A5029417524- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Thermography and Photoacoustic Techniques
- Optical Imaging and Spectroscopy Techniques
- Ultrasound and Hyperthermia Applications
- Extracellular vesicles in disease
- Luminescence and Fluorescent Materials
- Optical Coherence Tomography Applications
- Photodynamic Therapy Research Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Nanomaterials in Catalysis
- Thermal Regulation in Medicine
- Ultrasound Imaging and Elastography
- Microfluidic and Bio-sensing Technologies
- Advanced Chemical Sensor Technologies
- Ultrasonics and Acoustic Wave Propagation
- Electrowetting and Microfluidic Technologies
- Image Enhancement Techniques
- Asphalt Pavement Performance Evaluation
- Thermoregulation and physiological responses
- Advanced X-ray and CT Imaging
- Microwave Imaging and Scattering Analysis
- Flow Measurement and Analysis
- Infrared Thermography in Medicine
- Micro and Nano Robotics
Southern University of Science and Technology
2018-2025
Hubei University of Technology
2023-2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
Creative Commons
2024
Shenzhen Bay Laboratory
2022-2023
Innovation Team (China)
2023
Anhui Science and Technology University
2023
Anhui University of Science and Technology
2023
Sinopec Research Institute of Petroleum Processing
2022-2023
Abstract Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, optimum use dissipated energy through both radiative nonradiative pathways is definitely appealing, yet a significantly challenging task. To best knowledge, there have been no previous reports on single molecular species effective at affording all phototheranostic modalities including fluorescence (FLI), photoacoustic (PAI), photothermal (PTI),...
Here, we describe a fluorination strategy for semiconducting polymers the development of highly bright second near-infrared region (NIR-II) probes. Tetrafluorination yielded fluorescence QY 3.2 % polymer dots (Pdots), over 3-fold enhancement compared to non-fluorinated counterparts. The was attributable nanoscale fluorous effect in Pdots that maintained molecular planarity and minimized structure distortion between excited state ground state, thus reducing nonradiative relaxations. By...
A broadband low-profile circular-polarized (CP) antenna on an artificial magnetic conductor (AMC) reflector is proposed in this letter. The basic wideband circular polarization radiation characteristic of the achieved by feeding crossed dipole through a 90° phase shifter. An AMC further introduced to realize CP antenna. impedance bandwidth (VSWR <; 2) present about 1.19-2.37 GHz (66.3%), and axial-ratio (AR) (AR 3 dB) 1.25-1.97 (44.7%). has low profile 20.1 mm (about 0.12 λ <sub...
Optical resolution photoacoustic microscopy (ORPAM) represents one of the fastest evolving optical microscopic techniques. However, due to bulky size and complicated system configuration conventional ORPAM, it is largely limited small animal experiments. In this Letter, we present design evaluation a portable ORPAM with high spatiotemporal large field view. system, utilize rotatory scanning mechanism instead raster achieve translationless imaging probe/samples, making accessible human oral...
A single-component multimodal theranostic platform that takes advantage of multiple imaging and therapy techniques may offer improved diagnostic monitoring capabilities therapeutic efficacies. In this study, through structural tuning, a novel agent (TSSAM) with aggregation-induced emission (AIE) characteristics, bright second near-infrared (NIR-II) emission, high reactive oxygen species (ROS) generation capability, excellent photothermal conversion efficiency (40.1%) was developed. TSSAM...
Abstract It is generally considered that photoacoustic imaging (PAI) and fluorescence (FLI) cannot be enhanced concurrently, as they are dependent on competitive photophysical processes at the single‐molecule level. Herein, we reveal BDTR9‐OC8 BDTR9‐C8 , which have identical π‐conjugated backbones but substituted by side chains of different rigidity, show distinct phototheranostic properties in aggregated state. The NIR‐II FLI PAI brightness nanoparticles 4.6 1.4 times compared with...
The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing its rich optical contrast high resolution single modality. Here we report microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, demonstrate ability accurately map tumors three-dimension inspect the completeness tumor resection during surgery...
Purpose : The authors present the design and evaluation of a second‐generation (G2) hybrid photoacoustic tomography (PAT) diffuse optical (DOT) imaging system for detection breast cancer. combined PAT/DOT takes full advantages two different modalities to provide complementary information most accurate recovery tissue properties. Methods This was designed produce cross‐section images with ring‐shaped home‐made array 64 wideband acoustic transducers an 16/16 source/detector fiber bundles. A...
Optical resolution photoacoustic microscopy (ORPAM), benefiting from rich optical contrast, scalable acoustic resolution, and deep penetration depth, is of great importance for the fields biology medicine. However, limited by size performance reported optical/acoustic scanners, existing portable/handheld ORPAMs are bulky heavy, suffer low imaging quality/speed. Here, we present an ultracompact ORPAM probe, which miniature light, has high quality. The probe only weighs 20 grams outer 22 mm×30...
In this study, we evaluate the penetration capability of light in visible, near-infrared-I (NIR-I) and near-infrared–II (NIR-II) optical windows for photoacoustic macroscale imaging inside 9 biological tissues with three typical depths. An acoustic resolution microscopy is designed to guarantee consistent experiment conditions except excitation wavelength. Experimental results show that short NIR-II (1000-1150 nm) shows best performance kidney, spleen liver at all depths, while NIR-I...
We present a noninvasive method of photoacoustic tomography (PAT) for imaging cerebral hemodynamics in awake-moving rats. The wearable PAT (wPAT) system has size 15 mm height and 33 diameter, weight ~8 g (excluding cabling). wPAT achieved an rate 3.33 frames/s with lateral resolution 243 μm. Animal experiments were designed to show feasibility on animals. Results showed that the oxy-hemoglobin deoxy-hemoglobin changed significantly response hyperoxia; and, after injection pentylenetetrazol...
Purpose: To evaluate the feasibility of functional photoacoustic tomography (fPAT) for high resolution detection and characterization breast cancer to demonstrate first time quantitative hemoglobin concentration oxygen saturation images breasts that were formed with model‐based reconstruction tomographic data. Methods: The study was HIPAA compliant approved by university institutional review board. Written informed consents obtained from all participants. Ten cases, including six four...
We present a method for noninvasively imaging the hand joints using three-dimensional (3D) photoacoustic (PAI) system. This 3D PAI system utilizes cylindrical scanning in data collection and virtual-detector concept image reconstruction. The maximum lateral axial resolutions of are 70 μm 240 μm. cross-sectional images healthy joint clearly exhibited major internal structures including phalanx tendons, which not available from current methods. vivo results obtained comparable with...
In this Letter, we present a high-resolution photoacoustic endomicroscopy probe based on microelectromechanical systems (MEMS) scanning mirror. The built-in optical assembly consists of 0.7 mm graded-index (GRIN) lens for light focusing and ϕ1 MEMS mirror to reflect scan the beam. A miniaturized unfocused ultrasound transducer with center frequency 10 MHz is used detection. Sharp blades, carbon fibers, black tapes were utilized evaluate performance system. vivo mouse ears resected rectums...
Biohybrid micro/nanorobots have demonstrated improved therapeutic outcomes for targeting and treating diseases in preclinical trials. However, vivo applications remain challenging due to a lack of sufficient targeting. Based on evidence that immune cells play role the modulation tumor microenvironment, we developed M1 macrophage membrane-coated magnetic photothermal nanocomplexes (MPN) photoacoustic (PA) imaging-guided therapy. The MPN were able inherit protein from original exert targeted...
Fluorescence imaging in the second near-infrared (NIR-II) window has attracted considerable interest investigations of vascular structure and angiogenesis, providing valuable information for precise diagnosis early stage diseases. However, it remains challenging to image small blood vessels deep tissues because strong photon scattering low fluorescence brightness fluorophores. Here, we describe our combined efforts both fluorescent probe design algorithm development high-contrast turbid such...
Glioblastoma multiforme (GBM) is a highly invasive and fatal brain tumor with grim prognosis, where current treatment modalities, including postoperative radiotherapy temozolomide chemotherapy, yield median survival of only 15 months. The challenges heterogeneity, drug resistance, the blood–brain barrier necessitate innovative therapeutic approaches. This study introduces strategy employing biomimetic magnetic nanorobots encapsulated hybrid membranes derived from platelets M1 macrophages to...