A5038397286- Congenital heart defects research
- Traditional Chinese Medicine Analysis
- Congenital Heart Disease Studies
- Plant-based Medicinal Research
- Heart Rate Variability and Autonomic Control
- RNA modifications and cancer
- Nuclear Receptors and Signaling
- Bioactive Natural Diterpenoids Research
- Blood Coagulation and Thrombosis Mechanisms
- Blood Pressure and Hypertension Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Heart rate and cardiovascular health
- Cardiac Health and Mental Health
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacological Effects of Natural Compounds
- Cytokine Signaling Pathways and Interactions
- Williams Syndrome Research
- Neuroendocrine regulation and behavior
- Cholesterol and Lipid Metabolism
- Genomic variations and chromosomal abnormalities
- Psoriasis: Treatment and Pathogenesis
- Macrophage Migration Inhibitory Factor
Renji Hospital
2025
Shanghai Jiao Tong University
2020-2025
Shanghai Cancer Institute
2025
Shanghai University of Traditional Chinese Medicine
2022-2023
Central Hospital of Putuo District
2022
Huazhong University of Science and Technology
2016-2021
Shanghai Children's Medical Center
2020-2021
Shandong Agricultural University
2009
BACKGROUND: Mounting evidence indicates that nuclear receptors play a critical regulatory role in platelet pathophysiology and thrombotic disorders. Although NR4A (the receptor subfamily 4 group A) plays an important cardiovascular pathophysiology, the expression profile biological function of member 1 (NR4A1) platelets have never been reported. METHODS: We evaluated functions underlying mechanisms NR4A1 activation thrombus formation using platelet-specific NR4A1-deficient mice...
The interleukin 1 family plays an important role in the immune and inflammatory responses. Coronary artery disease (CAD) is a chronic disease. However, genetic association between IL-37, seventh member of IL-1 family, CAD unknown. Here we show that single nucleotide polymorphism IL-37 gene (rs3811047) confers significant risk CAD. We have performed analysis rs3811047 two independent populations with 2,501 patients 3,116 controls from China. Quantitative RT-PCR has been to determine if...
Chromosome 4q deletion is one of the most frequently detected genomic imbalance events in congenital heart disease (CHD) patients. However, a portion CHD-associated deletions without known CHD genes suggests unknown within these intervals. Here, we have shown that knockdown SORBS2 , interval gene, disrupted sarcomeric integrity cardiomyocytes and caused reduced cardiomyocyte number human embryonic stem cell differentiation model. Molecular analyses revealed decreased expression second field...
ObjectiveTo observe the effect of renal artery denervation (RDN) on cardiac function in patients with acute myocardial infarction after percutaneous coronary intervention (AMI-PCI).MethodsThis is a single-centre, prospective randomized controlled study. A total 108 AMI-PCI were randomly assigned to RDN group or control at 1:1 ratio. All received standardized drug therapy PCI, and underwent additional 4 weeks PCI. The follow-up period was 6 months RDN. Echocardiography-derived parameters,...
Congenital heart defects (CHDs) are the most common birth worldwide. 22q11.2 deletion syndrome is microdeletion disorder that has been frequently associated with conotruncal malformations. By now, dosage-sensitive gene TBX1 adopted as major pathogenic responsible for deletion, which regulated by canonical Wnt/β-catenin signaling pathway in outflow tract development. Here, we report long noncoding RNA (lncRNA) lnc-TSSK2-8, encompassed region, can activate protecting β-catenin from...
The combination of Salvia miltiorrhiza (Danshen) and rivaroxaban is a promising treatment option in clinical practice China, but the herb-drug interaction between Danshen remains unclear. Therefore, this study aims to reveal rivaroxaban. We not only investigated inhibitory properties tablet on metabolism rat human liver microsomes also evaluated effects its eight active components (dihydrotanshinone I, tanshinone IIA, cryptotanshinone, danshensu, salvianolic acid A, B, C) cytochrome P450...
Abstract Background Hypertension is a kind of clinical syndrome, characterized by the increase systemic arterial pressure. There lack identifiable triggers and predictors hypertensive disease in response to treatment at rest during exercise. In this study, mathematical model was used screen compare indicators related changes exercise between normotensive individuals. Methods Blood pressure ultrasound-related indicators, blood biochemical metabolic compounds were collected logistic regression...
Abstract Chromosome 4q deletion is one of the most frequently detected genomic imbalance events in congenital heart disease (CHD) patients. However, a portion CHD-associated deletions do not include known CHD genes. Alignment those defined minimal overlapping region including only gene- SORBS2 . Histological analysis Sorbs2 -/- revealed atrial septal hypoplasia/aplasia or double septum. Mechanistically, had dual role maintaining sarcomeric integrity cardiomyocytes and specifying fate second...
Objective : The purpose of this study was to explore the effects renal denervation (RDN) on cardiac function and malignant arrhythmia in patients with reduced left ventricular ejection fraction (HFrEF) narrow QRS treated an implantable cardioverter defibrillator (ICD). Methods: A total 20 eligible HFrEF [left (LVEF) <40%] complexes (QRS duration <120 ms) were randomized into either ICD plus RDN group or only during 17 April 2014 22 November 2016. Clinical data, including...