A5071366091- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Seaweed-derived Bioactive Compounds
- Gut microbiota and health
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Child Nutrition and Water Access
- Smart Agriculture and AI
- Environmental DNA in Biodiversity Studies
- Echinoderm biology and ecology
- COVID-19 epidemiological studies
- HIV/AIDS oral health manifestations
- Marine Sponges and Natural Products
- Gene expression and cancer classification
- Healthcare innovation and challenges
- Bioinformatics and Genomic Networks
- Frailty in Older Adults
- Aging and Gerontology Research
- Proteoglycans and glycosaminoglycans research
- Global Health and Epidemiology
European Bioinformatics Institute
2019-2025
National AIDS Research Institute
2002-2025
Matís (Iceland)
2012-2024
University of Iceland
2012-2013
National University Hospital of Iceland
2013
Glasgow Royal Infirmary
1974
MGnify (http://www.ebi.ac.uk/metagenomics) provides a free to use platform for the assembly, analysis and archiving of microbiome data derived from sequencing microbial populations that are present in particular environments. Over past 2 years, (formerly EBI Metagenomics) has more than doubled number publicly available analysed datasets held within resource. Recently, an updated approach been unveiled (version 5.0), replacing previous single pipeline with multiple pipelines tailored...
Abstract The MGnify platform (https://www.ebi.ac.uk/metagenomics) facilitates the assembly, analysis and archiving of microbiome-derived nucleic acid sequences. provides access to taxonomic assignments functional annotations for nearly half a million analyses covering metabarcoding, metatranscriptomic, metagenomic datasets, which are derived from wide range different environments. Over past 3 years, has not only grown in terms number datasets contained but also increased breadth provided,...
Abstract The HoloFood project used a hologenomic approach to understand the impact of host–microbiota interactions on salmon and chicken production by analysing multiomic data, phenotypic characteristics, associated metadata in response novel feeds. project’s raw derived analyses, are deposited public, open archives (BioSamples, European Nucleotide Archive, MetaboLights, MGnify), so making use these diverse data types may require access multiple resources. This is especially complex where...
Background & objectives This study was performed to assess the suitability of dried blood spot (DBS) samples for serological screening syphilis. Methods Two hundred paired DBS and plasma collected from six sexually transmitted infection (STI) clinics during year 2023 were tested using three kits - Treponema pallidum haemagglutination assay (TPHA), Syphilis Total Ab ErbaLisa after standardization dilutions elutes considering results as a true status. Results The TPHA showed 89 per cent...
A thermophilic, aerobic, Gram-stain-negative, filamentous bacterium, strain PRI-4131(T), was isolated from an intertidal hot spring in Isafjardardjup, NW Iceland. The grew chemo-organotrophically on various carbohydrates. temperature range for growth 40-65 °C (optimum 55 °C), the pH 6.5-9.0 7.0) and NaCl 0-3 % (w/v) 0.5 %). Phylogenetic analysis based 16S rRNA gene sequences revealed that PRI-4131(T) represented a distinct lineage within class Caldilineae of phylum...
To determine if the early immunological and virological events of HIV infection are unique in a setting with limited access to health care HIV-1 subtype C infection, we undertook prospective cohort study characterize natural history viral load CD4+ T lymphocyte counts individuals recent seroconversion India. were prospectively measured for up 720 days 46 antiviral drug-naive persons very documented by antibody seroconversion. RNA levels subsequently on reposited plasma samples from these...
Using new biomarker data from the 2010 pilot round of Longitudinal Aging Study in India (LASI), we investigate education, gender, and state-level disparities health. We find that hemoglobin level, a marker for anemia, is lower respondents with no schooling (0.7 g/dL less adjusted model) compared to those some formal education also females than males (2.0 model). In addition, about one third our sample aged 45 or older have high C-reaction protein (CRP) levels (>3 mg/L), an indicator...
Objectives This study aims to validate a modified dried blood spot (DBS)‐based glycosylated hemoglobin (HbA1c) assay protocol, after pretest in India showed poor correlation between the original DBS‐based protocol and venous results. Methods The was tested on different chemistry analyzers then simplified at University of Washington (UW). A second conducted using 44 quality control specimens. Results Data from UW indicated that, coefficients DBS results were above 0.98 both Bio‐Rad Olympus...
Background: We aimed to determine the anti-SARS-CoV-2 IgG antibodies among people living with HIV (PLHIV) in Pune, India. Methods: This cross-sectional study was conducted between March 2021 and June 2021. Demographic clinical information related coronavirus disease 2019 (COVID-19) were recorded on structured questionnaires. Blood samples collected tested for using commercial ELISA. Results: Of 405 infected individuals enrolled study, 223(55.1%) females. Mean age CD4 count of participants 42...
Abstract Understanding the development of functional attributes host-associated microbial communities is essential for developing novel microbe-based solutions sustainable animal production. We applied multi-omics to 388 broiler chicken caecal samples characterise and model dynamics 822 bacterial strains. Although community diversity metrics increased with age as expected, overall metabolic capacity activity microbiota exhibited an unexpected decrease. This drop occurred due spread...
While metagenome sequencing may provide insights on the genome sequences and composition of microbial communities, metatranscriptome analysis can be useful for studying functional activity a microbiome. RNA-Seq data provides possibility to determine active genes in community how their expression levels depend external conditions. Although field metatranscriptomics is relatively young, number projects related increases every year scope its applications expands. However, there are several...
Measurement of C-reactive protein (CRP), a marker inflammation, in dried blood spots has been increasingly incorporated into community-based social surveys internationally. Although the spot-based CRP assay protocol validated United States, it remains unclear whether laboratories other less-developed countries can generate results similar quality. We therefore conducted external quality monitoring for measurement Indonesia Family Life Survey and Longitudinal Aging Study India. Our show that...
Describes the data collection protocol, laboratory and distributional characteristics of biomarker data, one three components Longitudinal Aging Study in India.
Abstract Shotgun metagenomics provides access to genetic information of microbes in a culture-independent manner. The recovery metagenome assembled genomes (MAGs) these organisms enables in-depth analysis the functional potential these, often elusive, organisms. While workflows for prokaryotic MAGs are established, eukaryotic species seldom reported. To address this, we developed new approaches improve and applied large collections metagenomes an effort systematically identify both MAGs....
<ns3:p>Microbiome research has grown substantially over the past decade in terms of range biomes sampled, identified taxa, and volume data derived from samples. In particular, experimental approaches such as metagenomics, metabarcoding, metatranscriptomics metaproteomics have provided profound insights into vast, hitherto unknown, microbial biodiversity. The ELIXIR Marine Metagenomics Community, initiated amongst researchers focusing on marine microbiomes, concentrated promoting standards...
Sulfation is gaining increased interest due to the role of sulfate in bioactivity many polysaccharides marine origin. Hence, sulfatases, enzymes that control degree sulfation, are being more extensively researched. In this work, a novel sulfatase (SulA1) encoded by gene sulA1 was characterized. The sulA1-gene located upstream chondroitin lyase encoding genome Arthrobacter strain (MAT3885). produced Escherichia coli. Based on primary sequence, enzyme classified under family 1 and two...
Under India’s National AIDS Control Program (NACP), WHO recommended strategy of using three rapid tests is adopted for diagnosis HIV in an asymptomatic individual. Since the NACP has a stringent kit evaluation procedure and due to availability newer third generation Rapid Diagnostic Tests (RDTs) it may be possible adapt two test instead strategy. The authors reviewed programmatic data on testing explore whether use as against could feasible approach without compromising quality readability...