A5100350613- Alzheimer's disease research and treatments
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Anesthesia and Pain Management
- Kruppel-like factors research
- Alkaline Phosphatase Research Studies
- Genomics, phytochemicals, and oxidative stress
- Fibroblast Growth Factor Research
- Enhanced Recovery After Surgery
- Advanced Glycation End Products research
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Plant biochemistry and biosynthesis
- Ferroptosis and cancer prognosis
- Intraocular Surgery and Lenses
- Pregnancy and preeclampsia studies
- Neurological Disease Mechanisms and Treatments
- Microbial Natural Products and Biosynthesis
- Diet and metabolism studies
- Nausea and vomiting management
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Women's Hospital, School of Medicine, Zhejiang University
2021-2025
Zhejiang University of Technology
2025
Kunming Third People's Hospital
2024
Second Affiliated Hospital of Guangzhou Medical University
2022-2024
Guangzhou Medical University
2022-2024
China Medical University
2012-2024
Peking Union Medical College Hospital
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Berberine is one of the main alkaloids Rhizoma coptidis which has been used as a folk medicine to treat diabetes mellitus for more than 1400 years in China. To investigate chronic effect berberine on diabetic hyperlipidemic rats, fasted rats were intraperitoneally injected 35 mg/kg streptozotocin. Diabetic admitted after 2 weeks and given high-carbohydrate/high-fat diet induce hyperlipidemia. The divided into 7 groups at end week 16: normal received no drug, 5 treatment administered with...
Ferroptosis is a recently recognized form of regulated cell death, characterized by iron-dependent accumulation lipid peroxidation. Ample evidence has depicted that ferroptosis plays an essential role in the cause or consequence human diseases, including cancer, neurodegenerative disease and acute kidney injury. However, exact underlying mechanism fibrotic remain unknown. Acyl-CoA synthetase long-chain family member 4 (ACSL4) been demonstrated as component execution shaping composition. In...
Abstract Immune checkpoint blockades have been prized in circumventing and ablating the impediments posed by immunosuppressive receptors, reaching an exciting juncture to be innovator anticancer therapy beyond traditional therapeutics. Thus far, approved immune principally targeted PD-1/PD-L1 CTLA-4 with success a plethora of tumors yet are still trapped dilemmas limited response rates adverse effects. Hence, unveiling new immunotherapeutic targets has aroused immense scientific interest...
Background: Physical weakness and cardiovascular risk increase significantly with age, but the underlying biological mechanisms remain largely unknown. This study aims to reveal causal effect of circulating metabolites on frailty, sarcopenia vascular aging related traits diseases through a two-sample Mendelian Randomization (MR) analysis. Methods: Exposures were 486 analyzed in genome-wide association (GWAS), while outcomes included sarcopenia, arterial stiffness, atherosclerosis, peripheral...
Methyltransferase-like 3 (METTL3)-modulated N6-methyladenosine (m6A) was recently identified as an important epigenetic regulation type during RNA processing and contributes to multiple pathological processes. Neuropathic pain (NP) is induced by a lesion of the somatosensory nervous system, detailed pathways which METTL3/m6A regulated modulate gene dysregulation enable NP have remained unclear. Therefore, this study investigated function METTL3-mediated m6A methylation on miRNA maturation,...
Aging of the vasculature, which is integral to functioning literally all human organs, serves as a fundamental physiological basis for age-related alterations well shared etiological mechanism various chronic diseases prevalent in elderly population. China, home world's largest aging population, faces an escalating challenge addressing prevention and management these conditions. To meet this challenge, Biomarker Consortium China has developed expert consensus on biomarkers vascular (VA) by...
A chronic high fat Western diet (WD) promotes a variety of morbidity factors although experimental evidence for short-term WD mediating brain dysfunction remains to be elucidated. The amyloid precursor protein and presenilin-1 (APP x PS1) knock-in mouse model has been demonstrated recapitulate some key features Alzheimer's disease pathology, including amyloid-beta (Abeta) pathogenesis. In this study, we placed 1-month-old APP PS1 mice non-transgenic littermates on 4 weeks. resulted in...
As a part of aging there are known to be numerous alterations which occur in multiple tissues the body, and focus this study was determine extent oxidative stress hypoxia during adipose tissue aging. In our studies we demonstrate for first time that is associated with both (38% reduction oxygen levels, Po(2) 21.7 mmHg) increases reactive species visceral fat depots male C57Bl/6 mice. Interestingly, were observed have significantly less change expression genes involved redox regulation...
Background: The fact that serum thyrotropin (TSH) levels increase with age may influence the diagnosis of thyroid diseases in older adults. This study aimed to establish an age-specific TSH reference range, examine prevalence adults ≥65 years, and analyze risk factors. Methods: A cross-sectional adult populations 10 cities China was conducted from 2010 2011. total 15,008 subjects were randomly selected completed present study. Urinary iodine concentration, TSH, peroxidase antibody (TPOAb),...
Abstract Following a chronic insult, renal tubular epithelial cells (TECs) contribute to the development of kidney fibrosis through dysregulated lipid metabolism that lead accumulation and lipotoxicity. Intracellular is tightly controlled by fatty acids (FAs) uptake, oxidation, lipogenesis, lipolysis. Although it widely accepted impaired oxidation (FAO) play crucial role in progression, other metabolic pathways, especially FAs has not been investigated fibrotic kidney. In this study, we aim...