A5074181753- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Diagnosis and Treatment of Venous Diseases
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Airway Management and Intubation Techniques
- Lipid Membrane Structure and Behavior
- Venous Thromboembolism Diagnosis and Management
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Respiratory viral infections research
- Advanced Drug Delivery Systems
- Occupational and environmental lung diseases
- Antimicrobial Peptides and Activities
- Biomarkers in Disease Mechanisms
- Cytokine Signaling Pathways and Interactions
- Intensive Care Unit Cognitive Disorders
- Gene expression and cancer classification
- Gastrointestinal motility and disorders
- Cancer Cells and Metastasis
- S100 Proteins and Annexins
- Meta-analysis and systematic reviews
Yichang Central People's Hospital
2010-2022
China Three Gorges University
2010-2022
Fujian University of Traditional Chinese Medicine
2019
State Key Laboratory of Respiratory Disease
2018
Second Military Medical University
2013-2017
Beijing Chao-Yang Hospital
2009
Huazhong University of Science and Technology
2006-2007
Tongji Hospital
2006
Abstract The use of corticosteroids has been controversial in viral pneumonia. In most cases, application methylprednisolone severe and critical pneumonia patients can quickly alleviate the symptoms dyspnea prevent disease progression. However, some scholars have confirmed that delayed body's clearance virus. our retrospective non‐randomized study, 34 under 50 years old diagnosed with coronavirus 2019 (COVID‐19) were included. According to given treatment (n = 18) or not 16), they separated...
Background: With the development of fiberoptic bronchoscopy in diagnosis and treatment various pulmonary diseases, anesthesia/sedation requirements are becoming more demanding, posing great challenges for patient safety while ensuring a smooth examination/surgery process. Remimazolam, brand-new ultra-short-acting anesthetic, may compensate shortcomings current anesthetic/sedation strategies bronchoscopy. Methods: This study was prospective, multicenter, randomized, double-blind, parallel...
miR-19 is a critical carcinogenic miRNA that participates in important biological processes of human malignancies. CBX7 plays key role lung cancer development and progression. In the present study, for first time, we investigated correlation between non-small-cell (NSCLC).miR-19 expression NSCLC tissues cell lines was detected using quantitative reverse transcriptase PCR (qRT-PCR). Luciferase reporter assay, qRT-PCR, Western blot, immunohistochemical assay were conducted to identify target...
As a member of the S100 protein family, S100A11 expression is often upregulated in human cancer tissues. Numerous studies have demonstrated that plays an important role progression cancer. However, function ovarian remains elusive. In present study, levels were found to be significantly increased cells. Subsequently, HO8910 cells was knocked down using short hairpin (sh)RNA order investigate biological effects on disease. The results knockdown by shRNA inhibited proliferation,...
Current photodynamic therapy faces two major challenges, which are the limited tissue penetration of excitation light and poor tumor selectivity photosensitizer. To address these issues, in present work, a photosensitizer protoporphyrin IX was delivered by aptamer-coated upconversion nanoparticles. The aptamer, namely, AS1411, could fold to G-quadruplex structures with bi-functions loading targeting cancerous cells. nanoparticle nanospheres exhibited good biocompatibility, high nuclease...
Circular RNAs (circRNAs) are non-coding molecules consisting of a covalently closed continuous loop which have no 5'-3' polarity and contain polyA tail. Accumulating evidence demonstrates that circRNAs involved in the initiation progression human malignancies. In this study, we explored expression profile regulatory role circ-baculoviral IAP repeat-containing 6 (circ-BIRC6), circular RNA, malignant behaviors non-small cell lung cancer (NSCLC). Expression levels circ-BIRC6 miR-4491 were...
Background: This study aimed to explore the efficacy and safety of drug-eluting beads bronchial arterial chemoembolization (DEB-BACE) compared with conventional (cBACE) in lung cancer patients hemoptysis. Materials & methods: Thirty-six hemoptysis treated by DEB-BACE or cBACE were retrospectively analyzed. Results: Technical success BACE clinical treatment no different between (both p > 0.050), whereas achieved increased total response (p = 0.021), objective rate 0.035) prolonged...
<h3>Objectives:</h3> To investigate the efficacy and safety of initial thrombolysis by recombinant tissue-type plasminogen activator (rt-PA) in compared with anticoagulant therapy patients acute intermediate-risk pulmonary embolism (PE). <h3>Methods:</h3> Sixty-six PE were randomly assigned to receive rt-PA or LMWH between June 2014 2017 our department. We obtained information regarding difference right ventricle/left ventricle (RV/LV) ratio, artery systolic pressure (PASP), clinical...
The aim of this study was to evaluate the effectiveness and safety diagnostic flexi-rigid thoracoscopy in differentiating exudative pleural effusion unknown etiology.A total 215 patients with undiagnosed were consecutively recruited between January 2011 February 2013. Thoracoscopy carried out under local anesthesia, multisite biopsies performed using a thoracoscope. tolerance patients, surgical complications postoperative pathological diagnosis rate used procedures.All Karnofsky performance...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel with higher transmissibility compared SARS (SARS-CoV) and Middle East distress coronavirus. Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 an unprecedented global crisis that has not been experienced, which still disrupting health systems, economies, societies around the world rapid spread. Bronchoscopy plays important role in diagnosis therapy of pulmonary diseases, especially patients severe infection,...
The objective of the present study was to develop a liposomal drug delivery system based on combretastatin A4 (CA4) prodrugs modified with varying alkyl chains and investigate in vitro conversion from prodrug vivo antitumor effect.The CA4 synthesized stearyl chloride (18-carbon chain), palmitoyl (16-carbon myristoyl (14-carbon decanoyl (10-carbon hexanoyl (6-carbon chain) at 3'-position CA4. Subsequently, it encapsulated liposomes through thin-film evaporation method. Furthermore,...
The aim of the present study was to identify differentially expressed molecular functions (DEMFs) for breast cancer using Gibbs sampling approach. Molecular (MFs) were obtained on basis Bayesian Approach Geneset Selection package. Subsequently, MFs converted into Markov chains (MCs) prior calculating their probabilities, utilizing MC Monte Carlo algorithm. DEMFs identified with probabilities ≥0.8 and gene compositions studied. Finally, a co-expression network constructed via empirical Bayes...
Asthma is a chronic disease characterized by reversible airway obstruction, hyperresponsiveness, and inflammation of airways. Th2 cells, one sort CD4+ T lymphocytes, are currently considered to play an important role in the asthma. Meanwhile, number laboratories have clearly established importance Th2-derived cytokine interleukin-4 (IL-4) mediating inflammatory response. Anti-IL-4 therapy might be beneficial treatment Gene represents novel approach for Compared with other virus vectors,...