A5100626069- Mollusks and Parasites Studies
- Aquaculture Nutrition and Growth
- Parasite Biology and Host Interactions
- Physiological and biochemical adaptations
- Crustacean biology and ecology
- Medical and Biological Ozone Research
- Cancer-related molecular mechanisms research
- Parasites and Host Interactions
- Parasitic Diseases Research and Treatment
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Chemical Synthesis and Reactions
- Helminth infection and control
- Bone Tissue Engineering Materials
- BRCA gene mutations in cancer
- Catalytic C–H Functionalization Methods
- Autophagy in Disease and Therapy
- Invertebrate Immune Response Mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Genetic diversity and population structure
- Reproductive biology and impacts on aquatic species
- Synthesis of Indole Derivatives
Chinese Academy of Fishery Sciences
2020-2025
Ministry of Agriculture and Rural Affairs
2022-2025
Qiqihar University
2023
Shanghai Ocean University
2020-2022
Zhejiang University of Technology
2022
Baise University
2021
Southeast University
2020
Second Affiliated Hospital of Nanjing Medical University
2020
Sun Yat-sen University
2012-2019
Second Affiliated Hospital of Guangzhou Medical University
2017
Abstract Background Pancreatic cancer is one of the most lethal malignancies and has an extremely poor diagnosis prognosis. The development resistance to gemcitabine still a major challenge. long noncoding RNA PVT1 was reported be involved in carcinogenesis chemoresistance; however, mechanism by which regulates sensitivity pancreatic remains poorly understood. Methods viability cells assessed MTT assay vitro xenograft tumor formation vivo. expression levels miR-619-5p were detected...
17α-methyltestosterone (MT) is known for its ability to suppress ovaries and induce spermatogenesis; yet, effects in crustaceans are underexplored. This study investigates the impact of varying MT concentrations on gonadal development intestinal microbiota juvenile Macrobrachium rosenbergii. Feeds containing different doses were provided, sex ratios, histological observations, reproductive gene expression, microbial composition analyzed. The results revealed short-term feeding (60 days) 1000...
Through a 30-day experiment, this study investigated the effects of five photoperiods (0L:24D, 6L:18D, 12L:12D, 18L:6D, and 24L:0D) on survival, enzyme activity, body color, growth-related gene expression redclaw crayfish (Cherax quadricarinatus) juveniles. The results showed that C. quadricarinatus juveniles under 18L:6D 24L:0D exhibited highest survival rate, which was significantly higher than rates other three (p < 0.05). However, 0L:24D group had final weight gain surpassing those...
Salinity stress can trigger a series of physiological changes. However, the mechanism underlying response to acute salinity in Macrobrachium rosenbergii remains poorly understood. In this study, osmoregulation, metabolism, antioxidant capacity, and apoptosis were examined over 96 h stress. Hemolymph osmolality increased with increasing salinity. After 48 exposure, glucose, triglycerides, total protein, cholesterol contents two groups (13 26‰ salinity) significantly lower than those 0‰ group....
Angiostrongylus cantonensis (A. cantonensis) infection can result in increased risk of eosinophilic meningitis. Accumulation eosinophils and inflammation the A. playing an important role brain tissue injury during this pathological process. However, underlying mechanisms regarding transcriptomic responses caused by are yet to be elucidated. This study is aimed at identifying some genomic factors influencing accumulation mouse infected with cantonensis. An model was prepared based on our...
Angiostrongylus cantonensis (rat lungworm) is the etiological agent of angiostrongyliasis, mainly causing eosinophilic meningitis or meningoencephalitis in human. Although biology A. relatively well known, little understood about mechanisms parasite's development and survival definitive hosts, its adaptation to a broad range snail intermediate hosts. Here, we generate high-quality assembly well-defined laboratory strain from Guangzhou, China, by using Illumina PacBio sequencing technologies....
Abstract A base‐promoted three‐component oxidative sulfuration/cyclization reaction of 2‐amino‐1,4‐naphthoquinone, aldehyde and elemental sulfur was developed. The naphtho[2,3‐d]thiazole ring determined by forming two C−S bonds one C=N bond, which demonstrates the advantages cheap raw materials, no transition metal, economic efficiency. substrate scope broad with aromatic aliphatic aldehydes. mechanistic study might promote design for a reaction.
The immune microenvironment plays an essential role in osteosarcoma (OSs); however, differences immune-related long non-coding ribonucleic acids (irlncRNAs) children with localized OSs and metastatic have not yet been investigated.The clinical data the transcriptome of were obtained from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database, genes derived imported dataset. correlations between lncRNAs examined. Next, differential expressions irlncRNA pairs...
The spectrum is a key environmental factor, and light‐emitting diodes (LEDs) can influence the growth development of crustaceans by altering composition spectrum. This study conducted 30‐day experiment to investigate effects five LED spectra (red, yellow, blue, green, white light) on growth, antioxidant immune enzyme activities, stress hormone levels, expression α ‐amylase ( α-AMY ), ecdysone receptor EcR ) retinoid X RXR genes in juvenile redclaw crayfish Cherax quadricarinatus ). results...
Angiostrongylus cantonensis invades the central nervous system (CNS) of humans to induce eosinophilic meningitis and meningoencephalitis leads persistent headache, cognitive dysfunction, ataxic gait. Infected mice (nonpermissive host), admittedly, suffer more serious pathological injuries than rats (permissive host). However, basis these manifestations is incompletely elucidated. In this study, behavioral test, histological immunohistochemical techniques, analysis apoptotic gene expression,...
Salinity is a crucial factor influencing the growth, development, immunity, and reproduction of aquatic organisms; however, little known about molecular mechanism response to salinity challenge in larvae giant freshwater prawn Macrobrachium rosenbergii . Herein, cultured three treatment groups with salinities 10, 13, 16‰ (S10, S13, S16) were collected, then transcriptome analysis was conducted by RNA-seq. A total 6,473, 3,830 3,584 differentially expressed genes (DEGs) identified S10 vs. S13...
Immunotherapy has made great strides in cancer treatment. Endometrial carcinoma (EC) been 1 of the most common tumors among women. This study aimed to screen immune-related prognosis biomarkers for EC.The transcriptome profiling and clinical data EC were downloaded from The Carcinoma Genome Atlas (TCGA) public database, differentially expressed genes (DEGs) obtained through limma package R software. An (IRGs) list was collected ImmPort database. We constructed a free-scale gene co-expression...
The moss Racomitrium canescens (R. canescens) has strong desiccation tolerance. It can remain desiccated for years and yet recover within minutes of rehydration. Understanding the responses mechanisms underlying this rapid rehydration capacity in bryophytes could identify candidate genes that improve crop drought We explored these using physiology, proteomics, transcriptomics. Label-free quantitative proteomics comparing plants samples rehydrated 1 min or 6 h suggesting damage to chromatin...
Angiostrongylus cantonensis is a parasitic nematode that needs to develop in different hosts larval stages. Freshwater snails, such as Pomacea canaliculata, are the intermediate host, and rats definitive host. Periodic shedding of cuticle (moulting) an important biological process for survival development parasite hosts. However, there few studies on alterations between stages this parasite. In study, we observed ultrastructural appearance changes 2nd/3rd stage larvae (L2/L3) 3rd/4th (L3/L4)...
The role of immune-related long noncoding RNAs (irlncRNAs) in breast cancer (BRCA) is still unclear. Recently, studies have performed analyses based on the expression irlncRNAs, however, present study, we used a novel method that did not require specific levels lncRNAs BRCA patients.We downloaded transcriptome and clinical data patients from Cancer Genome Atlas (TCGA), obtained immune genes Immport database, extracted for correlation analysis. Then, differential irlncRNA pairs (IRLPs) was...
Cherax quadricarinatus, also known as the redclaw crayfish, is native to northern Australia and southern Papua New Guinea an important freshwater aquaculture species in many countries. Studying genetic structure of current cultured population can improve breeding plan for crayfish better manage hybridization germplasm bank promote their rational utilization; however, microsatellite resources remain insufficient. The purpose this study was analyze diversity different populations China. After...
Macrobrachium rosenbergii is an important cultured shrimp worldwide, and its precocious puberty has led to serious economic losses. Although reproductive sterilization can avoid this problem, little known about the molecular mechanisms underlying gonadal development gametogenesis in M. . Here, we conducted transcriptome analysis of ovaries, testes, male/female brain tissues discover germ cell development-related genes. A total 60,607 unigenes were identified, which 20,963 could be...