A5007857117- Nicotinic Acetylcholine Receptors Study
- Smoking Behavior and Cessation
- Epigenetics and DNA Methylation
- Hepatitis C virus research
- Genetic Associations and Epidemiology
- Fluoride Effects and Removal
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- RNA modifications and cancer
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Anesthesia and Neurotoxicity Research
- Neurotransmitter Receptor Influence on Behavior
- Wnt/β-catenin signaling in development and cancer
- Liver Disease Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Allergic Rhinitis and Sensitization
- 14-3-3 protein interactions
- Acute Myeloid Leukemia Research
- COVID-19 diagnosis using AI
- Child and Adolescent Psychosocial and Emotional Development
- S100 Proteins and Annexins
- Nuclear Receptors and Signaling
- Reproductive System and Pregnancy
- Neuropeptides and Animal Physiology
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2017-2025
First Affiliated Hospital Zhejiang University
2016-2025
National Clinical Research Center for Digestive Diseases
2023-2025
Hangzhou City University
2024
Zhejiang University
2016-2023
Seton Hall University
2019
Shanxi Agricultural University
2014-2016
Nantong Science and Technology Bureau
2016
Background Currently, the prevalence of allergic rhinitis (AR) remains high and there is a great need to develop better safer ways alleviate AR symptoms. The Lactobacillus plantarum GUANKE probiotic was reported as an immunomodulator through maintaining Th1/Th2 balance. This study aimed determine efficacy in subjects. Methods Adults aged from 18 60 years old previously suffered were recruited received probiotics treatment for 4 weeks. questionnaires Total nasal symptom scores (TNSS), total...
The mesolimbic dopamine system is crucial for drug reinforcement and reward learning, leading to addiction. We previously demonstrated that Arvcf was associated significantly with nicotine alcohol addiction through genome-wide association studies. However, the role mechanisms of in dopamine-mediated processes were largely unknown. In this study, we first showed mediates nicotine-induced behavior by using conditioned place preference (CPP) model on Arvcf-knockout (Arvcf-KO) animal model....
Although it is known that there a high smoking prevalence among Chinese, key issues such as social and environmental factors impacting initiation persistence, the percentage of smokers considered nicotine dependence (ND), availability use ND treatments have rarely been investigated.To address these issues, from 2012 to 2014, we conducted large-scale study in Zhejiang Shanxi provinces China using Fagerström Test for Nicotine Dependence other validated questionnaires.Of 17,057 subjects,...
Abstract We sequenced RNA transcripts from the testicles of healthy male mice, divided into a control group with distilled water and two experimental groups 50 100 mg/l NaF in drinking for 56 days. Bowtie/Tophat were used to align 50-bp paired-end reads transcripts, Cufflinks measure relative abundance each transcript IPA analyze RNA-Sequencing data. In NaF-treated group, four pathways related IL-17, TGF-β other cellular growth factor overexpressed. The mRNA expression IL-17RA , IL-17RC...
Abstract Nicotine dependence (ND) is a worldwide health problem. Numerous genetic studies have demonstrated significant association of variants in nicotinic acetylcholine receptors (nAChRs) with smoking behaviors. However, most these enrolled only subjects European or African ancestry. In addition, although an increasing body evidence implies causal connection single-nucleotide polymorphisms (SNPs) and epigenetic regulation gene expression, few this issue been reported. study, we performed...
Abstract Backgrounds Although studies have demonstrated that the NCAM1–TTC12–ANKK1–DRD2 gene cluster plays essential roles in addictions subjects of European and African origin, study Chinese Han is limited. Further, underlying biological mechanisms detected associations are largely unknown. Methods Sixty-four single-nucleotide polymorphisms (SNPs) this were analyzed for association with Fagerstrőm Test Nicotine Dependence score (FTND) cigarettes per day (CPD) male smokers (N = 2616)....
The prevalence of smoking is significantly higher in persons with schizophrenia (SCZ) than the general population. However, biological mechanisms comorbidity and SCZ are largely unknown. This study aimed to reveal shared pathways for two diseases by analyzing data from genome-wide association studies a total sample size 153,898. With pathway-based analysis, we first discovered 18 enriched smoking, which were classified into five groups: postsynaptic density, cadherin binding, dendritic...
Elevation of the blood ethanol concentration (BEC) to > 80 mg/dL (17.4 mM) after binge drinking enhances inflammation in brain and neuroimmune signaling pathways. Morphine abuse is frequently linked excessive drinking. exerts its actions mainly via seven transmembrane G-protein-coupled mu opioid receptors (MORs). Opioid use disorders (OUDs) include combination opioids with alcohol, leading overdose-related deaths. We hypothesized that potentiates onset progression OUD. Using C57BL/6J (B6)...
Abstract Acute myeloid leukaemia (AML) is a biologically heterogeneous haematological malignancy. This study was performed to identify the potential biomarkers for prognosis and treatment of AML. We applied weighted gene co‐expression network analysis key modules hub genes related AML using data from The Cancer Genome Atlas (TCGA). In total, 1581 differentially expressed (1096 upregulated 485 downregulated) were identified between patients healthy controls, with blue module being most...
Abstract Although numerous studies have revealed significant associations between variants in the nicotinic acetylcholine receptors (nAChR) subunits and nicotine dependence (ND), only few were performed Chinese subjects. Here, we association interaction analysis for 20 single nucleotide polymorphisms (SNPs) CHRNB3-CHRNA6 gene cluster with ND a Han population (N = 5,055). We found nominally all tested SNPs measured by Fagerström Test Nicotine Dependence score; of these, 11 remained after...
Variants in serotonergic genes are implicated nicotine dependence (ND) subjects of European and African origin, but their involvement with smoking Asians is largely unknown. Moreover, mechanisms underlying the ND risk-associated single-nucleotide polymorphisms (SNPs) these rarely investigated. The Fagerström Test for Nicotine Dependence (FTND) score was used to assess 2616 male Chinese Han smokers. Both association interaction analysis were examine variants FTND. Further, expression...
DNA methylation is a key transcription regulator, whose aberration was ubiquitous and important in most cancers including hepatocellular carcinoma (HCC). Whole-genome bisulfite sequencing (WGBS) conducted for comparison of tumor adjacent tissues from 33 HCC patients, accompanying RNA-seq to determine differentially methylated region-associated, expressed genes (DMR-DEGs), which were independently replicated the TCGA-LIHC cohort experimentally validated via 5-aza-2-deoxycytidine (5-azadC)...
As one of the common psychiatric diseases, depression poses serious threats to human health. Although many genes have been nominated for depression, few them were investigated in details at molecular level. To demonstrate Frizzled class receptor 6 (FZD6) functions through disrupting Wnt/β-catenin signal pathway. The FZD6 edited cell line and mouse model generated by using CRISPR/Cas9 technique. expression key proteins pathway was determined qRT-PCR Western blotting, respectively. Animal...