A5072219852- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Metastasis and carcinoma case studies
- Pleural and Pulmonary Diseases
- Myasthenia Gravis and Thymoma
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Cardiac Arrhythmias and Treatments
- Meningioma and schwannoma management
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Cancer-related gene regulation
- Actinomycetales infections and treatment
- interferon and immune responses
- Chromatin Remodeling and Cancer
- Congenital Diaphragmatic Hernia Studies
- Thyroid and Parathyroid Surgery
Shanghai Chest Hospital
2014-2024
Shanghai Jiao Tong University
2013-2024
Ningbo University
2022
Liuzhou Maternal and Child Health Hospital
2021
Tiangong University
2021
Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), has been approved for EGFR-mutant non-small-cell lung cancer (NSCLC). We aimed to evaluate the efficacy and safety of neoadjuvant osimertinib in patients with resectable locally advanced NSCLC.This single-arm, phase 2b trial (ChiCTR1800016948) was conducted at six centers mainland China. Patients measurable stage IIA-IIIB (T3-4 N2) adenocarcinoma EGFR exon 19 and/or 21 mutations were...
The incidence of lung cancer is increasing worldwide. Although great progress in treatment has been made, the clinical outcome still unsatisfactory. Tripartite motif (TRIM)-containing proteins shown to be closely related tumor progression. However, function TRIM46 largely unknown. Here, amplification was found adenocarcinoma (LUAD) tissues and significantly associated with a poor survival rate. Overexpression wild type increased proliferation LUAD cells glycolysis, promoted xenografts...
Limited resections for early stage lung cancer have been of increasing interests recently. However, it is still unclear to what extent a limited resection could preserve pulmonary function comparing standard lobectomy, especially in the context minimally invasive surgery. The purpose this study was evaluate postoperative changes spirometry patients undergoing video-assisted thoracic surgery (VATS) lobectomy or resections.Spirometry tests were obtained prospectively before and 6 months after...
Thoracoscopic segmentectomy is increasingly used in the surgical treatment of early-stage non-small cell lung cancer. However, it remains unclear whether pulmonary function loss after thoracoscopic resection direct proportion to number resected segments, and thus intentional has function-preserving advantage over lobectomy.In this prospective observational study, spirometry tests were performed preoperatively 6 months postoperatively. The observed functional was compared with expected...
Lung adenocarcinoma (LUAD) is a heterogeneous disease. Our study aimed to understand the unique molecular features of preinvasive invasive LUAD subtypes. We retrospectively analyzed clinical, histopathological, and data 3,254 Chinese patients with lesions (n = 252), minimally adenocarcinomas 479), 2,523). Molecular were elucidated using targeted 68-gene next-generation sequencing panel. findings revealed four lesion-predominant gene mutations, including MAP2K1 insertion-deletions (indels),...
To compare surgical outcomes of thoracoscopic and laparoscopic esophagectomy with open in order to study the learning curve minimally invasive surgery for esophageal cancers.Among 109 cancer patients retrospectively studied, 59 underwent (MIE) 50 (OE). In MIE group, first 30 received hybrid procedures, including 16 esophagectomies 14 maneuvers. The later 29 thoraco-laparoscopic (TLE).The overall morbidity OE was 42.4% (25/59) 44.0% (22/50), respectively, no statistical difference. However,...
Background: To assess the feasibility and perioperative outcomes of single-port (SP) multi-port (MP) approaches for video-assisted thoracoscopic surgery (VATS) lobectomy anatomical segmentectomy. Methods: Retrospective data from 458 patients who received VATS or segmentectomy at Shanghai Chest Hospital, Korea University Guro Affiliated Hospital National Taiwan University, Hong Kong Queen Mary Shenzhen were collected. Patients divided into SP group MP according to surgical approach....
Despite increasingly radical surgery for esophageal carcinoma, many patients still develop tumor recurrence after operation. This study was designed to analyze the clinical and pathologic influencing factors of early in with histological node-negative (pN0 stage) squamous cell carcinoma (ESCC) esophagectomy.
Indication for sublobar resections in early-stage lung adenocarcinomas has been controversial. The purpose of this study was to find appropriate selection criteria ground glass opacity (GGO)-containing adenocarcinomas.
AIM: To compare lymph node dissection results of minimally invasive esophagectomy (MIE) and open surgery for esophageal squamous cell carcinoma.METHODS: We retrospectively reviewed data from patients who underwent MIE or carcinoma January 2011 to September 2014.Number nodes resected, positive (pN+) rate, sampling (LNS) rate metastatic (LNM) were evaluated.RESULTS: Among 447 included, 123 324 surgery.The number resected did not significantly differ between the groups (21.1 ± 4.3 vs 20.4 3.8,...
Energy management strategies can improve fuel cell hybrid electric vehicles’ dynamic and economy, the based on model prediction control show great advantages in optimizing power split effect real time. In this paper, influence of horizon error, consumption, time was studied detail. The framework energy strategy proposed terms theory. radial basis function neural network presented as predictor to obtain short‐term velocity future. A programming algorithm applied optimized laws horizon....
Background: Video-assisted thoracoscopic surgery (VATS) has been increasingly used in the treatment of lung cancers. But it is still unclear whether mediastinal lymph node dissection (LND) under VATS safe and feasible. The aim this study to figure out LND by
Background The safety, feasibility, and prognosis of sleeve lobectomy by minimally invasive surgery (MIS) remain to be validated. purpose this study was investigate outcomes in real-world patients receiving a balanced large cohort. Methods Between January 2013 December 2018, 578 consecutive undergoing resection at high-volume center were retrospectively analyzed. Surgical oncologic compared between MIS thoracotomy after propensity-score matching (PSM). Results increasingly used as time-trend...
The 7th edition Union for International Cancer Control esophageal cancer staging system has changed the pathological N stage from N0, N1 (the existence state of regional lymph node metastasis) to N1, N2, and N3 (number metastasis). This study was designed analyze influencing factors early recurrence in patients with (pN1 stage) squamous cell carcinoma (ESCC) after radical esophagectomy.A retrospective 95 consecutive pN1 ESCC conducted. Cox proportional hazards model used determine...
Esophageal squamous incidence in many developed countries has increased dramatically over last decades, while the underlying mechanism of biogenesis ES was still unknown.Here, we investigate 1001 subjects with esophageal cancer recruited from affiliated hospital Shanghai Jiao Tong University Jan. 1, 2001 to Feb. 2, 2004. Single nucleotide polymorphism (SNP) alcohol dehydrogenase-1B (ADH1B) performed, and recombinant plasimd containing ADH1B constructed. Then, purified enzymatic activity...
Phrenic nerve injury (PNI) during lung cancer surgery, without apparent section or damage, is still not well-studied. The aim of our study to find an easy and objective way evaluate a significant diaphragm elevation (SDE) suggestive inadvertent PNI its incidence impact on patients undergone video-assisted thoracoscopic surgery (VATS) lobectomy.Extent was first examined chest X-ray in cohort with invasive thymoma whom phrenic intentionally transected. result then used as the criterion...
Lung cancer is one of the central causes tumor-related deaths globally, which non-small cell lung (NSCLC) takes up about 85%. As key regulators various biological processes, microRNAs (miRNAs) have been verified as crucial factors in NSCLC. To elucidate role miR-486-5p mTOR pathway, we investigated its NSCLC and related signaling. Our results confirmed that was downregulated most human tissue samples lines. Further study it inhibited through repression pathway via targeting both ribosomal...