Ferroptosis is a recently recognized form of regulated cell death, characterized by iron-dependent accumulation lipid peroxidation. Ample evidence has depicted that ferroptosis plays an essential role in the cause or consequence human diseases, including cancer, neurodegenerative disease and acute kidney injury. However, exact underlying mechanism fibrotic remain unknown. Acyl-CoA synthetase long-chain family member 4 (ACSL4) been demonstrated as component execution shaping composition. In...

Ferroptosis is a non-apoptotic form of regulated cell death that involves an imbalance in the homeostasis two elements: iron and lipid hydroperoxides. The accumulation hydroperoxide serves as key trigger for initiating ferroptosis. Recent studies have identified ferroptosis critical pathophysiology contributing to kidney disease progression. However, specific mechanisms underlying role chronic (CKD) not been elucidated. Tubular epithelial cells (TECs) was evaluated unilateral ureteral...

Some professional associations advocate bedsharing to facilitate breastfeeding, while others recommend against it reduce the risk of sudden infant death syndrome and suffocation deaths. A better understanding quantitative influence on breastfeeding duration is needed guide policy.To quantify duration.Longitudinal data were from Infant Feeding Practices Study II, which enrolled mothers pregnant followed them through first year life. Questionnaires sent at ages 1 7, 9, 10, 12 months, 1846...

To evaluate a novel designed degradable ureteral stent.A total of 24 male Beagles, each with bilateral stents implanted (a biodegradable 4.5-Fr stent and standard 4-Fr biostable stent) were divided into four groups. Intravenous pyelography, B-mode ultrasonography, blood urine tests carried out before the procedure (0 weeks), at 1-, 2-, 3- 4-week intervals. Meanwhile, mechanical characteristics tested, scanning electron microscopy images braided obtained different time-points postoperatively....

Extensive global research has been conducted to explore the neural mechanisms involved in acupuncture treatment for central nervous system (CNS) disorders. However, there is a lack of bibliometric analysis specifically focusing on functional magnetic resonance imaging (fMRI) studies examining effects CNS diseases. This study aims fill this gap by offering theoretical framework current clinical application and future directions. It presents comprehensive overview state, hotspots, trends fMRI...

Abstract Background Infant formula is marketed by health professionals and directly to consumers. Formula marketing has been shown reduce breastfeeding, but the relation with switching formulas not studied. Willingness switch can enable families spend less on formula. Methods Data are from Feeding Practices Study II , a U nited S tates national longitudinal study. Mothers were asked about media exposure information during pregnancy, receiving samples or coupons at hospital discharge, reasons...

Background/Objective: Many studies have focused on the effects of previous breastfeeding experience (PBE) subsequent breastfeeding, but few explored their specific relationships. To explain relationship between PBE and behavior based a follow-up study. Materials Methods: After delivery, 394 participants who had no completed demographic questionnaire, knowledge self-efficacy short-form scale (BSES-SF), Iowa infant feeding attitudes (IIFAS). Multiparas with also maternal evaluation (MBFES) in...

ATP-binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) are involved in the HDL metabolism play a key role reverse cholesterol transport. The study aim was mainly to examine possible association of ABCA1 CETP polymorphisms with overweight/obesity South-West Chinese population.Three hundred thirty-eight Han (206 overweight/obese 132 normal control subjects) Chengdu area were studied using PCR-RFLP analysis. genotype allele frequencies R219K, Taq IB -629C > A...

Abstract Physical inactivity is known to cause many health problems globally each year. However, evidence regarding the interaction between excessive physical activity (PA) and blood pressure in young middle-aged populations limited. A multistage, stratified, random cluster sampling design was adopted recruit representative samples. Participants were asked complete a questionnaire undergo examinations. Associations prehypertension, hypertension PA durations examined by multivariable logistic...

Paragangliomas (PGLs) are rare neuroendocrine tumors which overproduce catecholamines (CAs). They extra-adrenal, catecholamine-secreting occurring outside the adrenal glands. Gastric PGLs originating from extra-adrenal paraganglia exceptionally rare, and their presentation in geriatric patients further adds to complexity of diagnosis management. A 72-year-old male patient presented with enduring left upper abdominal pain anemia persisting for over a year, hypertension six months. Physical...

Background Apolipoprotein E (apo ) polymorphism has been reported to influence some lipid profile abnormalities in ethnic groups. This study was conducted mainly examine the possible association of apo with overweight/obesity a South West Chinese population. Methods Four hundred and fifty‐four H an C hinese (282 overweight/obese 172 normal weight control subjects) hengdu area were studied using polymerase chain reaction‐restriction fragment length ( PCR ‐ RFLP analysis. Results The genotype...

The aims of this study were to investigate the association between different obesity indices and left ventricular mass (LVM) develop interventions for obese hypertensive patients delay progression hypertrophy (LVH). visceral adiposity index (VAI) LVM was explored using multiple regression analysis in all subjects (<i>n</i> = 1,035), subgroups aged < 65 713) ≥65 years 322), perimenopausal women 319). VAI only associated with LVH (OR 1.134; 95% CI 1.025–1.254,...

The extent to which health and survival inequality between indigenous nonindigenous older Taiwanese is associated with diet uncertain.Participants from the Elderly Nutrition Health Survey in Taiwan (1999-2000) formed this cohort. Dietary information was collected by 24-hr recall simplified food frequency questionnaire. quality assessed dietary diversity score (DDS, 0-6). Annual medical service utilization expenditure were derived National Insurance claims until 2006. Survivorship ascertained...

The relationship between prior breastfeeding experience and the duration of exclusive is significant interest, but few studies have explored mechanisms underlying this relationship. purpose study to address two hypotheses: (a) that attitude self-efficacy mediate previous breastfeeding; (b) serial mediation functions in relationship.The data collection process was divided into stages. original stage included 394 women hospitalized after delivery who completed socio-demographic questionnaires...