A5112552609- Maternal Mental Health During Pregnancy and Postpartum
- Tryptophan and brain disorders
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Pain Mechanisms and Treatments
- Intensive Care Unit Cognitive Disorders
- Treatment of Major Depression
- Stress Responses and Cortisol
- Pain Management and Opioid Use
- Neuroinflammation and Neurodegeneration Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Antibiotics Pharmacokinetics and Efficacy
- Neuroendocrine regulation and behavior
- Drug Transport and Resistance Mechanisms
- Airway Management and Intubation Techniques
- Family Support in Illness
- Inflammatory mediators and NSAID effects
- Inflammasome and immune disorders
- Epilepsy research and treatment
- Adolescent and Pediatric Healthcare
- Maternal and Perinatal Health Interventions
- Eicosanoids and Hypertension Pharmacology
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
Air Force Medical University
2021-2025
Tang Du Hospital
2023-2025
Central South University
2015-2024
Third Xiangya Hospital
2014-2024
PharmacoGenetics (China)
2009-2019
Xiangya Hospital Central South University
2014-2017
Purpose: To assess the pharmacokinetics and safety of pure S-ketamine (esketamine) in Chinese patients undergoing painless gastroscopy evaluate potential advantage esketamine clinical treatment compared with racemate ketamine hydrochloride injection. Patients methods: A randomized, open-label, parallel-controlled, Phase I study was performed 32 gastroscopy. received a single dose (0.5 mg/kg) or racemic (1 mg/kg, esketamine:R-ketamine=1:1), injected 10 s. Blood samples were collected for...
Background. We aimed to investigate the distributive characteristics of SLC22A1 rs594709 and SLC47A1 rs2289669 polymorphisms their influence on metformin efficacy in Chinese T2DM patients. Methods. The distributions were determined 267 patients 182 healthy subjects. Subsequently, 53 newly diagnosed who received monotherapy recruited evaluate efficacy. Results. No significant difference was found between subjects allele frequencies genotype frequencies. After treatment, GG showed a higher...
Importance Postpartum depression (PPD) is emerging as a major public health problem worldwide. Although the particular period and context in which PPD occurs provides an opportunity for preventive interventions, there still lack of pharmacologic prevention strategies PPD. Objective To assess efficacy safety dexmedetomidine among women with prenatal undergoing cesarean delivery. Design, Setting, Participants This randomized clinical trial enrolled 338 who screened positive at 2 hospitals...
MicroRNA-125a-5p modulates human cervical carcinoma proliferation and migration by targeting ABL2 Xian Qin,1 Yajun Wan,1 Saiying Wang,2 Min Xue1 1Department of Obstetrics Gynecology, 2Department Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, People’s Republic China Background: In this study, we intended to understand the regulatory mechanisms microRNA-125a-5p (miR-125a-5p) in carcinoma.Methods: The gene expressions miR-125a-5p seven cell lines 12 samples...
Abstract JOURNAL/nrgr/04.03/01300535-202403000-00040/inline-graphic1/v/2023-09-27T141015Z/r/image-tiff β-Sitosterol is a type of phytosterol that occurs naturally in plants. Previous studies have shown it has anti-oxidant, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, and anti-tumor effects, but unknown whether β-sitosterol treatment reduces the effects ischemic stroke. Here we found that, mouse model stroke induced by middle cerebral artery occlusion, reduced volume infarction...
Objectives Few studies have investigated the prophylactic efficacy of dexmedetomidine (DEX) in postpartum depressive symptoms (PDS). A randomized double‐blind placebo‐controlled trial was conducted to investigate whether administration DEX, immediately after delivery and for patient‐controlled intravenous analgesia (PCIA), can attenuate PDS. Methods total 600 parturients scheduled elective cesarean under spinal anesthesia were randomly allocated into control group (infusion with 0.9% normal...
Background: With the development of fiberoptic bronchoscopy in diagnosis and treatment various pulmonary diseases, anesthesia/sedation requirements are becoming more demanding, posing great challenges for patient safety while ensuring a smooth examination/surgery process. Remimazolam, brand-new ultra-short-acting anesthetic, may compensate shortcomings current anesthetic/sedation strategies bronchoscopy. Methods: This study was prospective, multicenter, randomized, double-blind, parallel...
Globally, more than 300,000 fatalities occur from burns annually, and burn-wound healing continues to present significant challenges owing the wound's propensity for infections, heavy bleeding, poor angiogenesis, persistent inflammatory responses. The immunomodulation of macrophage polarization toward M2 phenotype facilitates burn wounds by controlling tissue microenvironment expediting transition phase proliferation. Here, a polydopamine-mediated graphene oxide (GA), tannic acid (TA),...
This study explored the role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on efficacy duration action rocuronium in Chinese patients. Two hundred seven unrelated patients scheduled for elective surgery were recruited, 200 completed study. Their genotypes determined. Demographic clinical non-genetic data also collected. The variants did not affect onset time rocuronium. Clinical recovery prolonged with ABCB1 rs1128503TT SLCO1B1 rs2306283 AG GG genotypes. We demonstrate that could...
Chronic pain is a common condition that causes negative emotions as the disease progresses. The anterior cingulate cortex (ACC) key region in integration of nociceptive perception and emotional response chronic pain. Linderane (LDR) an active ingredient from Linderae radix, traditional Chinese medicine with anti-inflammatory, analgesic, antibacterial properties. In this study, analgesic antianxiety effects LDR were evaluated using complete Freund's adjuvant (CFA)-induced inflammatory model...
The aims of this study were to investigate the effect quercetin on CYP3A activity in vivo. An open, randomized, 2‐period crossover experiment was performed 18 healthy male volunteers. Genotyped data available from a total 165 participants. allelic frequency 52.5%. Every volunteer ingested orally 500 mg or placebo once day for 13 consecutive days. On 14, single 7.5‐mg midazolam tablet administrated orally. plasma concentrations and 1‐OH‐midazolam determined over 24 hours. results showed that...
Background: The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for subsequent children. Methods: Part 1: double-blind, placebo-controlled, single ascending dose was performed on 48 subjects. For 20-/40-μg groups, every 6/2 subjects received either Dex/placebo or injection two periods. In total, 12/4 each 100 μg spray. 2: randomized, placebo-controlled...