A5100765492- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Plant tissue culture and regeneration
- Insect and Pesticide Research
- Plant Molecular Biology Research
- Gallbladder and Bile Duct Disorders
- Autophagy in Disease and Therapy
- Plant and animal studies
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Insect and Arachnid Ecology and Behavior
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Plant Reproductive Biology
- Pancreatitis Pathology and Treatment
Yangtze University
2021-2025
Southern Medical University
2024-2025
Nantong University
2025
Sun Yat-sen University
2014-2024
Sun Yat-sen University Cancer Center
2014-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Beijing Radiation Center
2021-2024
Eastern Hepatobiliary Surgery Hospital
2024
Second Military Medical University
2024
First Affiliated Hospital Zhejiang University
2024
Abstract Background Pancreatic cancer is one of the most lethal malignancies and has an extremely poor diagnosis prognosis. The development resistance to gemcitabine still a major challenge. long noncoding RNA PVT1 was reported be involved in carcinogenesis chemoresistance; however, mechanism by which regulates sensitivity pancreatic remains poorly understood. Methods viability cells assessed MTT assay vitro xenograft tumor formation vivo. expression levels miR-619-5p were detected...
Abstract The rapid generation of various species and strains laboratory animals using CRISPR/Cas9 technology has dramatically accelerated the interrogation gene function in vivo . So far, dominant approach for genotyping genome-modified been T7E1 endonuclease cleavage assay. Here, we present a polyacrylamide gel electrophoresis-based (PAGE) method to genotype mice harboring different types indel mutations. We developed 6 system utilized this from F0 F2 generation, which included single...
A better understanding of the molecular mechanism involving lncRNA-miRNA-mRNA network underlying glioma genesis is beneficial to treatment glioma. This study was designed investigate role lncRNA NEAT1, miR-132 and SOX2 interaction in glioma.Microarray analysis conducted identify differentially expressed lncRNAs tissues. The expression levels were determined by qRT-PCR western blot. Proliferation cells detected MTT assay, while migration invasion transwell assay. target relationships...
Portal vein tumor thrombus (PVTT) is very common and it plays a major role in the prognosis clinical staging of hepatocellular carcinoma (HCC). We have published first version guideline 2016 revised 2018. Over past several years, many new evidences for treatment PVTT become available, especially advent targeted drugs immune checkpoint inhibitors which further improved PVTT. So, Chinese Association Liver Cancer Medical Doctor 2018 to adapt development treatment. Future strategies HCC with...
Abstract Background As the gatekeepers of rural residents’ health, teams village doctors play a vital role in improving health. However, high turnover doctors, both individually and collectively, threaten stability medical teams. This research evaluated influence job satisfaction, resilience, work engagement on doctors’ intention, explored mediating resilience between satisfaction intention China. Methods A quantitative study using self-administered questionnaire containing mostly structured...
Background Currently, the prevalence of allergic rhinitis (AR) remains high and there is a great need to develop better safer ways alleviate AR symptoms. The Lactobacillus plantarum GUANKE probiotic was reported as an immunomodulator through maintaining Th1/Th2 balance. This study aimed determine efficacy in subjects. Methods Adults aged from 18 60 years old previously suffered were recruited received probiotics treatment for 4 weeks. questionnaires Total nasal symptom scores (TNSS), total...
ABSTRACT In order to achieve energy‐saving in fast freezing equipment, it is necessary understand the factors that affect food time. A fluid structure coupling model was established for process of beef a room. total 45 simulation areas were set with 9 racks and 5 chunks on each rack. model, specific heat capacity packages defined as function temperature. The core temperatures frozen load instead real measured verify correctness model. airflow velocity, air temperature product simulated at...
A new computed tomography (CT) imaging agent is developed based on the BODIPY-containing nanoscale metal–organic frameworks (NMOFs). The bio-safety and CT of such NMOFs have been well investigated both <italic>in vitro</italic> vivo</italic>.
The tumor cells have some metabolic characteristics of the original tissues, and metabolism is closely related to autophagy. However, mechanism autophagy in chemotherapeutic drug resistance still poorly understood. In this study, we investigated role glucose by using cholangiocarcinoma QBC939 with primary cisplatin hepatocellular carcinoma HepG2 cells. We found that had a higher capacity for uptake, consumption, lactic acid generation, activity pentose phosphate pathway compared cells, PPP...
Plenty of studies have confirmed the prognostic values inflammation-based scores in many malignant tumors. In present study, we aim to explore whether these indexes has same patients with stage T1N0 esophageal squamous cell carcinoma (ESCC). The clinicopathological data 160 consecutive pathological ESCC from January 2005 December 2012 were collected retrospectively. As factors, scores, including C-reactive protein (CRP), Glasgow score (GPS), index (PI), neutrophil lymphocyte ratio (NLR),...
Abstract Chayote ( Sechium edule ) is an agricultural crop in the Cucurbitaceae family that rich bioactive components. To enhance genetic research on chayote, we used Nanopore third-generation sequencing combined with Hi–C data to assemble a draft chayote genome. A chromosome-level assembly anchored 14 chromosomes (N50 contig and scaffold sizes of 8.40 46.56 Mb, respectively) estimated genome size as 606.42 which large for Cucurbitaceae, 65.94% (401.08 Mb) comprising repetitive sequences;...
Momordica charantia L. var. abbreviata Ser. (Mca), known as bitter gourd or melon, is a variety with medicinal value and belongs to the Cucurbitaceae family. In view of lack genomic information on other species promote Mca research, we assembled 295.6-Mb telomere-to-telomere (T2T) high-quality genome six gap-free chromosomes after Hi-C correction. This anchored 11 chromosomes, which consistent karyotype information, comprises 98 contigs (N50 25.4 Mb) 95 scaffolds Mb). The harbors 19 895...