A5101489693- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Wood and Agarwood Research
- Plant biochemistry and biosynthesis
- Tea Polyphenols and Effects
- Chromatography in Natural Products
- Phytochemical Studies and Bioactivities
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects of Natural Compounds
- Plant Parasitism and Resistance
- Phytochemistry and Bioactive Compounds
- Microbial Metabolism and Applications
- GABA and Rice Research
- Ginseng Biological Effects and Applications
- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
- Bone Metabolism and Diseases
- Zebrafish Biomedical Research Applications
- Phytochemical compounds biological activities
- Medicinal Plants and Bioactive Compounds
- Herbal Medicine Research Studies
- Cardiac Fibrosis and Remodeling
- Curcumin's Biomedical Applications
China Pharmaceutical University
2023-2025
Peking University
2016-2025
Beijing University of Chinese Medicine
2016-2025
Changchun University of Chinese Medicine
2024
State Council of the People's Republic of China
2017
Shenyang Pharmaceutical University
2006
Echinacoside (ECH), one of the most representative phenylethanoid glycosides (PhGs), has considerable neuroprotective effects and is an effective ingredient in numerous commercial drugs. Here, we elucidate complete ECH biosynthetic pathway medicinal plant Cistanche tubulosa. In total, 14 related genes are cloned functionally characterized. Two upstream pathways for tyrosol biosynthesis from L-tyrosine identified: includes separate decarboxylation, deamination reduction steps; other uses...
Abstract 2-(2-Phenylethyl)chromones (PECs) are the principal constituents contributing to distinctive fragrance of agarwood. How PECs biosynthesized is currently unknown. In this work, we describe a diarylpentanoid-producing polyketide synthase (PECPS) identified from Aquilaria sinensis . Through biotransformation experiments using fluorine-labeled substrate, transient expression PECPS in Nicotiana benthamiana , and knockdown A. calli, demonstrate that C 6 –C 5 scaffold diarylpentanoid...
Growing evidence shows that neuropsychiatric disorders, such as depression, are linked with gut microbiome through the gut-brain axis. Cistanches Herba is well known for treatment of "kidney-yang" deficiency in traditional Chinese medicine (TCM), and has been used neurodegenerative diseases recent years. In this study, chronic unpredictable stress (CUS)-induced depression model was established to explore impact C. tubulosa extract (CTE) on behavioral tests, monoamine neurotransmitters...
Two new phenolic compounds, epicaesalpin J and 7,10,11-trihydroxydracaenone, were isolated from the heartwood of Caesalpinia sappan L. Their structures identified by spectroscopic analysis methods, such as 1D 2D NMR, along with high resolution mass spectral data. The NO inhibition activities two compounds six known tested.
The present study aimed to evaluate the therapeutic effect and explore underlying mechanisms of Longxue Tongluo Capsule (LTC) on ischemic stroke rats.Twenty-six rats were randomly divided into four groups, including sham group, + LTC MCAO group. Ischemic simulated by middle cerebral artery occlusion (MCAO), treatment group orally administrated with 300 mg/kg once daily for seven consecutive days. therapy was validated in terms neurobehavioral abnormality evaluation, infarct area,...
Echinacoside (ECH) is a major bioactive phenyethanoids in medicinal herba Cistanche and has been reported to have antiinflammatory activity beneficial effect on wound healing many experimental studies. This study was test the efficacy of ECH‐enriched extract tubulosa treatment dextran sulphate sodium (DSS)‐induced colitis, preclinical model ulcerative colitis. Oral administration ECH significantly suppresses development acute indicated by lowering disease index ( p < 0.0001, n = 8)...
Frequent alteration of upstream proto-oncogenes and tumor suppressor genes activates mechanistic target rapamycin (mTOR) causes cancer. However, the downstream effectors mTOR remain largely elusive. Here we report that brain-expressed X-linked 2 (BEX2) is a novel effector mTOR. Elevated BEX2 in Tsc2(-/-) mouse embryonic fibroblasts, Pten(-/-) Tsc2-deficient rat uterine leiomyoma cells, brains neuronal specific Tsc1 knock-out mice were abolished by inhibitor rapamycin. Furthermore, was also...
A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones 1,3-diketones via head-to-head condensation two completely different substrates. The broad range substrate tolerance HsPKS3 facilitates accessing structurally diverse 1,3-diketones.
The rhizome of Corydalis decumbens is a traditional Chinese medicine commonly utilized in the clinical treatment acute ischemic stroke. Numerous phytochemical and biological investigations have demonstrated that protoberberine alkaloids from C. exhibit diverse pharmaceutical activities against various diseases. Sinometumine E (SE), alkaloid isolated for first time, characterized by complex 6/6/6/6/6/6 hexacyclic skeleton. In current study, we investigated protective effects SE on endothelial...
Echinacoside (ECH) is one of the representative phenylethanoid glycosides. It widely present in plants and exhibits various bioactivities. However, extremely low oral bioavailability ECH rats implies that may go through multiple hydrolysis steps gastrointestinal tract prior to its absorption into blood. Therefore, metabolites are more likely be bioactive components. This study established an approach combining ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry...