A5101742542- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Dermatology and Skin Diseases
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Pharmacological Effects of Natural Compounds
- Adenosine and Purinergic Signaling
- Neurotransmitter Receptor Influence on Behavior
- Immune Cell Function and Interaction
- Cancer, Stress, Anesthesia, and Immune Response
- Peripheral Neuropathies and Disorders
- Liver Disease and Transplantation
- Immune cells in cancer
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Vagus Nerve Stimulation Research
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Cognitive and developmental aspects of mathematical skills
- Conducting polymers and applications
- Reproductive Biology and Fertility
- Mathematics Education and Teaching Techniques
Nanchang University
2019-2023
Hangzhou Normal University
2023
Rutgers, The State University of New Jersey
2019-2022
Mayo Clinic
2017-2019
WinnMed
2019
Institute of Electrical and Electronics Engineers
2018
Sichuan Agricultural University
2014
Abstract Microglia are important immune cells in the central nervous system (CNS) that undergo turnover throughout lifespan. If microglial debris is not removed a timely manner, accumulated may influence CNS function. Clearance of crucial for homeostasis. However, underlying mechanisms remain obscure. We here investigate how dead microglia removed. find although can phagocytose vitro, territory-dependent competition hinders microglia-to-microglial engulfment vivo. In contrast, mainly...
The P2Y12 receptor (P2Y12R) is a purinoceptor that selectively expressed in microglia the central nervous system. As signature receptor, microglial P2Y12R mediates process chemotaxis towards ADP/ATP gradients and engaged several neurological diseases including chronic pain, stroke seizures. However, role of regulating neuronal excitability innate behaviors not fully understood. Here, we generated P2Y12-floxed mice to delete beginning development (CX3CR1Cre/+:P2Y12f/f; "constitutive...
Seizures are common in humans with various etiologies ranging from congenital aberrations to acute injuries that alter the normal balance of brain excitation and inhibition. A notable consequence seizures is induction aberrant neurogenesis increased immature neuronal projections. However, regulatory mechanisms governing these features during epilepsy development not fully understood. Recent studies show microglia, brain's resident immune cell, contribute regulate seizure phenotypes. role...
Microglia have been shown to be of critical importance the progression temporal lobe epilepsy. However, broad transcriptional changes that these cells undergo following seizure induction is not well understood. As such, we utilized RNAseq analysis upon microglia isolated from hippocampus determine expression pattern alterations kainic acid induced seizure. We determined dramatic their patterns, particularly with regard mitochondrial activity and metabolism. also observed initiate...
Abstract Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial processes interact with neuronal elements constantly on order minutes. The functional significance this acute microglia-neuron interaction and its potential role in context pain is still largely unknown. Here, we found that spinal microglia increased their process motility electrophysiological reactivity within an hour after insult a mouse model formalin-induced acute, sustained, inflammatory...
Although itch and pain have many similarities, they are completely different in perceptual experience behavioral response. In recent years, we a deep understanding of the neural pathways sensation transmission. However, there few reports on role non-neuronal cells itch. Microglia known to play key chronic neuropathic acute inflammatory pain. It is still unknown whether microglia also involved regulating transmission sensation. present study, used several kinds transgenic mice specifically...
The “number sense” describes the intuitive ability to quantify without counting. Single neuron recordings in non-human primates and functional imaging humans suggest intraparietal sulcus is an important neuroanatomical locus of numerical estimation. Other lines inquiry implicate IPS numerous other functions, including attention decision making. Here we provide a direct test whether has specificity for numerosity judgments. We used muscimol reversibly independently inactivate ventral lateral...
SUMMARY Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial processes interact with neuronal elements constantly on order minutes. The functional significance this acute microglia-neuron interaction and its potential role in context pain is still largely unknown. Here, we found that spinal microglia increased their process motility electrophysiological reactivity within an hour after insult a mouse model formalin-induced acute, sustained, inflammatory...
Abstract Cannabis is an annual herb of the genus Cannabis, with a history medical use going back thousands years. However, its abuse causes many side-effects, including confusion consciousness, alienation, and mental disorders such as schizophrenia depression. Research conducted on rodents suggests that there are two types cannabinoid receptors - receptor 1 (CB1R) 2 (CB2R). CB1R found mostly in central nervous system, particularly prefrontal cortex (PFC), alterations expression PFC have been...
Although itch and pain have many similarities, they are completely different in perceptual experience behavioral response. In recent years, we a deep understanding of the neural pathways sensation transmission. However, there few reports on role non-neuronal cells itch. Microglia known to play key chronic neuropathic acute inflammatory pain. It is still unknown whether microglia also involved regulating transmission sensation. present study, used several kinds transgenic mice specifically...
Abstract Although itch and pain have many similarities, they are completely different in perceptual experience behavioral response. In recent years, we a deep understanding of the neural pathways sensation transmission. However, there few reports on role non-neuronal cells itch. Microglia known to play key chronic neuropathic acute inflammatory pain. It is still unknown whether microglia also involved regulating transmission sensation. present study, used several kinds transgenic mice...