A5101647702- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Genomics, phytochemicals, and oxidative stress
- Colorectal Cancer Screening and Detection
- RNA regulation and disease
- Colorectal and Anal Carcinomas
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- Fibroblast Growth Factor Research
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- interferon and immune responses
- Colorectal Cancer Treatments and Studies
- Acute Myeloid Leukemia Research
- Hedgehog Signaling Pathway Studies
- Traditional Chinese Medicine Analysis
Liaoning Cancer Hospital & Institute
2017-2025
China Medical University
2014-2024
Rutgers, The State University of New Jersey
2024
Rutgers Sexual and Reproductive Health and Rights
2024
Shanghai Electric (China)
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2023
Liaoning Provincial People's Hospital
2023
First Affiliated Hospital of Xi'an Jiaotong University
2020-2023
Tianjin University of Science and Technology
2013-2022
Fuzhou Maternity and Child Health Care Hospital
2021
Non-coding RNAs (ncRNAs) have been shown to regulate gene expression involved in tumor progression of multiple malignancies. Our previous studies indicated that large suppressor kinase 1 (LATS1), a core part Hippo signaling pathway, functions as gastric cancer (GC). But, the underlying molecular mechanisms by which ncRNAs modulate LATS1 GC remain undetermined. The correlation and has-miR-424-5p (miR-424) with clinicopathological characteristics prognosis patients was analyzed TCGA...
Circular RNAs (circRNAs) are a new type of non-coding and their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that circRNAs play an important role development certain types pathological responses, acting as microRNA (miRNA) sponges to regulate gene expression. CircNet was used screen potential validated circYAP1 expression levels 17 GC tissues by quantitative real-time PCR (qRT-PCR) another 80 paired FISH. CircYAP1 overexpression knockdown experiments were...
Primary or acquired resistance to cetuximab often occurs during targeted therapy in metastatic colorectal cancer (mCRC) patients. In many cancers, the key role of long noncoding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) anticancer drug has been confirmed. Emerging evidence shown that specific exosomal lncRNAs may serve as meaningful biomarkers. this study, we hypothesize UCA1 might predict response CRC patients.First, cetuximab-resistant cell lines were generated, and expressions...
Alzheimer’s disease (AD) is a common neurodegenerative in elderly individuals, and effective therapies are unavailable. This study was designed to investigate the neuroprotective effects of sulforaphane (an activator NF-E2-related factor 2) on mice with AD-like lesions induced by combined administration aluminum d-galactose. Step-down-type passive avoidance tests showed ameliorated cognitive impairment mice. Immunohistochemistry results indicated attenuated cholinergic neuron loss medial...
Colorectal cancer (CRC) is the third most common malignancy in United States. Chemotherapeutic resistance a massive obstacle for treatment. The roles and molecular basis of long non-coding RNA BRAF-activated noncoding (BANCR) CRC progression adriamycin (ADR) have not been extensively identified. In this study, we found that BANCR CSE1L expressions were upregulated tumor tissues. Meanwhile, expression was correlated with depth CRC. silencing suppressed cell proliferation invasion capacity,...
Abstract Sanguinarine, a bioactive benzophenanthridine alkaloid extracted from plants of the Papaveraceae family, has shown antitumour effects in multiple cancer cells. But therapeutic and regulatory mechanisms sanguinatine gastric (GC) remain elusive. This study was aimed to investigate correlation dual‐specificity phosphatase 4 (DUSP4) expression with clinicopathologic features overall survival patients GC explore sanguinarine on tumour growth invasion cells (SGC‐7901 HGC‐27) underlying...
As an important methyltransferase, G9a has been reported to be abnormally expressed in various human cancers and plays essential roles tumorigenesis. However, the biologic functions molecular mechanisms of gastric cancer (GC) remain unclear. GC is fifth most frequent around world seriously threatens health, especially developing countries. Here, our results showed that high expression was intensively correlated with poor prognosis more advanced stages GCs. Knockdown or treatment its...
Breast cancer is the most commonly diagnosed type of and one leading causes cancer-associated mortality in women. In addition, underlying molecular mechanisms occurrence development breast requires further investigation. present study, bioinformatics analysis was performed to identify differentially expressed genes (DEGs) between normal tissues investigate mechanisms. reverse transcription-quantitative PCR immunohistochemistry (IHC) were protein mRNA expression levels a specific DEG, discs...
TPS315 Background: CRT followed by total mesorectal excision (TME) is the standard care for patients with locally advanced low rectal cancer (≤ 5cm from anal margin). However, TME may lead to permanent colostomy and severely impact quality of life. Organ preservation is, therefore, a critical unmet need these patients. The proportion achieving clinical complete response (cCR) after relatively low, literature reporting around 20%. Total neoadjuvant therapy (TNT) has been investigated increase...
Abstract Aberrant Hedgehog signaling and excessive activation of the Gli family transcriptional activators are key drivers medulloblastoma (MB), most common human pediatric brain malignancy. MB originates mainly from cerebellar granule neuron progenitors (CGNP), but mechanisms underlying CGNP transformation remain largely obscure. In this study, we found that suppression noncoding RNA Nkx2-2as promoted Sonic (Shh)-potentiated development. functioned as a competing endogenous against miR-103...
Ischemia-reperfusion (I/R) is a common clinical process, and the lung one of most sensitive organs I/R injury, which often leads to acute injury (ALI). Tanshinone IIA (Tan IIA) has anti-inflammatory, antioxidant, anti-apoptotic activities. However, effects Tan on remain uncertain. Twenty-five C57BL/6 mice were randomly divided into five groups: control (Ctrl), I/R, + IIA, LY294002 group. (30 μg/kg) was injected intraperitoneally 1 h before in groups. These data showed that significantly...
Abstract The fusion genes NRG1 and NRG2, members of the epidermal growth factor (EGF) receptor family, have emerged as key drivers in cancer. Upon fusion, retains its EGF-like active domain, binds to ERBB ligand triggers intracellular signaling cascades, promoting uncontrolled cell proliferation. incidence gene varies across cancer types, with lung being most prevalent at 0.19 0.27%. CD74 SLC3A2 are frequently observed partners. RNA-based next-generation sequencing is primary method for...
Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide because survival rate remains low. Cell division cycle 5-like (CDC5L) highly expressed in some cells, but mechanism requires clarification. Human telomerase reverse transcriptase (hTERT) plays important roles CRC.This study aimed to identify a link between CDC5L and hTERT determine their effects on signaling pathways, migration prognosis CRC cells. We first treated LoVo cells with biotin-labeled identified...
Chemotherapy after surgery can prolong the survival of patients with gliomas. Dimethylaminomicheliolide (DMAMCL), a novel chemotherapeutic agent, exhibited antitumor properties in acute myeloid leukemia stem cells and showed an increased drug concentration brain. This study aims to investigate specific anticancer activities mechanisms DMAMCL glioma cells.In this study, effects were evaluated characterized U87-MG U251 cells. Cell viability was assessed by Counting Kit-8. Apoptosis,...
It has been widely demonstrated that the hedgehog pathway is strongly associated with basal cell carcinoma of skin (NBCCS). To assess potential DNA alterations related to keratocystic odontogenic tumors (KCOTs), we sequenced smoothened (SMO) genes in 12 sporadic KCOTs. Polymerase chain reaction (PCR), capillary electrophoresis and dideoxy chain-termination sequencing were used examine Five SMO detected. Four these mutations consisted two synonymous three missense mutations; which have not...
Aberrant activation of β-catenin signaling due to low expression miR‑200a is found in gastric carcinoma (GC) tissues promoting GC evolution. Toosendanin (TSN) has exhibited antitumor effects on various human cancer cells, but its influence largely unidentified. The potential roles TSN cells were examined and it was that inhibited growth, migration, invasion TGF‑β1-induced epithelial-mesenchymal transition (EMT) induced cell cycle arrest apoptosis SGC‑7901 which most sensitive among lines....