A5100404187- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Dialysis and Renal Disease Management
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Opportunistic and Delay-Tolerant Networks
- Chemotherapy-induced organ toxicity mitigation
- Acute Kidney Injury Research
- Geothermal Energy Systems and Applications
- Muscle and Compartmental Disorders
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
- Helicobacter pylori-related gastroenterology studies
- Genomics, phytochemicals, and oxidative stress
- Kruppel-like factors research
- Autophagy in Disease and Therapy
- Microbial Applications in Construction Materials
- Neurological Complications and Syndromes
- Liver Diseases and Immunity
Jiangsu Province Hospital
2016-2024
Chinese Academy of Sciences
2024
Institute of Zoology
2024
Nanjing Medical University
2015-2024
Southeast University
2019-2024
China Railway Construction Corporation (China)
2024
Huazhong Agricultural University
2024
Kangda College of Nanjing Medical University
2023
Shougang (China)
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding mechanisms CDDP resistance can greatly improve therapeutic efficacy in GC. Circular RNAs (circRNAs) are a class noncoding whose functions related to pathogenesis cancer, but, GC remains unknown. circAKT3 (hsa_circ_0000199, circRNA originating from exons 8, 9, 10, and 11 AKT3 gene) was identified by RNA sequencing verified quantitative reverse...
Glucose metabolism reprogramming, which is a well-established characteristic of multiple cancers, demands higher rate glycolysis to meet the increasing for macromolecular synthesis and maintain rapid proliferation in hypoxic environment. However, mechanism underlying this switch remains be elucidated. In study, we investigated function circular RNA MAT2B (circMAT2B) hepatocellular carcinoma (HCC) glucose reprogramming malignancy. CircMAT2B was identified by bioinformatics analysis Gene...
Abstract Peritoneal metastasis is a primary metastatic route for gastric cancers, and the mechanisms underlying this process are still unclear. mesothelial cells (PMCs) undergo mesothelial-to-mesenchymal transition (MMT) to provide favorable environment cancer cells. In study, we investigated how exosomal miR-21-5p induces MMT promotes peritoneal metastasis. Gastric (GC)-derived exosomes were identified by transmission electron microscopy western blot analysis, then uptake of was confirmed...
Cisplatin (CDDP) resistance is a major clinical problem associated with poor prognosis in gastric cancer (GC) patients. In this study, we performed integrated analysis of TCGA data from microRNAs (miRNAs) expression matrix GC patients who received CDDP-based chemotherapy GEO dataset which contains differential miRNAs profiles CDDP-resistant and -sensitive cell lines. We identified miR-148a-3p downregulation as key step involved CDDP resistance. Using cohort consisting 105 therapy, found that...
Emerging evidence suggested that miRNAs can function as oncogenes or tumor suppressors by regulating downstream target genes. miR-324-3p has been reported to in several carcinomas, but its role gastric cancer (GC) is still unknown. This study aims explore the effects of on development GC. Expression was examined GC cells and tissues qRT-PCR. Effects were evaluated cell vitality assay, colony formation migration flow cytometric assay. The dual luciferase assay used verify whether could...
Abstract Increasing evidence indicates that dysregulation of microRNAs (miRNAs) plays a crucial role in human malignancies. Here, we showed microRNA-422a (miR-422a) expression was dramatically downregulated gastric cancer (GC) samples and cell lines compared with normal controls, its level inversely related to tumor size depth infiltration. Functional studies revealed the overexpression miR-422a GC cells suppressed proliferation migration, drove metabolic shift from aerobic glycolysis...
Abstract Objectives It has been accounted that miR‐664a‐3p different functions in several malignancies; however, the precise role and underlying mechanism gastric cancer have not elucidated. Our study aims to explore function of on progression (GC). Methods qRT‐PCR was applied detect expression GC tissues cells. The vitro were examined by cell proliferation assay, transwell assay. Related proteins epithelial‐mesenchymal transition (EMT) signal pathway evaluated Western blot...
The zinc finger protein 143 (ZNF143) is a transcription factor, which regulates many cell cycle-associated genes. ZNF143 expressed strongly in multiple solid tumors. However, the influence of on gastric cancer (GC) remains largely unknown. In this study, we investigated mRNA level GC tissues and cells by quantitative real-time PCR (qRT-PCR). expression cells, signaling pathway proteins were detected Western blotting. Transwell assay wound healing performed to explore effects for migration...
Trefoil Factor 1 (TFF1, also named pS2), which serves as the gastrointestinal mucosal protector, is known gastric-specific tumor suppressor gene. However, genetic variants of TFF1 are still not well studied. In our study, we aim to explore effects tagging single nucleotide polymorphisms (tagSNPs) on risk and prognosis gastric cancer. Seven tagSNPs gene were first analyzed in discovery set, was consisted 753 cases 950 cancer-free controls. Then, validation set (940 1,042 controls) used for...
The purpose of this study was to investigate the expression HNF-1β in various types epithelial ovarian cancers and discuss its utilization diagnosis clear cell carcinoma (OCCC). This designed detect proteins 27 OCCCs, 35 high-grade serous carcinomas, 21 endometrioid adenocarcinomas, 10 mucinous 2 transitional 13 metastatic Krukenberg tumors by EnVision immunohistochemical system. Twenty-three (85.2%) OCCCs showed diffuse moderate strong nuclear staining for HNF-1β. In cancers, detected 1...
Gastric cancer (GC) has a poor prognosis and is leading cause of cancer-related death. Optimal therapeutic targets have not been identified. AQP3 capable transporting glycerol across the cytomembrane. Previous studies shown that involved in proliferation, invasion migration by regulating lipid metabolism diverse cell types. However, potential roles AQP3-related apoptosis GC remain unclear. In this study, we observed expression was upregulated tumor tissues, positively correlated with size,...
This study was aimed at identifying the role of zinc finger protein 143 (ZNF143) in gastric cancer (GC) progression. The impact ZNF143 on proliferation ability and apoptosis GC cells detected. expression related targeted genes determined using Western blot analysis. reactive oxygen species (ROS) level examined ROS generation assay. vivo tumor xenograft ectopic overexpression promoted cells, while its knockdown reduced effect vitro. downregulation facilitated cell apoptosis. decreased...
Abstract MicroRNAs are a class of small non-coding RNAs which act as oncogenes or tumor suppressors through targeting specific mRNAs. Colorectal cancer (CRC) is one the most common malignancies worldwide. MiR-3622a-3p found to be decreased in colorectal by analyzing data from TCGA database and there few reports about role miR-3622a-3p cancers. Our research aimed explore effects on CRC. was down-regulated CRC tissues cells qRT-PCR. The effect proliferation, apoptosis, cell cycle, migration...
Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage, and inflammatory responses, are closely linked to cisplatin-induced nephrotoxicity. Adenosine, emerging as a key regulatory molecule, is mostly protective in the pathophysiology of diseases. A previous study showed some adenosine receptors led renal protection against ischemia-reperfusion injury. However, these receptor agonists lack useful therapeutic index due cardiovascular side effects. We...
Abstract The sideroflexin (SFXN) family is a group of mitochondrial membrane proteins. Although the function SFXN in mitochondria has been widely recognized, expression levels, role, and prognostic value this breast cancer (BC) have not clearly articulated systematically analysed. In our research, SFXN1 SFXN2 were significantly upregulated BC versus normal samples based on Gene Expression Profiling Interactive Analysis 2 Human Protein Atlas databases. We found that high was related to poor...
Background: Mounting evidence suggests that mitochondrial dysfunction contributes to lupus nephritis (LN) pathogenesis. Mitochondrial pyruvate carrier 1 (MPC1) and 2 (MPC2) mediating transport from the cytoplasm matrix, determines cell survival cellular energy supply. Here, we aimed investigate association of expression with clinical histological features in LN. Methods: Patients biopsy-proven proliferative LN (class III class IV, n=18) membranous V, were included. Expression MPC1 MPC2...