Sen Li

ORCID: 0000-0001-8584-2175
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About
Contact & Profiles
Research Areas
  • Spine and Intervertebral Disc Pathology
  • Medical Imaging and Analysis
  • Spinal Fractures and Fixation Techniques
  • Musculoskeletal pain and rehabilitation
  • Osteoarthritis Treatment and Mechanisms
  • Food composition and properties
  • Diet and metabolism studies
  • Nitric Oxide and Endothelin Effects
  • Reconstructive Surgery and Microvascular Techniques
  • Gut microbiota and health
  • Laser Applications in Dentistry and Medicine
  • Tendon Structure and Treatment
  • Hematopoietic Stem Cell Transplantation
  • Adipose Tissue and Metabolism
  • Lymphatic System and Diseases
  • Alzheimer's disease research and treatments
  • Spondyloarthritis Studies and Treatments
  • Pain Mechanisms and Treatments
  • Spinal Cord Injury Research
  • Musculoskeletal synovial abnormalities and treatments
  • Autoimmune and Inflammatory Disorders Research
  • Physical Activity and Health
  • Bee Products Chemical Analysis
  • Molecular Communication and Nanonetworks
  • Calpain Protease Function and Regulation

University of Shanghai for Science and Technology
2019-2025

University of Copenhagen
2025

Nanchang University
2024

Nanjing Drum Tower Hospital
2023-2024

Daqing City People's Hospital
2013-2024

Hangzhou Normal University
2024

Southwest Medical University
2016-2024

Harbin Medical University
2013-2024

Xi'an Jiaotong University
2017-2024

Fudan University
2023

The present study aimed to investigate the composition and potential anticancer activities of essential oils obtained from two species, myrrh frankincense, by hydrodistillation. Using gas chromatography-mass spectrometry (GC-MS), 76 99 components were identified in frankincense oils, respectively, with most abundant components, 2-Cyclohexen-1-one, 4-ethynyl-4-hydroxy-3,5,5-trimethyl- n-Octylacetate, accounting for 12.01 34.66%, respectively. effects independently as a mixture, on five tumor...

10.3892/ol.2013.1520 article EN Oncology Letters 2013-08-08

Background: Acellular dermal matrix (AlloDerm) is used frequently in a variety of reconstructive procedures. Although it clear that AlloDerm revascularized by host tissues, the mechanisms which vascularization and tissue incorporation occur remain essentially unknown. The purpose this experiment was to delineate time course composition cell infiltrate into an composite flap. Methods: A flap based on superficial inferior epigastric pedicle rat developed obtain specimens at 3, 7, 14 days after...

10.1097/01.prs.0000302505.43942.07 article EN Plastic & Reconstructive Surgery 2008-04-01

Ischemia reperfusion (IR)-induced lung injury is a major cause of primary graft failure after transplantation. In this study, Manning and colleagues examine whether bone-marrow derived mesenchymal stem cells engineered to secrete IL-10 can prevent IR in rat model. Ischemia–reperfusion (IR) an important viral interleukin-10 (vIL-10)-engineered (MSCs) were tested for their ability injury. Bone marrow-derived MSCs transduced with rvIL-10-retrovirus. After 120 min warm left ischemia, rats...

10.1089/hum.2009.147 article EN Human Gene Therapy 2010-01-26

Objective Unilateral biportal endoscopic (UBE) surgery has recently been used as a minimally invasive procedure for the treatment of lumbar spinal stenosis and is associated with less perioperative blood loss. However, hidden loss (HBL) may be neglected during UBE. This study aimed to examine volume HBL discuss influential risk factors unilateral surgery. Methods From January 2022 August 2022, 51 patients underwent percutaneous at Department Spinal Surgery Affiliated Traditional Chinese...

10.1111/os.14009 article EN cc-by-nc-nd Orthopaedic Surgery 2024-02-21

Abstract Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion, and metastasis. However, the impact global adipose tumor growth drug development by targeting remain largely unexplored. Here we show therapeutic paradigm drugs effective for treating various types browning tissues. Mirabegron, clinically available overactive bladders, displays potent anticancer effects animal models, including...

10.1038/s41467-023-43350-8 article EN cc-by Nature Communications 2023-11-22

Abstract The HoloFood project used a hologenomic approach to understand the impact of host–microbiota interactions on salmon and chicken production by analysing multiomic data, phenotypic characteristics, associated metadata in response novel feeds. project’s raw derived analyses, are deposited public, open archives (BioSamples, European Nucleotide Archive, MetaboLights, MGnify), so making use these diverse data types may require access multiple resources. This is especially complex where...

10.1093/database/baae112 article EN cc-by Database 2025-01-01

Oncolytic viruses based on herpes simplex virus type 1 (HSV-1) are able to infect and lyse a variety of malignant cell lines. However, there is variability in the degree tumor susceptibility, cancer determinants HSV sensitivity poorly defined. Nectin-1 surface adhesion molecule that functions as cellular receptor envelope glycoprotein D (gD). We assessed nectin-1 expression predictor oncolytic sensitivity. A panel human squamous carcinoma lines was evaluated for viral entry, replication,...

10.1038/sj.mt.6300009 article EN cc-by-nc-nd Molecular Therapy 2006-12-13

Abstract In recent years, the development of micromotors for biomedical applications has surged. However, challenges such as immunogenicity and difficulty in controlling motion direction have hindered their clinical translation. this study, Chlamydomonas reinhardtii, a natural unicellular green microalgae known its biocompatibility phototaxis properties hydrogen peroxide environments is applied, micromotor efficient drug delivery photodynamic therapy. 5‐Aminolevulinic acid‐loaded liposomes...

10.1002/adfm.202411070 article EN Advanced Functional Materials 2024-12-20

In the present study, we aimed to have a comprehensive understanding of nucleus pulposus related long noncoding RNA (lncRNA) and mRNA expression profiles in intervertebral disc degeneration (IDD). total, 2418 mRNAs 528 lncRNAs were found be differentially expressed IDD group compared with Control group. Combining microarray datasets sequencing data, 5 overlapping DEMs 7 DELs identified. NF-κB signaling pathway, PI3K-Akt pathway Wnt/β-catenin strongly linked enriched GO terms KEGG pathways....

10.1016/j.ygeno.2023.110570 article EN cc-by-nc-nd Genomics 2023-02-04

Abstract Objective This study introduces a minimally invasive technique for efficient three-column reconstruction, augmentation, and stabilization of osteoporotic thoracolumbar burst fractures (OTLBFs). Methods Sixty-eight patients with OTLBFs no neurological deficits were included from July 2019 to September 2020. The divided into two groups: the simple percutaneous kyphoplasty (PKP) group ( n = 32) combined pediculoplasty (PKCPP) 36). clinical radiological outcomes assessed during minimum...

10.1186/s13018-024-04562-w article EN cc-by Journal of Orthopaedic Surgery and Research 2024-01-22

Abstract The clear aligner, commonly utilized in orthodontic treatment for malocclusion, necessitates the quantification of forces, which is highly demanded by doctors enhancing risk management and efficiency. However, current technology still faces obstacles achieving conformal integration pressure sensors onto aligners with large curvature real‐time monitoring forces. In this paper, a iontronic sensing aligner (CSA) proposed based on flexible mechanism, conformally integrates sensor to...

10.1002/adfm.202408376 article EN Advanced Functional Materials 2024-10-04

Neuropathic pain is a chronic disease with hallmarks such as allodynia and hyperalgesia. Previous studies have shown that the transforming growth factor-β superfamily acts protecting factor against neuropathic pain. In current study, we found differentiation 10 (GDF10), which belongs to superfamily, mainly expressed in superficial layers of spinal dorsal horn neurons it was dramatically downregulated after nerve ligation N-methyl-D-aspartate (NMDA) intrathecal infusion. Moreover, decrease...

10.1097/wnr.0000000000000785 article EN Neuroreport 2017-04-07
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