A5026264090- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- CAR-T cell therapy research
- Pneumocystis jirovecii pneumonia detection and treatment
- T-cell and Retrovirus Studies
- Immune cells in cancer
- Mesenchymal stem cell research
- Neutropenia and Cancer Infections
- Antifungal resistance and susceptibility
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Chemokine receptors and signaling
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
Shanghai First People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Second Military Medical University
2024
Weatherford College
2024
Changhai Hospital
2024
Shanghai Cell Therapy Research Institute
2022-2023
Zhejiang Ocean University
2023
Minhang District Central Hospital
2022
Southwest Jiaotong University
2020-2022
Fudan University
2022
For recipients of allogeneic hematopoietic stem-cell transplantation (alloHSCT), we hypothesized that prophylactic therapy during neutropenia with granulocyte-macrophage colony-stimulating factor (GM-CSF) decreases invasive fungal disease (IFD).We randomly assigned 206 patients undergoing alloHSCT to receive once-daily subcutaneous GM-CSF (5 7 μg/kg per day), granulocyte (G-CSF; 5 or a combination G-CSF and (2 3 day each). Treatment was started on after continued until the absolute...
Nowadays, the most wildly used regimens for graft-versus-host disease (GvHD) prophylaxis in haplo-hematopoietic stem cell transplantation (Haplo-HSCT) are based on vivo T-cell depletion (TCD) with anti-thymocyte globulin (ATG) or posttransplant cyclophosphamide (PTCy). To improve efficiency of GvHD haploidentical peripheral blood combined unrelated cord (Haplo-PBSCT-Cord), a novel regimen, which is composed low dose ATG (5 mg/kg) and low-dose PTCy (50 prophylaxis, was evaluated prospective...
In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or drug to treat COVID-19, positive results passive immune therapy using convalescent serum provide strong lead. We have developed new class tetravalent, biparatopic therapy, 89C8-ACE2. It combines specificity monoclonal antibody (89C8) that recognizes relatively conserved N-terminal domain viral Spike (S) glycoprotein, and ectodomain ACE2, which binds receptor-binding S. This molecule shows exceptional...
Layer-by-layer dissolution and permeable pore formation are two typical membrane damage pathways, which induce function disorder result in serious disease, such as Alzheimer's Keshan Sickle-cell so on. To effectively distinguish sensitively monitor these a facile electrochemical impedance strategy was developed on porous self-assembly monolayer (pSAM) supported bilayer lipid (BLM). The pSAM prepared by selectively reductive desorption of the mercaptopropionic acid mixed...
Introduction The novel low-dose anti-thymocyte (ATG, 5 mg/kg) plus post-transplant cyclophosphamide (PTCy, 50 (low-dose ATG/PTCy)-based regimen had promising activity for prevention of graft-versus-host disease (GVHD) in haploidentical-peripheral blood stem cell transplantation (haplo-PBSCT), but its impacts on long-term outcomes remain to be defined. Methods We performed a large sample, follow-up retrospective study evaluate efficacy GVHD prophylaxis. Results enrolled 260 patients,...
The standard regimens for graft-versus-host disease (GvHD) prophylaxis in matched unrelated donor (MUD) transplantation were based on antithymocyte globulin (ATG) combination with calcineurin inhibitors (CNIs). To improve the efficiency of GvHD MUD peripheral blood stem cell (MUD-PBSCT), 51 patients hematological malignancies received a novel regimen prophylaxis, which is composed low dose ATG (5 mg/kg) plus low-dose posttransplant cyclophosphamide (PTCy, 50 (low-dose ATG/PTCy) combined...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the consolidation modalities for adult patients with T-cell lymphoblastic lymphoma (T-LBL). However, optimal conditioning regimen needs to be explored. In present study, 40 T-LBL undergoing allo-HSCT were retrospectively analyzed, including 23/40 (57.5%) total body irradiation (TBI)–based and 17/40 (42.5%) busulfan (BU)-based regimen. TBI–based significantly increased cumulative incidence (CI) grade II IV acute...
To evaluate the interactive association between obesity with different anthropometry indices and prevalence of hypertension in rural Lanzhou.A cross-sectional survey was conducted Lanzhou from April to July 2013. The available information 1275 residents aged more than 35 years collected a unified questionnaire their blood pressure were measured field. male-to-female ratio 1:1.1. A generalized estimate equation (GEE) linear model used determine indexes hypertension.There moderate general...
The complex mechanistic array underlying the pathogenesis of myelodysplastic syndrome (MDS) is still unclear. Although dysregulations different signaling pathways involved in MDS have been described, identification specific biomarkers and therapy targets remains an important task order to establish novel therapeutic approaches. Here, we demonstrated that Shh pathway active correlated it with disease progression. Additionally, knockdown Gli1 significantly inhibited cell proliferation vitro...
Bacterial infections are very common among patients with hematological diseases. Scant data available regarding differences in the epidemiology and biological features of bacterial neutropenic non-neutropenic patients.The aim this survey was to compare pathogens same ward during an 8-year period.A total 1139 strains were isolated from 1071 The percentage Gram-negative bacteria significantly higher than (70.4% vs. 55.0%, respectively, P < .01). In patients, most commonly-isolated bacterium...
In this study we investigated the correlation between donor chimerism status and disease relapse following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The of Fluorescence-activated sorter (FACS) sorted CD3+T lymphocytes 153 cases, CD56+CD16+NK cases CD19+B 31 with acute B lymphoblastic leukemia (B-ALL) was analyzed post-transplant utilizing polymerase chain reaction amplification short tandem repeats (PCR-STR). A total 33 patients (33/153, 21.6%) had recurrent disease....
Viral reactivation or infections are common complications after allogeneic hematopoietic stem cell transplantation, especially in haploidentical transplantation. Here, we presented a young patient with Ph-like acute lymphoblastic leukemia who suffered Epstein-Barr virus (EBV) encephalitis and disseminated adenovirus (ADV) infection peripheral blood (PB) The was 16-year-old boy received PB cells from his HLA-haploidentical matched father. On day +44 he had viremia cytomegalovirus, EBV...
Maternal and collateral donors were associated with a higher incidence of graft-
Acute myeloid leukemia (AML) is a prevalent hematological malignancy among adults. Recent studies suggest that the length of telomeres could significantly affect both risk developing AML and overall survival (OS). Despite limited focus on prognostic value telomere-related genes (TRGs) in AML, our study aims at addressing this gap by compiling list TRGs from TelNet, as well collecting clinical information expression data through Gene Expression Omnibus (GEO) database. The GSE37642 dataset,...
Introduction Cytomegalovirus (CMV) can cause various end-organ diseases in immunocompromised hosts, including allogeneic hematopoietic cell transplant (allo-HSCT) recipients. Interestingly, CMV viremia has been associated with complications and poor prognosis allo-HSCT Complications involving the central nervous system (CNS) occur 9–14% of patients following allo-HSCT. However, autoimmune encephalitis (AE) secondary to infection after rarely reported. Here we report a case possible AE...
Posttransplant lymphoproliferative disorder (PTLD) is a rare lymphoid and/or plasmocytic proliferation that occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We aimed to identify the pathologic features and clinical outcomes of T-cell PTLD, an extremely subtype allo-HSCT. In this study, six allo-HSCT recipients with PTLD from five transplant centers in China were enrolled. All donor-derived, three patients monomorphic polymorphic types, respectively. received...
Summary This prospective clinical study aimed to evaluate the efficacy and safety of pre‐emptive treatment modality azacitidine in combination with interferon‐α (IFN‐α) AML/MDS patients post‐transplantation. Forty‐seven aged 17–62 were enrolled 14 having completed planned 12 cycles. Following initiation, 72.3% responded positively after first cycle, peaking at 77.2% by fifth cycle. Notably, 24 maintained sustained responses throughout a median follow‐up 1050 days (range, 866–1234). Overall...