A5100634512- Selenium in Biological Systems
- Trace Elements in Health
- Birth, Development, and Health
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- MicroRNA in disease regulation
- Virology and Viral Diseases
- Heavy Metal Exposure and Toxicity
- RNA Research and Splicing
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- RNA regulation and disease
- Systemic Lupus Erythematosus Research
- Garlic and Onion Studies
- Ferroptosis and cancer prognosis
- Inflammatory Bowel Disease
- Microscopic Colitis
- Cancer-related Molecular Pathways
- Vitamin D Research Studies
- Organ Transplantation Techniques and Outcomes
- Quality Function Deployment in Product Design
- Vitamin C and Antioxidants Research
- Parvovirus B19 Infection Studies
Harbin Medical University
2012-2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Hunan University
2022-2024
Education Department of Heilongjiang Province
2010
Second Affiliated Hospital of Harbin Medical University
2009
Cancer stem cells (CSCs), characterized by self-renewal and unlimited proliferation, lead to therapeutic resistance in lung cancer. In this study, we aimed investigate the expressions of cell-related genes adenocarcinoma (LUAD). The stemness index based on mRNA expression (mRNAsi) was utilized analyze LUAD cases Genome Atlas (TCGA). First, mRNAsi analyzed with differential expressions, survival analysis, clinical stages, gender LUADs. Then, weighted gene co-expression network analysis...
The aim of this study was to analyze the changes in complements C3 and C4 C-reactive protein (CRP) patients with systemic lupus erythematosus (SLE) rheumatoid arthritis (RA), evaluate role these indices differential diagnosis SLE RA. first 347 SLE, 382 RA 66 erythema nodosum were selected for measurement complement CRP levels serum, control group. roles disease activity evaluation analyzed SPSS 13.0. Complement significantly reduced compared those However, patients, level increased. In...
Background MicroRNAs (miRNAs) participate in the regulation of cardiac hypertrophy. However, it remains largely unknown as to how miRNAs are integrated into hypertrophic program. Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is a signaling marker. It not yet clear which can regulate CaMKIIδ. Purpose In this study, we identified could CaMKIIδ and Methods Through computational expression analyses, miR-30b-5p was candidate regulator Quantitative analysis models demonstrated significant...
Increasing evidence suggests that the glutathione peroxidase 2 may actually play important roles in tumorigenesis and progression various human cancers such as colorectal carcinomas lung adenocarcinomas. However, role of gastric carcinoma remains to be determined. In this study, expression prognostic significance were investigated well-known factor Ki-67 labeling index was also assessed positive control. Glutathione levels tumor tissue specimens, matched adjacent normal lymph node metastases...
Breast cancer patients at the same stage may show different clinical prognoses or therapeutic effects of systemic therapy. Differentially expressed genes breast were identified from GSE42568. Through survival, receiver operating characteristic (ROC) curve, random forest, GSVA and a Cox regression model analyses, that could be associated with survival time in cancer. The molecular mechanism was by enrichment, GSEA, methylation SNV analyses. Then, expression key gene verified TCGA dataset...
S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane. However, stemness genes modulated ZDHHCs in lung adenocarcinoma (LUAD) remain to be defined. Previously, we have constructed network cancer stem genes, including INCENP, based mRNA indices (mRNAsi) LUAD. INCENP has function chromosomal passenger complex locating centromeres, which is performed conserved region its N-terminal...
Gemcitabine (GEM)-based chemotherapy is the standard regimen for treatment of pancreatic cancer (PC). However, chemoresistance a major challenge in PC treatment. Reliable biomarkers are urgently needed to predict response GEM-based therapies. GEM-sensitive (GEM-S) and GEM-resistant (GEM-R) carcinoma xenograft models were established, GEM monotherapy plus nanoparticle albumin-bound paclitaxel (nab-PTX) doublet therapy administered GEM-S/R tumor-bearing mice. Metabolomic mass spectrometry (MS)...
Abstract Objective This study aimed to estimate the incidence rate and clinical characteristics of inflammatory bowel disease (IBD) in Chinese population, specially comparing North South regions. Methods We designed a questionnaire survey for patients diagnosed with IBD conducted systematic literature search PubMed, China National Knowledge Internet, Wanfang digital database, covering studies published between 2012 2022. Meta-analysis was performed determine overall prevalence manifestations...
Abstract Oxidative stress induces apoptosis in cardiac cells, and antioxidants attenuate the injury. MicroRNAs (miRNAs) are also involved cell death; therefore, this study aimed to investigate role of miRNAs effect selenium on oxidative stress‐induced apoptosis. The effects sodium selenite were analyzed via viability, superoxide dismutase (SOD) activity, malondialdehyde (MDA) concentration. Flow cytometry was used evaluate Fura‐2AM calculate intracellular Ca 2+ Sodium could ameliorate...