A5106282851- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Spinal Cord Injury Research
- Retinal Development and Disorders
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
Fudan University
2021-2024
State Key Laboratory of Medical Neurobiology
2021-2024
Huashan Hospital
2021-2022
Jinshan Hospital of Fudan University
2022
Abstract As important immune cells, microglia undergo a series of alterations during aging that increase the susceptibility to brain dysfunctions. However, longitudinal characteristics remain poorly understood. In this study, we mapped transcriptional and epigenetic profiles from 3- 24-month-old mice. We first discovered unexpected sex differences identified age-dependent (ADEM) genes process. then compared features reactivity in female at single-cell resolution level. To dissect functions...
Abstract Microglia are important immune cells in the central nervous system (CNS) that undergo turnover throughout lifespan. If microglial debris is not removed a timely manner, accumulated may influence CNS function. Clearance of crucial for homeostasis. However, underlying mechanisms remain obscure. We here investigate how dead microglia removed. find although can phagocytose vitro, territory-dependent competition hinders microglia-to-microglial engulfment vivo. In contrast, mainly...
Abstract Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited. Microglia is the resident immune cells system, play critical role in spinal injury. Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead and debris releasing neuroprotective anti-inflammatory factors. However, excessive activation lead to persistent inflammation contribute formation glial scars, hinder axonal...