A5006147747- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Anesthesia and Pain Management
- Immune Cell Function and Interaction
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Transplantation Techniques and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Anesthesia and Sedative Agents
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Cancer Immunotherapy and Biomarkers
- Atrial Fibrillation Management and Outcomes
- Phagocytosis and Immune Regulation
- Tracheal and airway disorders
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Circular RNAs in diseases
- Cancer Cells and Metastasis
Mianyang Third People's Hospital
2025
Renji Hospital
2007-2024
Shanghai Jiao Tong University
2008-2024
First Affiliated Hospital of Zhengzhou University
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2023
Jiangsu University
2018-2023
Second Affiliated Hospital of Zhejiang University
2023
Ruijin Hospital
2021
Shanghai Chest Hospital
2012-2021
Shangqiu First People's Hospital
2019-2021
Colorectal cancer (CRC) is one of the most common causes cancer-related death worldwide due to distant metastases. Compelling evidence has reported that epithelial-mesenchymal transition (EMT) involved in promoting invasion and metastasis. However, precise molecular events initiate this complex EMT process remain poorly understood. Here, we showed pleiotropic cytokine interleukin-13 (IL-13) could induce an aggressive phenotype displaying by enhancing expression EMT-promoting factor ZEB1....
Colorectal cancer (CRC) is the second leading cause of deaths worldwide, and metastasis principle reason for its poor prognosis. Overexpression high-mobility gene group A2 (HMGA2) contributes to aggressiveness CRC. However, underlying molecular mechanism overexpression still elusive. In this study, we showed that ectopic expression HMGA2 significantly enhanced cell migration invasion in vitro promoted tumor growth distant vivo . contrast, silencing produced opposite effects Chromatin...
Dangguiliuhuang decoction (DGLHD) has been demonstrated to be effective in treating inflammatory, hepatic steatosis, and insulin resistance. In the study, we tried elucidate pharmacological efficacy mechanism of DGLHD against liver fibrosis predicate potential active ingredients targets via network analysis experimental validation. formula, totally discovered 76 like baicalein, berberine, wogonin, 286 corresponding including PTGS (prostaglandin-endoperoxide synthase) 2, PPAR (peroxisome...
Background:Morus alba L. (Sangzhi) alkaloids (SZ-A), extracted from the Chinese herb Morus (mulberry twig), have been shown to ameliorate hyperglycemia in type 2 diabetes and approved for treatment clinic. However, their versatile pharmacologic effects regulatory mechanisms are not yet completely understood. Purpose: This study explored protective of SZ-A on islet β cells underlying mechanism. Methods: Type diabetic KKAy mice were orally administered (100 or 200 mg/kg, once daily) 11 weeks,...
To investigate the effects of sufentanil on immune response, pain mediators and brain-sparing effect in patients with breast cancer undergoing radical mastectomy. This study was a single center retrospective cohort study. The 118 subjects were diagnosed treated our hospital from period January 2020-October 2022, who planned to undergo surgery for cancer. According different surgical drugs, these divided into group control group, 59 cases each. visual analog scores (VAS) two groups compared...
Abstract The regenerating islet-derived gene was first isolated in regenerated pancreas tissues, greatly contributing to β cell regeneration. It is an anti-inflammatory response cellular stress. This encouraged us investigate the exact role of a novel member Reg family, γ, type 1 diabetes nonobese-diabetic mice. For this, Reg3g overexpressed pancreatic islets, and conferred beneficial effects on regeneration through activating Janus kinase 2/signal transducer activator transcription...
Cooperating mercapto groups with tacrine in a single molecular, novel multifunctional compounds have been designed and synthesized. These mercapto-tacrine derivatives displayed synergistic pharmacological profile of long-term potentiation enhancement, cholinesterase inhibition, neuroprotection, less hepatotoxicity, emerging as promising molecules for the therapy age-related neurodegenerative diseases.
Abstract Reg3g is a potential risk for pancreatic ductal adenocarcinoma (PDAC). We previously demonstrated that promoted carcinogenesis via STAT3 signaling pathway in murine model of chronic pancreatitis. Whether the immune response involved tumorigenesis induced by remains unknown. In this study, Reg3g-regulated tumor immunity was evaluated tumor-implanted models, cells, and microenvironment. mice had been orthotopically or ectopically implanted with Panc02 overexpression increased EGFR...
Abstract In traditional Chinese medicine (TCM), Dangguiliuhuang decoction (DGLHD) is an effective treatment of autoimmune diabetes. Here, we studied potential anti-diabetic mechanisms DGLHD in a non-obese diabetic (NOD) mouse model. vitro, and individual active ingredients enhanced glucose uptake HepG2 cells, inhibited T lymphocyte proliferation suppressed dendritic cells (DCs) function. vivo , significantly insulitis, delayed the onset development diabetes, promoted insulin secretion...
Innate immune cells in the tumor microenvironment have been proposed to control transition from benign malignant stages. In many cancers, increased infiltration of natural killer (NK) associates with good prognosis. Although mechanisms that enable NK restrain colorectal cancer (CRC) are unclear, current study suggests involvement Smad4. We found suppressed Smad4 expression circulating untreated metastatic CRC patients. Moreover, cell-specific deletion promoted colon adenomas DSS-treated Apc...
Berberine is effective for type 2 diabetes mellitus (T2DM), but has limited use in clinic. This study aims to evaluate the effect of berberine combined with stachyose on glycolipid metabolism and gut microbiota explore underlying mechanisms diabetic rats.
We previously reported that total coumarins, the major active components of <i>Urtica dentata</i> Hand, exhibited substantial protection against development autoimmune diabetes. Diabetic nephropathy is one most serious complications diabetes and closely correlated with end-stage renal disease. used rat glomerular mesangial cell line (HBZY-1) streptozotocin-induced diabetic rats to investigate potential protective effects mechanisms coumarins on Our data revealed inhibited high...
Morus alba L. (Sangzhi) alkaloid (SZ-A) is a new antidiabetic drug approved by the China National Medical Products Administration in 2020. Diabetic nephropathy (DN) common diabetic complication and an important cause of morbidity mortality patients with diabetes. The effects SZ-A on DN remain unknown. This study evaluated Zucker fatty (ZDF) rats explored underlying mechanisms based nitrosative stress, inflammation, fibrosis. ZDF were orally administered 100 200 mg/kg once daily for 9 weeks....