A5101622951- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cholesterol and Lipid Metabolism
- T-cell and B-cell Immunology
- Drug Transport and Resistance Mechanisms
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Metabolomics and Mass Spectrometry Studies
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Lipid metabolism and disorders
- Receptor Mechanisms and Signaling
- Cell Adhesion Molecules Research
- Gut microbiota and health
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Cytokine Signaling Pathways and Interactions
- Sphingolipid Metabolism and Signaling
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
- Alcohol Consumption and Health Effects
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Viral Infectious Diseases and Gene Expression in Insects
Shantou Central Hospital
2017-2024
Southern Medical University
2015-2020
Zhujiang Hospital
2015-2020
Sun Yat-sen University
2020
Novartis (United States)
2016
University of Rochester
1992-2015
Shihezi University
2013-2015
Xinjiang Production and Construction Corps
2015
Merck & Co., Inc., Rahway, NJ, USA (United States)
2012-2014
American Red Cross
1995-1997
Dietary cholesterol consumption and intestinal absorption contribute to plasma levels, a risk factor for coronary heart disease. The molecular mechanism of sterol uptake from the lumen small intestine is poorly defined. We show that Niemann-Pick C1 Like 1(NPC1L1) protein plays critical role in cholesterol. NPC1L1 expression enriched brush border membrane enterocytes. Although otherwise phenotypically normal, NPC1L1-deficient mice exhibit substantial reduction absorbed cholesterol, which...
Short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, are metabolites formed by gut microbiota from complex dietary carbohydrates. Butyrate acetate were reported to protect against diet-induced obesity without causing hypophagia, while propionate was shown reduce food intake. However, the underlying mechanisms for these effects unclear. It suggested that SCFAs may regulate hormones via their endogenous receptors Free acid 2 (FFAR2) 3 (FFAR3), but direct evidence is...
Niemann-Pick C1 Like 1 (NPC1L1) is a protein localized in jejunal enterocytes that critical for intestinal cholesterol absorption. The uptake of phytosterols and into absorptive the intestine not fully defined on molecular level, role NPC1L1 maintaining whole body homeostasis known. null mice had substantially reduced sitosterol, with dramatically plasma phytosterol levels. were completely resistant to diet-induced hypercholesterolemia, lipoprotein hepatic profiles similar those wild type...
Background . Accumulative evidence showed that gut microbiota was important in regulating the development of nonalcoholic fatty liver disease (NAFLD). Hugan Qingzhi tablet (HQT), a lipid‐lowering and anti‐inflammatory medicinal formula, has been used to prevent treat NAFLD. However, its mechanism action is unknown. The aim this study confirm whether HQT reversed dysbiosis NAFLD rats. Methods We established an model rats fed with high‐fat diet (HFD), which given different interventions,...
Abstract Background Endoplasmic reticulum (ER) stress, promoting lipid metabolism disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Hugan Qingzhi tablets (HQT) has a definite effect in clinical treatment NAFLD patients, but its mechanism is still unclear. This study aims investigate effects HQT on ER stress tissues rats explore underlying mechanism. Methods The rat model was managed with high-fat diet (HFD) for 12weeks....
Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic disorders including hepatic lipid accumulation and inflammation. Alisol A 24-acetate, a triterpene from Alismatis rhizome, has multiple biologic activities such as hypolipidemic, anti-inflammatory anti-diabetic. Thus we hypothesized that 24 -acetate would have effect on NAFLD. The present study was conducted to investigate the therapeutic effects potential mechanisms of 24-acetate against steatosis in free acids...
A molecular model of the human melanin-concentrating hormone (MCH) peptide was constructed and docked into a helical, bacteriorhodopsin-based recently identified MCH receptor. From this hormone-receptor complex, potential sites agonist-receptor interaction were identified, site-directed mutagenesis used to substitute residues predicted reside within receptor binding pocket. Substitution Asp<sup>123</sup>(3.32) in third transmembrane domain resulted loss detectable <sup>125</sup>I-MCH...
Abstract: The recently identified 17‐amino acid peptide nociceptin (orphanin FQ) is the endogenous ligand for opioid receptor‐like‐1 (ORL‐1) receptor. A physiologic role (OFQ) activation of ORL‐1 receptor (OFQR) may be to modulate opioid‐induced analgesia. molecular mechanism by which and modify opioid‐stimulated effects, however, unclear. Both receptors mediate pertussis toxin (PTX)‐sensitive signal transduction, indicating these are capable coupling G i /G o proteins. This study determines...
Ezetimibe is the first in class 2-azetidinone that decreases plasma cholesterol by blocking intestinal absorption. effectively reduces several species including human, monkey, dog, hamster, rat, and mouse, but potency ranges widely. One potential factor responsible for this variation responsiveness diversity ezetimibe metabolism. After oral administration, glucuronidated. Both glucuronide lower cholesterol; however, exhibits greater potency. Recent identification of Niemann-Pick C1 Like-1...
Ethnopharmacological Relevance. The Hugan Qingzhi tablet (HQT) is a traditional Chinese medicine used for treating NAFLD (nonalcoholic fatty liver disease). present study evaluated the anti-inflammatory effects of HQT in rats with NAFLD. Materials and Methods. was administered daily to experimental groups. Biochemical markers, histopathological data, oxidative stress/antioxidant biomarkers were determined. Proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α),...
Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic target for treatment of obesity and related metabolic diseases. However, the degree DGAT1 inhibition required benefits unclear. Here we show that partial deficiency in mice suppressed postprandial triglyceridemia, led to elevations glucagon-like peptide-1 (GLP-1) peptide YY (PYY) only following meals with very high lipid content, did not protect from diet-induced obesity. Maximal enhanced GLP-1 PYY secretion physiologically...
In previous research, Hugan Qingzhi, a traditional Chinese medicine, was shown to have protective effects against hepatic steatosis. However, its activity nonalcoholic fatty liver disease (NAFLD) and the mechanisms by which it exerts remain unknown. present study, of Qingzhi on free acid-induced L02 cells were examined. The techniques iTRAQ labeling, together with strong cation exchange-non-liquid chromatography–tandem mass spectrometry (SCX-non-LC-MS/MS) analysis serum pharmacology, used...
Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor-based incretin therapy intended for the treatment of type 2 diabetes mellitus (T2DM), has not been linked to adverse effects on pancreas in prospective clinical trials or nonclinical toxicology studies. To further assess potential pancreatic effects, sitagliptin was studied male Zucker diabetic fatty (ZDF) rat model T2DM. Following 3 months oral dosing with vehicle, at doses 3- 19-fold above clinically therapeutic plasma concentration,...
Domestic sewage discharged into lakes brings great pressure to the ecological environment. This study selected sediment from an inland lake as a research object evaluate pollution of Eight sterols were used content pollutants, while ratios index analyze sources pollution. The correlations analyzed between and total organic carbon (TOC), salinity particle size. distribution composition sterol compounds determined in 12 surface samples collected Ulungur lake. concentrations detected sediments...
Abstract Background Previous studies have found that Hugan Qingzhi tablet (HQT) has significant lipid-lowering and antioxidant effects on non-alcoholic fatty liver disease (NAFLD). Moreover, the results of proteomic analysis confirmed various proteins in endoplasmic reticulum stress (ERS) pathway were activated recovered by HQT. However, its mechanism remains confused. The purpose this study was to explore HQT-medicated serum hepatic ERS relevant mechanisms. Methods L02 cells induced Free...
The CAR-T platform has provided an exceptionally potent means to treat cancers that have proven resistant standard treatments. This potency, however, can work against normal tissue as well. Some clinical trials identified adverse consequences a result of cell targeting critical tissue. To enable many targets possible using the approach, it is important understand potential liabilities those in tissues prior initiating trials. CD123, IL-3 receptor alpha subunit, viable target for treatment...
Abstract Background Infantile haemangiomas (IHs) involving the lip are of special concern because susceptibility complications, including ulceration, obstruction and disfigurement. The available data for relationship between their clinical characteristics ulcerations limited. Objectives To describe IHs to evaluate main risk factors ulceration. Methods A retrospective study was designed that included infants with during an 8‐year period, participants were collected, univariable multivariable...
Protein tyrosine kinases (PTKs) have been implicated in signal transduction a variety of cell types. B lymphocytes express the genes encoding for eight members src family nonreceptor PTKs. Four these PTKs (p55hlk, p53/56lyn, p59lyn, and p56lck) are activated by ligation mIg receptors. The functional roles membrane-bound immunoglobulins (mIg) receptor-mediated activation resting were examined using PTK inhibitor, herbimycin A. Here we show that B-cell proliferation differentiation inhibited...