A5014890799- Seaweed-derived Bioactive Compounds
- Cancer Treatment and Pharmacology
- Adipokines, Inflammation, and Metabolic Diseases
- Microbial Natural Products and Biosynthesis
- Regulation of Appetite and Obesity
- Biological Activity of Diterpenoids and Biflavonoids
- Marine and coastal plant biology
- Marine Sponges and Natural Products
- Synthetic Organic Chemistry Methods
- Berberine and alkaloids research
- Adipose Tissue and Metabolism
- Echinoderm biology and ecology
- Alzheimer's disease research and treatments
- Plant-Microbe Interactions and Immunity
- Natural Antidiabetic Agents Studies
- Phytoestrogen effects and research
- Chemical and Physical Properties in Aqueous Solutions
- Protein Hydrolysis and Bioactive Peptides
- Genetics, Aging, and Longevity in Model Organisms
- Traditional Chinese Medicine Analysis
- Fatty Acid Research and Health
- Polysaccharides Composition and Applications
- Natural product bioactivities and synthesis
- Selenium in Biological Systems
- Pharmacology and Obesity Treatment
National Research Council Canada
2014-2024
Dalhousie University
2018
Culture Resource
2016
Health PEI
2016
University of Prince Edward Island
2011-2014
National Academies of Sciences, Engineering, and Medicine
2011
Chinese Academy of Medical Sciences & Peking Union Medical College
1998-2009
Dalian Institute of Chemical Physics
2009
Chinese Academy of Sciences
2009
Henan University of Traditional Chinese Medicine
2007
Abstract Background We have previously shown that lipophilic components (LPC) of the brown seaweed Ascophyllum nodosum (ANE) improved freezing tolerance in Arabidopsis thaliana . However, mechanism(s) this induced stress is largely unknown. Here, we investigated LPC changes transcriptome and metabolome A. undergoing stress. Results Gene expression studies revealed accumulation proline was mediated by an increase synthesis genes P5CS1 P5CS2 a marginal reduction dehydrogenase ( ProDH ) gene....
We screened seaweed species from Atlantic Canada for antidiabetic activity by testing extracts α-glucosidase inhibitory effect and glucose uptake stimulatory activity. An aqueous ethanolic extract of Ascophyllum nodosum was found to be active in both assays, inhibiting rat intestinal (IC 50 = 77 μg/mL) stimulating basal into 3T3-L1 adipocytes during a 20-minute incubation about 3-fold (at 400 μg/mL extract). Bioassay-guided fractionation the A. showed that inhibition associated with...
Gastrointestinal microbial communities are diverse and composed of both beneficial pathogenic groups. Prebiotics, such as digestion-resistant fibers, influence the composition gut microbiota, can contribute to improvement host health. The red seaweed Chondrus crispus is rich in dietary fiber oligosaccharides, however its prebiotic potential has not been studied date.Prebiotic effects were investigated with weaning rats fed a cultivated C. crispus-supplemented diet. Comparison standards...
Liuwei Dihuang (LWDH), a classic Chinese medicinal formula, has been used to improve or restore declined functions related aging and geriatric diseases, such as impaired mobility, vision, hearing, cognition memory. Here, we report on the effect possible mechanisms of LWDH mediated protection β-amyloid (Aβ) induced paralysis in Caenorhabditis elegans using ethanol extract (LWDH-EE) water (LWDH-WE). Chemical profiling quantitative analysis revealed presence different levels bioactive...
Abstract Pseudoalteromonas is a globally distributed marine-associated genus that can be found in broad range of aquatic environments, including association with macroalgal surfaces where they may take advantage these rich sources polysaccharides. The metabolic systems confer the ability to metabolize this abundant form photosynthetically fixed carbon, however, are not yet fully understood. Through genomics, transcriptomics, microbiology, and specific structure-function studies pathway...
Japanese knotweed (Fallopia japonica, also known as Polygonum cuspidatum) is a common invasive plant species on Prince Edward Island (PEI), Canada, whereas it has been used in Chinese medicine and more recently raw material for extracting resveratrol. This paper reports the quantification of resveratrol, polydatin, emodin, physcion roots, stems, leaves samples from PEI British Columbia (BC), nine provinces China, by ultraperformance liquid chromatography (UPLC). The results showed that root...
We investigated the metabolic effects of betaine (Bet) supplementation on CTP:phosphoethanolamine cytidylyltransferase/Pcyt2 heterozygous mice (HET). HET received either no treatment or were allowed access to 1% Bet supplemented water for 8 weeks. As we previously showed with choline (Cho), improved hypertriglyceridemia and hepatic steatosis in HET. The protection from obesity associated reduced increased lipid breakdown adipocytes was attributed energy requirements metabolism elimination...
The present study was carried out to determine the effect of berberine on glucose homeostasis and several biomarkers associated with insulin sensitivity in male Wistar rats intraperitoneal injection streptozotocin (STZ)-induced diabetes. Rats fasting blood 16.7 mmol/L after 2 weeks STZ were divided into two groups. One group used as diabetic control another treated by gavage feeding 100 mg/kg/d water containing 0.5% carboxymethyl cellulose. A without receiving normal control. After 7 weeks,...