A5100357348- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Saffron Plant Research Studies
- Alzheimer's disease research and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Phytochemistry and Biological Activities
- Medicinal Plants and Bioactive Compounds
- Apelin-related biomedical research
- Neuropeptides and Animal Physiology
- Alcohol Consumption and Health Effects
- Medicinal plant effects and applications
- Cannabis and Cannabinoid Research
- Peroxisome Proliferator-Activated Receptors
- Chemotherapy-related skin toxicity
- Quinazolinone synthesis and applications
- Ion channel regulation and function
- Neurological Disorders and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Biochemical Acid Research Studies
- Flavonoids in Medical Research
- Adipose Tissue and Metabolism
- Cholesterol and Lipid Metabolism
Ningbo Medical Center Lihuili Hospital
2022
Ningbo University
2022
Chongqing Technology and Business University
2005-2016
National Research Council Canada
2013
The emerging data show that the insulinotrophic hormone glucagon-like peptide-1(GLP-1) and its agonist extendin-4 have neurotrophic function to inducing neuronal differentiation of PC12 cells prevent neurons damage challenged by oxidative stress. Here, with model high throughput screen for GLP-1 receptor agonists, we identify geniposide is a novel receptor. Furthermore, induces resulting neurites outgrowth; also observe an increase in expression growth-associated protein-43. U0126, selective...
Oxidative stress in brain is emerging as a potential causal factor aging and age-related neurodegenerative disorders. A large body of evidence shows that induction endogenous antioxidative proteins seems to be reasonable strategy for delaying the progression cell injury. In this study, geniposide upregulates expression heme oxygenase-1 (HO-1) attenuate apoptosis induced by 3-morpholinosydnonimine hydrochloride (SIN-1) primary cultured hippocampal neurons. Furthermore, induces nuclear...
Glucose-stimulated insulin secretion (GSIS) is essential to the control of metabolic fuel homeostasis. The impairment GSIS a key element β-cell failure and one causes type 2 diabetes mellitus (T2DM). Although KATP channel-dependent mechanism has been broadly accepted for several decades, it does not fully describe effects glucose on secretion. Emerging evidence suggested that other mechanisms are involved. present study demonstrated geniposide enhanced in response stimulation low or...
Geniposide is one of the main compounds in Gardenia jasminoides ELLIS and has many pharmacological activities, but its anti-hyperglycemic activity not yet been fully explored. This study was designed to determine, for first time, how geniposide from G. regulates hepatic glucose production, underlying mechanisms. During vitro study, we found inhibitory effect on production partly through AMP-activated protein kinase (AMPK) activation HepG2 cells. significantly inhibited a dose-dependent...
We reported previously that geniposide showed neurotrophic and neuroprotective activities with the activation of glucagons-like peptide 1 receptor (GLP-1R) in neurons. The current study was designed to further investigate protective effect on β-amyloid (Aβ)-induced cytotoxicity. Our results pre-incubation prevented Aβ1-42-induced cell injury primary cultured cortical Geniposide also induced expression insulin-degrading enzyme (IDE), a major degrading protease Aβ, dose-dependent manner....
Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA inhibition, in turn it evokes epileptiform activities hippocampal neurons. It also shown acutely induce epileptic seizure behavior freely moving rats. However, whether CTZ induced rats could develop have recurrent still remains unknown. In the current study, we demonstrated that 46% of developed as well EEG with a starting latency between 2 weeks several months. those chronic 6...
Background Safflower, phellodendron, scutellaria baicalensis, coptis, and gardenia (SPSCG) are medicinal plants with a wide range of anti-inflammatory antioxidant effects. However, the related mechanism SPSCG against hand-foot syndrome (HFS) has yet to be revealed. Objective To investigate mechanisms in treatment HFS using Network Pharmacology. Methods Active ingredients targets for were screened by Chinese Medicine Systems Pharmacology (TCMSP) Swiss Target Prediction databases. Potential...
To date, peroxisome proliferator-activated receptors (PPARs) are becoming the new therapeutic targets for treatment of metabolic diseases, such as Type 2 diabetes, obesity, and cardiovascular disease. In this study, a cell-based high-throughput PPARs (PPARα/β/γ) model was developed screening agonists. The conditions were evaluated through analyzing expression value luciferase. Finally, 24 h drug acting time, 5 times dilution factor luciferase zymolyte, about × 104 cells/ well on HeLa cells...