A5058299627- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Bone Tissue Engineering Materials
- Neurotransmitter Receptor Influence on Behavior
- Lysosomal Storage Disorders Research
- Sleep and Wakefulness Research
- Graphene and Nanomaterials Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Landslides and related hazards
- Glycogen Storage Diseases and Myoclonus
- Nanoparticle-Based Drug Delivery
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Pain Mechanisms and Treatments
- Microbial Natural Products and Biosynthesis
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Parkinson's Disease Mechanisms and Treatments
- Forensic Toxicology and Drug Analysis
- Neuroendocrine regulation and behavior
- Intracerebral and Subarachnoid Hemorrhage Research
- Optical Imaging and Spectroscopy Techniques
- Mesenchymal stem cell research
- Thermoregulation and physiological responses
- Rock Mechanics and Modeling
East China University of Science and Technology
2013-2025
Ningxia Medical University
2025
University of Georgia
2022-2025
Guangxi Medical University
2025
Beijing Anding Hospital
2025
Sichuan University
2015-2024
West China Hospital of Sichuan University
2015-2024
Ministry of Water Resources of the People's Republic of China
2024
China Institute of Geological Environmental Monitoring
2020-2024
Laboratoire Traitement et Communication de l’Information
2024
Abstract Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric adult patients, respectively. Both exhibit significant heterogeneity, shaped by distinct genetic/epigenetic drivers, transcriptional programs including RNA splicing, microenvironmental cues glioma niches. However, spatial organization of cellular states niche-specific regulatory remain to be investigated. Here, we perform a profiling DMG GBM combining...
Abstract Articular cartilage defects bring about disability and worldwide socioeconomic loss, therefore, articular repair regeneration is recognized as a global issue. However, due to its avascular nearly acellular characteristic, tissue ability limited some extent. Despite the availability of various treatment methods, including palliative drugs surgical regenerative therapy, still face major challenges lack appropriate methods materials. Smart biomaterials can regulate cell behavior...
Background: Silica nanoparticles have been discovered to exert cytotoxicity and induce apoptosis in normal human cells. However, until now, few studies investigated the of silica tumor Methods: This study 7–50 nm HepG2 hepatoma cells, using L-02 hepatocytes as a control. Cell nucleus morphology changes, cellular uptake, expression procaspase-9, p53, Bcl-2, Bax, well activity caspase-3, intracellular reactive oxygen species glutathione levels nanoparticle-treated were analyzed. Results: The...
Bone morphogenetic protein-2 (BMP-2) is considered one of the most effective and extensively used growth factors to induce osteoblast differentiation accelerate bone regeneration. Dexamethasone (Dex) with suitable dosage can enhance BMP-2-induced differentiation. To strengthen this synergistic osteoinductive effect, a pH-responsive chitosan-functionalized mesoporous silica nanoparticle (chi-MSN) ensemble was fabricated for dual-delivery BMP-2 Dex. The MSNs are prepared by CTAB-templated...
For cases of severe traumatic brain injury, during primary operation, neurosurgeons usually face a dilemma whether or not to remove the bone flap after mass lesion evacuation. Decompressive craniectomy, which involves expansion fixed cranial cavity, is used treat intra-operative swelling and post-operative malignant intracranial hypertension. However, due indefinite indication, decision perform this procedure heavily relies on personal experiences. In addition, decompressive craniectomy...
Immune checkpoint blockade (ICB) therapy, including antibodies targeting the programmed cell death protein 1 (PD-1) pathway, has significantly prolonged overall survival (OS) in patients with advanced cervical cancer (CC). ICB treatment affects both target cells and various components released by immune cells, which can be observed peripheral blood. However, there been limited research on dynamics of blood immunophenotyping its association OS CC receiving therapy. Patients persistent,...
Background The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences injections 3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic metabolite dopamine, into substantia nigra rats on motor behavior and neuronal survival. Methods/Principal Findings A total 800 nl/rat DOPAL (1 µg/200 nl) was injected stereotaxically over three sites while control animals received similar phosphate buffered saline. Rotational these analyzed, optical density striatal...
In this study, we evaluate the penetration capability of light in visible, near-infrared-I (NIR-I) and near-infrared–II (NIR-II) optical windows for photoacoustic macroscale imaging inside 9 biological tissues with three typical depths. An acoustic resolution microscopy is designed to guarantee consistent experiment conditions except excitation wavelength. Experimental results show that short NIR-II (1000-1150 nm) shows best performance kidney, spleen liver at all depths, while NIR-I...
Polylactic acid (PLA) has been extensively researched in biomedical engineering applications due to its superior mechanical strength and biocompatibility <italic>in vivo</italic>.
Endosomal pH-driven linkage-disintegration is a promising strategy to achieve intracellular delivery and controlled drug release. In this paper, rapid endosomal pH-sensitive MSNs ensemble (i.e., MCM-TAA-Fe3O4) with magnetic nanoparticle caps was developed by anchoring superparamagnetic Fe3O4 nanoparticles on the pore openings an acid-labile substituted 1,3,5-triazaadamantane (TAA) group. The functionalized served as nanogate regulate release pattern and/or dosage of payload. in vitro...
Abstract Background Inflammatory bowel disease (IBD), which includes Crohn’s (CD) and ulcerative colitis (UC), is a long-term condition characterized by inflammation of the gut. Research has shown that disruption gut microbiota, known as dysbiosis, plays an important role in disease. While current treatments focus on controlling inflammation, many patients continue to experience symptoms or side effects. This study explores effectiveness new therapy aimed at restoring balance microbes...
By combining protein engineering and synthetic biology strategies, the novel de novo biosynthesis of 4,6-dihydroxycoumarin from glycerol was realized in Escherichia coli for first time.
ABSTRACT Escherichia coli accumulates acetate as a byproduct in fast growth aerobic conditions when using glucose carbon source. This phenomenon, known overflow metabolism, has negative impacts on cell and protein expression, also causes loss during biosynthesis most microbial production scenarios. In this study, we regarded the “waste” metabolite useful metabolism indicator, constructed an biosensor to monitor change of concentration converted signal into various regulation outputs....
To investigate the risk factors for rebleeding in patients with IIb peptic ulcer bleeding (PUB) treated endoscopically and to develop a nomogram model. A retrospective analysis was conducted on 287 grade PUB who underwent endoscopic treatment at Beijing Pinggu Hospital from January 2019 December 2023. The were divided into modelling cohort (n=201) validation (n=86) 7:3 ratio. consisted of non-bleeding (NB) group (n=176) re-bleeding (RB) (n=25), while included an NB (n=75) RB (n=11). Logistic...
Underwater submersion in mammals induces apnea, parasympathetically mediated bradycardia, and sympathetically peripheral vasoconstriction. These effects are collectively termed the diving response, potentially most powerful autonomic reflex known. Although these physiological responses directed by neurons brain, study of neural control response has been hampered since 1) it is difficult to brains animals while they underwater, 2) feral marine usually large have variable size, 3) there but...