A5101899031- Selenium in Biological Systems
- Trace Elements in Health
- GaN-based semiconductor devices and materials
- HIV Research and Treatment
- Microbial Community Ecology and Physiology
- Lung Cancer Diagnosis and Treatment
- Heavy Metal Exposure and Toxicity
- Chemical Synthesis and Reactions
- Semiconductor materials and devices
- Neurological Disease Mechanisms and Treatments
- Asymmetric Hydrogenation and Catalysis
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Birth, Development, and Health
- Protist diversity and phylogeny
- Medicinal Plant Pharmacodynamics Research
- COVID-19 and Mental Health
- Medical Imaging Techniques and Applications
- Ultrasound in Clinical Applications
- Liver physiology and pathology
- Wnt/β-catenin signaling in development and cancer
- Advanced Measurement and Detection Methods
- Flavonoids in Medical Research
- Communication in Education and Healthcare
- Ferroelectric and Negative Capacitance Devices
Southwest University
2024
Fordham University
2024
First Affiliated Hospital of Chengdu Medical College
2024
Shenzhen Institutes of Advanced Technology
2021-2023
Chinese Academy of Sciences
2014-2023
Nankai University
2022-2023
University of Chinese Academy of Sciences
2014-2023
Dongyang People's Hospital
2023
Wenzhou Medical University
2023
Bohai University
2022
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopamine (DA) neurons in midbrain substantia nigra pars compacta (SNpc). While existing therapeutic strategies can alleviate PD symptoms, they cannot inhibit DA neuron loss. Herein, tailor-made human serum albumin (HSA)-based selenium nanosystem (HSA/Se nanoparticles, HSA/Se NPs) to treat that overcome intestinal epithelial barrier (IEB) and blood-brain (BBB) described. HSA, transporter for drug...
The blood-brain barrier (BBB) is primarily manifested by a variety of physiological properties brain endothelial cells (ECs), but the molecular foundation for these remains incompletely clear. Here, we generate comprehensive atlas adult ECs using acutely purified mouse and integrated multi-omics. Using RNA sequencing (RNA-seq) proteomics, identify transcripts proteins selectively enriched in demonstrate that they are partially correlated. single-cell RNA-seq, dissect basis functional...
Abstract The investigation of the thermal stability and evolution Pd-Au core-shell nanostructures across various temperatures proceeded with in situ heating transmission electron microscopy (TEM) along spectral analysis techniques. In was utilized to examine morphology elemental distribution composed Pd 0.5 -Au 0.9 0.1 , which were synthesized via seed growth technique. Compared nanostructures, have better stability.
Abstract Ferroelectric field-effect transistors, characterized by low operating voltages and ultra-high speeds, are an important non-volatile memory device concept in modern microelectronics. Here, we show ferroelectric transistors using CuInP 2 S 6 as the layer MoS semiconductor channel layer. Thanks to optimized material thicknesses clean, trap-free interfaces, have achieved high-performance with voltage 1.5 V ultrafast speed of 20 ns. Our devices a large on/off ratio about 10 window 1.7...
Background Despite recent advances in human immunodeficiency virus-1 (HIV-1) prevention, a fast, safe, and effective vaccine will probably be necessary to end the HIV/AIDS pandemic. This study was conducted evaluate global research trends map key bibliometric indices HIV-1 genetic diversity from 1998 2021.Methods A comprehensive online search Web of Science Core Collection database retrieve published literature on diversity. Key indicators were calculated evaluated using HistCiteTM,...
Membrane viscosity is an important property of cell biology, which determines cellular function, development and disease progression. Various experimental computational methods have been developed to investigate the mechanics cells. However, there no measurements membrane at high-frequencies in live High frequency are because they can probe viscoelastic effects. Here, we gigahertz-frequencies through damping acoustic vibrations gold nanoplates. The experiments modeled using a continuum...
This study aimed to evaluate the value of low-dose dual-input computed tomography perfusion (CTP) imaging in differential diagnosis benign and malignant pulmonary ground-glass opacity nodules (GGO). A retrospective was conducted patients with GGO who underwent CTP our hospital from January 2021 October 2023. All were confirmed via pathological analysis or disappeared during follow-up. Postprocessing using mode (pulmonary artery bronchial artery) body software measure parameters GGOs. total...
In this paper, the trap behaviours in AlGaN/GaN high electron mobility transistors (HEMTs) are investigated using transient capacitance measurement. By measuring gate variance (ΔC) with different pulse height, induced SiNX dielectric layer or at SiNX/AlGaN interface is revealed. Based on results, a model traps HEMTs proposed. The threshold voltage (Vth) instability believed to be correlated presence of these interface. Furthermore, density before and after step-stress applied drain electrode...
In addition to the unprecedented challenges and stressors that university students faced during COVID-19 pandemic, Asian American experienced specific hardships due COVID-19-associated xenophobic attitudes, harassment, assault against people of complexions. This qualitative study aimed explore ways in which students’ experiences pandemic changed their views identities as Americans by analyzing in-depth interviews four case participants. Secondary analysis two waves interviews, were conducted...
<title>Abstract</title> This study aimed to evaluate the value of low-dose dual-input targeted perfusion computed tomography (CT) imaging in differential diagnosis benign and malignant pulmonary ground-glass opacity nodules (GGOs).A prospective was conducted patients with GGOs who underwent CT from January 2022 October 2023. All were confirmed by pathological analysis or disappeared during follow-up. The mode (pulmonary artery bronchial artery) body software used for postprocessing measure...
HIV-1 infection is mediated by a viral envelope subsequently binding to CD4 receptor and two main coreceptors, CCR5 (R5) for primary CXCR4 (X4) in chronic infection. Switching from R5 X4 tropism associated with increased pathogenesis disease progression. The coreceptor switching mainly due variations the V3 loop, while mechanism needs be further elucidated. We systematically studied determinant substitution of genes one pseudoviruses. study results successfully constructing panels chimeric...
Abstract Oxidative stress induces apoptosis in cardiac cells, and antioxidants attenuate the injury. MicroRNAs (miRNAs) are also involved cell death; therefore, this study aimed to investigate role of miRNAs effect selenium on oxidative stress‐induced apoptosis. The effects sodium selenite were analyzed via viability, superoxide dismutase (SOD) activity, malondialdehyde (MDA) concentration. Flow cytometry was used evaluate Fura‐2AM calculate intracellular Ca 2+ Sodium could ameliorate...
A chiral Lewis base organocatalyzed asymmetric hydrosilylation of α-substituted β-enamino esters is presented. The reactions proceeded through dynamic kinetic resolution to afford various enantioenriched β<sup>2</sup>-amino with high yields (up 98%) in moderate enantioselectivities 77% ee).
Transfer RNA selenocysteine 1 associated protein (Trnau1ap) serves an essential role in the synthesis of selenoproteins, which have critical functions numerous biological processes. Selenium deficiency results a variety diseases, including cardiac disease. However, mechanisms underlying myocardial injury induced by selenium remain unclear. The present study examined effects Trnau1ap under‑ and overexpression cardiomyocyte‑like H9c2 cells, transfection with small interfering plasmid,...
Up to now, the chemotherapy approaches for glioblastoma were limited. 1-[2-Thiazolylazo]-2-naphthol (named as NSC139021) was shown significantly inhibit proliferation of prostate cancer cells by targeting atypical protein kinase RIOK2. It is documented that RIOK2 overexpressed in glioblastoma. However, whether NSC139021 can growth and be a potential drug treatment need clarified. In this study, we investigated effects on human U118MG, LN-18, mouse GL261 models We verified effectively...