A5047526193- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
- Digital Media and Visual Art
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic function and diabetes
- Natural Antidiabetic Agents Studies
- Bioactive natural compounds
- Neurotransmitter Receptor Influence on Behavior
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Biomedical Ethics and Regulation
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
- Prenatal Substance Exposure Effects
- Diet, Metabolism, and Disease
- Pain Mechanisms and Treatments
- Ethics in Clinical Research
- Ethics in medical practice
- Nerve injury and regeneration
- Diabetic Foot Ulcer Assessment and Management
- Traditional and Medicinal Uses of Annonaceae
- Memory and Neural Mechanisms
- Schizophrenia research and treatment
- Alzheimer's disease research and treatments
Army Medical University
2015-2025
Chongqing Medical University
2017-2024
Second Affiliated Hospital of Chongqing Medical University
2017-2024
Dalian Medical University
2017-2024
Chongqing Vocational Institute of Engineering
2023
Xinqiao Hospital
2009-2020
Institute of Art
2011
Nanjing University of the Arts
2006-2011
University Hospital Frankfurt
2007
Goethe University Frankfurt
2007
Abstract Oxidative stress in diabetes coexists with a reduction the antioxidant status, which can further increase deleterious effects of free radicals. Trigonelline is major component Mirabilis jalapa L., has been used to treat China. The present study was designed evaluate beneficial trigonelline against hyperglycemia, hyperlipidemia, β cell damage and pancreas diabetic rats. Diabetic rats were induced by intraperitoneal injection 35 mg/kg streptozotocin high‐carbohydrate/high‐fat diet....
<title>Abstract</title> <bold>Aims</bold>: Alterations in iron homeostasis are associated with several neurodegenerative diseases. Cognitive dysfunction has become an important concomitant symptom people type 2 diabetes mellitus. Therefore, we investigated the role of neuritin ameliorating cognitive resulting from ferroptosis diabetic neurons using a model overexpression GABAergic. <bold>Methods</bold>: The constructed transgenic mice were used to observe memory function changes Morris water...
Gestational diabetes mellitus (GDM) is a glucose metabolism abnormality that first emerges during pregnancy and may negatively affect the behavioral neurodevelopmental outcomes of offspring. Quetiapine (QUE) has been shown to promote differentiation oligodendrocyte precursor cells (OPCs) protect oligodendrocytes myelination. To explore effects QUE on improving expression conditioned place preference (CPP) myelination in infralimbic cortex (IL) medial prefrontal alcohol-exposed GDM offspring...
The mechanisms leading to diabetic peripheral neuropathy are complex and there is no effective drug treat it. As an active component of several traditional Chinese medicines, trigonelline has beneficial effects on diabetes with hyperlipidemia. protective the mechanism were evaluated in streptozotocin- high-carbohydrate/high-fat diet-induced rats. Rats divided into four groups at end week 2: control, diabetes, + (40 mg/kg), sitagliptin (4 mg/kg). After 48-week treatment, technologies nerve...
Abstract Omentin‐1 is an adipokine expressed by the adipose tissue and reduced in obesity. This study was designed to calculate protective efficiency mechanism of omentin‐1 against inflammation obese mice. A transgenic mouse model with protein overexpression established crossing mice Fabp4‐Cre Obesity induced feeding them a high‐fat diet for 10 weeks. Fabp4‐Cre‐mediated significantly increased serum level, anti‐inflammatory factor levels, expression M2‐specific mRNAs; inhibited body weight...
Disorders of the blood-brain barrier (BBB) arising from diabetes mellitus are closely related to diabetic encephalopathy. Previous research has suggested that neuron-glia antigen 2 (NG2)-glia plays a key role in maintaining integrity BBB. However, mechanism by which NG2-glia regulates BBB remains unclear.
Intracerebroventricular injection and overexpression of Neuropeptide Y (NPY) in the paraventricular nucleus (PVN) has been shown to induce obesity glucose metabolism disorder rodents; however, underlying mechanisms are still unclear. The aim this study was investigate mechanism contributing metabolic disturbance induced by NPY. Recombinant lentiviral NPY vectors were injected into PVN rats fed a high fat (HFD) or low-fat diet. 8 weeks later, vivo intravenous tolerance tests...
As an active component from traditional Chinese medicine, trigonelline has a protective effect on diabetes. This study evaluated the effects of diabetic mice during pregnancy.Diabetes was induced in female by intraperitoneal injection for continuous 5-day 40 mg/kg/day streptozotocin. Female were divided into 4 groups after they allowed to mate with normal male mice: nondiabetic, nondiabetic treated (70 mg/kg) 18 days, diabetic, and mg/kg).Diabetic pregnant had significantly higher levels...