A5014697329- Enzyme function and inhibition
- Seed Germination and Physiology
- Synthesis and Catalytic Reactions
- Advanced MRI Techniques and Applications
- Plant Molecular Biology Research
- Retinal Diseases and Treatments
- Outsourcing and Supply Chain Management
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Prion Diseases and Protein Misfolding
- Cancer Mechanisms and Therapy
- Nitric Oxide and Endothelin Effects
- Endoplasmic Reticulum Stress and Disease
- EEG and Brain-Computer Interfaces
- Liver Disease Diagnosis and Treatment
- Soybean genetics and cultivation
- Chromatography in Natural Products
- Alzheimer's disease research and treatments
- Law, logistics, and international trade
- Legume Nitrogen Fixing Symbiosis
- Retinal Development and Disorders
- Traditional Chinese Medicine Analysis
- Magnetic and Electromagnetic Effects
- Cholinesterase and Neurodegenerative Diseases
Shandong University
2022-2024
Institut Agro Rennes-Angers
2020-2024
Tianjin Medical University General Hospital
2011-2023
Zhengzhou University
2016-2023
Nankai University
2014-2022
Zhejiang Gongshang University
2022
University of Florida
2012-2021
The Seventh Affiliated Hospital of Sun Yat-sen University
2020-2021
Sun Yat-sen University
2020-2021
L'Institut Agro
2021
Background . Accumulative evidence showed that gut microbiota was important in regulating the development of nonalcoholic fatty liver disease (NAFLD). Hugan Qingzhi tablet (HQT), a lipid‐lowering and anti‐inflammatory medicinal formula, has been used to prevent treat NAFLD. However, its mechanism action is unknown. The aim this study confirm whether HQT reversed dysbiosis NAFLD rats. Methods We established an model rats fed with high‐fat diet (HFD), which given different interventions,...
Abstract β‐Secretase (BACE1) is a major drug target for combating Alzheimer's disease (AD). Here we show that BACE1 −/− mice develop significant retinal pathology including thinning, apoptosis, reduced vascular density and an increase in the age pigment, lipofuscin. expression highest neural retina while BACE2 was greatest pigment epithelium (RPE)/choroid. Pigment epithelial‐derived factor, known regulator of γ‐secretase, inhibits endothelial growth factor (VEGF)‐induced vitro vivo...
Summary Many plants sense the seasonal cues, day length or photoperiod changes, to align timing of developmental transition flowering with changing seasons for reproductive success. Inductive lengths through pathway induce expression FLOWERING LOCUS T ( FT ) relatives that encode a major mobile florigen promote flowering. In Arabidopsis thaliana , under inductive long days output CONSTANS CO accumulates toward end day, and associates B C subunits Nuclear Factor Y NF ‐Y) form ‐ complex acts...
Carbonic anhydrase IX (CAIX) and XII (CAXII) are transmembrane proteins that associated with cancer progression. We have previously described the catalytic properties of CAIX in MDA-MB-231 breast cells, a line cells were derived from patient triple negative cancer. chose this because expression is marker hypoxia prognosticator for reduced survival. However, CAXII better survival statistics than those patients low expression. Yet similar activities. Here we compare potential roles context...
Introduction Increased neutrophil extracellular trap (NET) formation has been reported to be associated with cerebrovascular dysfunction and neurological deficits in traumatic brain injury (TBI). However, the biological function underlying mechanisms of NETs TBI-induced neuronal cell death are not yet fully understood. Methods First, tissue peripheral blood samples TBI patients were collected, infiltration was detected by immunofluorescence staining Western blot. Then, a controlled cortical...
Although anti-vascular endothelial growth factor (VEGF) treatments reduce pathological neovascularization in the eye and tumors, regression is often not sustainable or incomplete. We investigated whether vascular cells circumvent anti-VEGF therapies by activating unfolded protein response (UPR) to override classic extracellular VEGF pathway. Exposure of VEGF, high glucose, H2O2 up-regulated X-box binding protein-1/inositol-requiring protein-1 (IRE1) α transcription 6 (ATF6) arms UPR compared...
Carbonic anhydrases (CAs) have been linked to tumor progression, particularly membrane-bound CA isoform IX (CA IX). The role of in the context breast cancer is regulate pH microenvironment. In contrast IX, expression XII, specifically cancer, associated with better outcome despite performing same catalytic function. this study, we structurally modeled orientation bound ureido-substituted benzene sulfonamides (USBs) within active site comparison and cytosolic off-target II, understand...
// Jikui Sun 1, * , Zhifan Jia 2, Banban Li 3, Anling Zhang 2 Guangxiu Wang Peiyu Pu Zhijuan Chen Zengguang and Weidong Yang 1 Department of Neurosurgery, Affiliated Hospital Taishan Medical University, Life Science Research Center Taian, 271000, P.R. China Tianjin University General Hospital, Neurological Institute, Key Laboratory Post-trauma Neuro-repair Regeneration in Central Nervous System, Ministry Education, Injuries, Variations Tianjin, 300052, 3 Hematopathology, These authors...
The most aggressive and invasive tumor cells often reside in hypoxic microenvironments rely heavily on rapid anaerobic glycolysis for energy production. This switch from oxidative phosphorylation to glycolysis, along with up-regulation of the glucose transport system, significantly increases release lactic acid into microenvironment. Excess lactate proton excretion exacerbate extracellular acidification which cancer cells, but not normal adapt. We have hypothesized that carbonic anhydrases...
Grain legumes are highly valuable plant species, as they produce seeds with high protein content. Increasing seed production and improving nutritional quality represent an agronomical challenge in order to promote consumption of a growing population. In this study, we used the genetic diversity, naturally present Medicago truncatula, model for legumes, identify genes/loci regulating traits. Indeed, using sequencing data 162 accessions from HAPMAP collection, performed genome-wide association...
Objective To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on local analysis methods regional homogeneity (ReHo), amplitude low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs). Methods A total 42 consecutive patients with focal epilepsy were enrolled. Sensitivity, specificity, positive predictive (PPV), negative (NPV) visually assessed RS-fMRI, MRI, spectroscopy (MRS), video...
Abstract Phase separation of multivalent protein and RNA molecules enables cells the formation reversible nonstoichiometric, membraneless assemblies. These assemblies, referred to as biomolecular condensates, help with spatial organization compartmentalization cellular matter. Each condensate is defined by a distinct macromolecular composition. Distinct condensates have preferential locations within cells, they are associated biological functions, including DNA replication, metabolism,...
Purpose.: This study aimed to determine whether upregulation of γ-secretase could inhibit laser-induced choroidal neovascularization (CNV) and if this was associated with a reduction in both oxidative stress proinflammatory cytokines. Methods.: γ-Secretase, or its catalytic subunit presenilin 1 (PS1), were upregulated by exposure either pigment epithelial derived factor (PEDF) an AAV2 vector containing PS1 gene driven vascular endothelial-cadherin promoter. Retinal endothelial cells infected...
Temozolomide (TMZ), as the first-line chemotherapeutic agent for treatment of glioblastoma multiforme (GBM), often fails to improve prognosis GBM patients due quick development resistance. The need more effective management is urgent. aim this study evaluate efficacy combined therapy with TMZ and amlexanox, a selective inhibitor IKBKE, GBM. We found that resulted in significant induction cellular apoptosis inhibition cell viability, migration, invasion primary glioma cells human line, U87...
Human cell lines are an important resource for research, and often used as in vitro models of human diseases. In response to the mandate that all cells should be authenticated, we discovered MDA-MB-231 were use our lab, did not validate based on alleles 9 different markers (STR Profile). We had been using this line a model triple negative breast cancer (TNBC) has ability form tumors immuno-compromised mice. Based marker analysis, these most closely resembled MCF10A line, which near diploid...