently detected in women with preeclampsia, the clinical significance of AT -AA association epithelial ovarian cancer (EOC) has not been identified. Methods In an attempt to clarify this issue, we measured serum titer from EOC patients (n = 89) and healthy normal subjects 55), correlated stage grade, demonstrated effects purified on migration cells angiogenesis chick embryo...
The present study explores situational social support of drug abusers during compulsory rehabilitation and provides a preliminary estimation relationship between relapse. Links relapse are examined in accepting coercive detoxification treatment, self-reported the following 6 months ( N = 535). External internal with abstinence-specific inclusive investigated. With certain demographic variables risk-related controlled, greater special type external (as measured by number children) predicts...
Although cycloserine is a recommended drug for the treatment of multidrug-resistant tuberculosis (MDR-TB) according to World Health Organization (WHO), few studies have reported on pharmacokinetics (PK) and/or pharmacodynamics (PD) data in patients with standardized MDR-TB treatment. This study aimed estimate population PK parameters and identify clinically relevant PK/PD thresholds, as well evaluate current dosage. Data from large cohort full curves was used develop model. model exposure...
Abstract Background Type 2 diabetes mellitus (T2DM) is a commonly observed complication associated with obesity. The effect of fibroblast growth factor 19 (FGF19), promising therapeutic agent for metabolic disorders, on pancreatic β cells in obesity-associated T2DM remains poorly understood. Methods Human were cultured high glucose (HG) and palmitic acid (PA), followed by treatment FGF19. cell proliferation, apoptosis, insulin secretion evaluated CCK-8, qRT-PCR, ELISA, flow cytometry,...
As a result of decades rapid development, aquaculture has become the largest contributor to human seafood consumption [...]
On January 30, 2024, China announced the first human case of H10N5 influenza infection. Prior to this, cases H10N7 and H10N8 had been reported. It is now appropriate re-examine evolution future epidemiological trends H10 N5 subtypes avian viruses (AIVs). In this study, we analyzed reassortment characteristics human-derived AIV (A/Zhejiang/ZJU01/2023), as well evolutionary dynamics wild bird-derived AIVs over past decade. Our findings indicate that exhibited low pathogenicity....
Diabetes mellitus is a chronic metabolic disorder with high morbidity and mortality, but its pathogenesis not fully understood. An increasing amount of evidence indicates that an immune mechanism plays important role in the diabetes. We demonstrated previously long-term presence autoantibodies against second extracellular loop β1-adrenoceptor (β1-AA) could change ratio peripheral CD4+T/CD8+T rats, which was accompanied by lymphocytes infiltration rat heart, liver, kidneys. To investigate...
Cholesterol has been used as additive in fish feeds due to the reduced use of meal and oil. In order evaluate effects dietary cholesterol supplementation (D-CHO-S) on physiology, a liver transcriptome analysis was performed following feeding experiment turbot tiger puffer with different levels cholesterol. The control diet contained 30% (0% oil) without supplementation, while treatment supplemented 1.0% (CHO-1.0). A total 722 581 differentially expressed genes (DEG) between groups were...
We will investigate the effects of exenatide on vascular endothelial injury and nitrooxidative stress in hyperglycemia both vivo vitro explore role endothelium-protective action exenatide. Healthy male Wistar rats were randomly divided into 4 groups: control, diabetes mellitus (DM) model, low dose treatment, high treatment. In study showed that, compared with control group, DM exhibited a lowered endothelium-dependent relaxation damaged structural integrity thoracic aortas, there was...