A5028306916- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Hematological disorders and diagnostics
- Cancer Risks and Factors
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Lymphoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- interferon and immune responses
- Multiple and Secondary Primary Cancers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hematopoietic Stem Cell Transplantation
- Genetic factors in colorectal cancer
- Neurological Complications and Syndromes
Shanghai Jiao Tong University
2017-2024
Twelfth Guangzhou City People's Hospital
2020-2024
Renji Hospital
2010-2023
Jiangmen Central Hospital
2023
Qinghai University
2014-2021
Third Affiliated Hospital of Southern Medical University
2021
Southern Medical University
2021
Qinghai University Affiliated Hospital
2014-2020
University of Benin
2018
Peking University First Hospital
2006
The aim of this study is to explore the roles estrogen receptor (ER) subtypes and corresponding agonists/antagonists on development cirrhosis activation proliferation hepatic stellate cells (HSCs).Carbon tetrachloride (CCl4 )-induced cirrhotic ovariectomized rats were administered non-selective ER agonist (β-estradiol, E2), selective agonists (ERα agonist, propylpyrazoletriol; ERβ diarylpropionitrile [DPN]; G-protein-coupled [GPER] G1), or E2 + antagonists antagonist, MPP; PHTPP; GPER G15)...
Abstract Studies have shown that tumor microenvironment (TME) might affect drug sensitivity and the classification of colorectal cancer (CRC). Using TME-specific gene signature to identify CRC subtypes with distinctive clinical relevance has not yet been tested. A total 18 “bulk” RNA-seq datasets (total n = 2269) four single-cell were included in this study. We constructed a “Signature associated FOLFIRI resistant Microenvironment” (SFM) could discriminate both TME sensitivity. Further, SFM...
The dietary composition has been approved to be strongly associated with the risk of colorectal cancer (CRC), one most serious malignancies worldwide, through regulating gut microbiota structure, thereby influencing homeostasis colonic epithelial cells by producing carcinogens, i.e., ammonia or antitumor metabolites, like butyrate. Though butyrate-producing Fusobacterium nucleatum considered a potential tumor driver chemotherapy resistance and poor prognosis in CRC, it was more frequently...
Abstract A newly identified novel coronavirus (2019-nCoV) has caused numerous acute respiratory syndrome cases in Wuhan China from December 2019 to Feb 2020. Its fast spreading other provinces and overseas is very likely causing a pandemic. Since the been reported be capable of endangering thousands lives, it extremely important find out how transmitted human organs. Apart fever complications, gastrointestinal symptoms are observed some patients with 2019-nCoV but significance remains...
Abstract Chronic mountain sickness (CMS) is a progressive incapacitating syndrome induced by lifelong exposure to hypoxia. In the present study, proteomic analysis was used identify differentially expressed proteins (DEPs) and then evaluate potential plasma biomarkers between CMS non-CMS groups. A total of 145 DEPs were detected in Han Chinese people who live plateau (CMS-HPu), among which 89 significantly up-regulated 56 down-regulated. GO enrichment showed that various biological processes...
Juan Su, Zhanquan Li, Sen Cui, Linhua Ji, Hui Geng, Kexia Chai, Xiaojing Ma, Zhenzhong Bai, Yingzhong Yang, Tana Wuren, Ri-Li Ge, and Matthew T. Rondina. The local HIF-2α/EPO pathway in the bone marrow is associated with excessive erythrocytosis increase microvessel density chronic mountain sickness. High Alt Med Biol. 16:318–330, 2015.—Aim: Chronic sickness (CMS) characterized by erythrocytosis, angiogenesis may be involved pathogenesis of this disease. niche primary site erythropoiesis...
Excessive erythrocytosis (EE) is a characteristic of chronic mountain sickness (CMS). Currently, the pathogenesis CMS remains unclear. This study was intended to investigate role EPAS1 in proliferation erythroblasts CMS. Changes HIF-1α and EPAS1/HIF-2α bone marrow 21 patients with 14 control subjects residing at same altitudes were determined by RT-qPCR western blotting. We also developed lentiviral vector, Lv-EPAS1/sh-EPAS1, over-express/silence K562 cells. Cells cycle detected flow...
Chronic hypoxia (CH) is characterized by long-term that associated with microvessel proliferation and basal membrane (BM) degradation in tissues. The IL-6/JAK2/STAT3/MMP-9 pathway has been described a variety of human cancers plays an essential role BM degradation. Therefore, this study investigated the hypoxia-mediated rat bone marrow. Eighty pathogen-free Sprague Dawley male rats were randomly divided into four groups (20 per group)-control group, CH group (exposed to hypobaric chamber at...
Background: Epithelial-Mesenchymal Transition (EMT) is a major process in the initiation of tumor metastasis, where cancer cells lose sessile epithelial potential and gain mesenchymal phenotype. Large-scale cell identity shifts are often orchestrated on an epigenetic level interplay between factors EMT progression was still largely unknown. In this study, we tried to identify candidate that involved progression. Methods: Colorectal (CRC) were transfected with arrayed shRNA library targeting...
BACKGROUND Chronic mountain sickness (CMS) has a higher incidence in the plateau region. The one of its principal characters is excessive erythrocytosis. PI3K-Akt pathway plays an important role process erythropoiesis, and could downregulate apoptosis by regulating apoptosis-related molecules. In this paper, we explored change erythroblasts effect signal on CMS. MATERIAL AND METHODS A total 22 CMS 20 non-CMS participants were involved study. Bone marrow mononuclear cells cultured treated...
Pregnancy-related gastric cancer is characterized by a refractory nature and poor prognosis; few cases during pregnancy achieved acceptable outcomes using anti-PD-1 as monotherapy. A 32-year-old pregnant female patient was admitted to the emergency department of obstetrics gynecology eventually diagnosed with cancer. Radical surgery for conducted after termination pregnancy. At 1-year postoperative follow-up, tumor recurrence revealed. This has decrease in burden receiving case documents...
Introduction Cytomegalovirus (CMV) can cause various end-organ diseases in immunocompromised hosts, including allogeneic hematopoietic cell transplant (allo-HSCT) recipients. Interestingly, CMV viremia has been associated with complications and poor prognosis allo-HSCT Complications involving the central nervous system (CNS) occur 9–14% of patients following allo-HSCT. However, autoimmune encephalitis (AE) secondary to infection after rarely reported. Here we report a case possible AE...
Background: Many studies have indicated that autophagy plays an important role in multiple cancers, including hepatocellular carcinoma (HCC). This study aimed to establish a prognostic signature for HCC based on autophagy-related genes (ARGs) predict the prognosis of patients.
To investigate the therapeutic efficacy of rituximab combined with methotrexate on patients primary central nervous system lymphoma.Fifty eight lymphoma treated in our hospital from February 2008 to September 2011 years were randomly divided into observation group and control group. The was whole brain radiotherapy; by methotrexate. curative efficacy, adverse effects, life quality, 1 3 year survival rate after 2 cycles treatment compared between groups.The total effective 82.76%, which...
Portal hypertension (PHT) is primarily caused by an increase in resistance to portal outflow and secondarily splanchnic blood flow. Vascular hyporeactivity both systemic circulation the mesenteric artery plays a role hyperdynamic circulatory syndrome.To explore gender differences of endogenous sex hormones PHT vascular reactivity arterioles rats.Cirrhosis were established subcutaneous injection carbon tetrachloride (CCl4) male female integral castrated rats (ovariectomized [OVX] rats,...
To explore the influence of GATA-1 on expression EpoR in bone marrow CD71+ cells rat model with high altitude polycythemia (HAPC).Forty-eight male SD rats were randomly divided into normal control and HAPC group. was established at 4 300 meters natural environment, verified by cell counts hematological parameters. Myeloid separated density gradient centrifugation combined magnetic activated sorting. The membrane detected flow cytometry immunofluorescence. changes mRNA protein Q-PCR Western...