A5102710075- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Epilepsy research and treatment
- Pharmacological Effects of Natural Compounds
- RNA and protein synthesis mechanisms
- Lipid Membrane Structure and Behavior
- Genomics and Chromatin Dynamics
- Neuroscience of respiration and sleep
- Cancer-related molecular mechanisms research
- Heart Rate Variability and Autonomic Control
- Traditional Chinese Medicine Analysis
- Fibroblast Growth Factor Research
- Peptidase Inhibition and Analysis
- Liver Disease and Transplantation
- Neurogenesis and neuroplasticity mechanisms
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- Circular RNAs in diseases
- Nerve injury and regeneration
- Medicinal Plants and Neuroprotection
- Cannabis and Cannabinoid Research
- Liver Disease Diagnosis and Treatment
- Reproductive System and Pregnancy
- Lipid metabolism and disorders
- Ginger and Zingiberaceae research
Huangshi Central Hospital
2025
Nanjing University
2025
First Affiliated Hospital of Xiamen University
2020
Xiamen University
2020
Chongqing Technology and Business University
2007-2019
Fudan University
2010-2014
State Key Laboratory of Medical Neurobiology
2014
University of Southern California
2008
Cincinnati Children's Hospital Medical Center
2003-2006
Massachusetts Institute of Technology
1992
In the human genome, erythroid-specific hypersensitive site HS2 enhancer regulates transcription of downstream beta-like globin genes 10-50 kilobases away. The mechanism function is not known. present study employs RNA protection assays to analyze transcriptional status in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids. erythroid K562 cells which active, sequence directs synthesis long transcripts that are initiated apparently from within and elongated through...
Rheumatoid arthritis (RA) is a chronic autoimmune disease primarily marked by joint inflammation and systemic damage. This research explored the protective effects of m6A-related gene RBM15 on RA both in vivo vitro, focusing its impact NLRP3 inflammasome activation. We identified downregulation synovial biopsy samples from patients through GSE77298 analysis. Real-time PCR confirmed that expression was significantly reduced compared to healthy controls (HC). Upon LPS stimulation, M1 markers...
Autophagy defect has been detected in premature ovarian insufficiency (POI) patients. To evaluate the efficacy and explore mechanism of Zigui-Changqi Decoction (ZCD) treatment POI. Rat model POI was established to ZCD on serum hormone levels, index, cell apoptosis. The effect autophagy granulosa assessed. Network pharmacology used predict potential targets against attenuated tripterygium glycosides-induced damage tissues rats by improving moderating inhibiting apoptosis, increasing number...
Moutan Cortex has been widely used to treat various types of arthritis in traditional Chinese medicine. Paeonol is isolated as an active ingredient from Cortex. However, the effect and potential mechanism paeonol on gouty have not evaluated. In this study, rats were treated intragastrically with for consecutive 7 days. On Day 5, intra‐articularly injected monosodium urate (MSU) crystals ankle joints induce MSU‐induced (MIA). Paw volume was detected at time points. Gait score measured 24 hr...
Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA inhibition, in turn it evokes epileptiform activities hippocampal neurons. It also shown acutely induce epileptic seizure behavior freely moving rats. However, whether CTZ induced rats could develop have recurrent still remains unknown. In the current study, we demonstrated that 46% of developed as well EEG with a starting latency between 2 weeks several months. those chronic 6...
Abstract Background GABAergic deficit is one of the major mechanisms underlying epileptic seizures. Previous studies have mainly focused on alterations synaptic inhibition during epileptogenesis. Recent work suggested that tonic may also play a role in regulating epileptogenesis, but mechanism not well understood. Results We employed molecular and pharmacological tools to investigate epileptogenesis both vitro vivo . overexpressed two distinct subtypes extrasynaptic GABA A receptors, α5β3γ2...
Transcriptional cis-regulatory control regions frequently are found within non-coding DNA segments conserved across multi-species gene orthologs. Adopting a systematic gene-centric pipeline approach, we report here the development of web-accessible database resource—GenomeTraFac (Author Webpage)—that allows genome-wide detection and characterization compositionally similar cis-clusters that occur in orthologs between any two genomes for both microRNA genes as well conventional RNA-encoding...
Inbred strains of mice differ in their susceptibility to excitotoxin-induced cell death, but the genetic basis individual variation differential is unknown. Previously, we identified a highly significant quantitative trait locus (QTL) on chromosome 18 that influenced kainic acid-induced death (Sicd1). Comparison seizure-induced between reciprocal congenic lines for Sicd1 and parental background indicates genes influencing this were captured both strains. Two positional gene candidates, Galr1...
Cardiac vagal preganglionic neurones (CVPNs) show respiratory modulation in the nucleus ambiguus but not dorsal nucleus. Both types of can be activated by pulmonary C fibre afferents. Another brainstem area that has been identified as containing CVPNs is intermediate zone between and ambiguus. Experiments were carried out alpha-chloralose-anaesthetized cats to determine physiological properties these their responses afferent activation. Seven CVPN axons right cardiac branches found localized...
Purpose: To investigate the effect of total glucosides Paeonia lactiflora (TGPL) on nitric oxide (NO) production and its potential mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.Methods: cells were treated with 10 - 300 µg/ml TGPL 1 LPS. Cell survival was determined by MTT assay. NO level Griess reaction Inducible synthase (iNOS) expression inhibitor-kBα (IkBα) degradation Western blot DNA binding activity NF-kB ELISA assay using Trans AM™ kit for p65.Results: The...
Sophorae Flavescentis Radix (Kuh-seng, SFR), a Traditional Chinese Medicine (TCM), is widely used alone or within TCM formula to treat pruritus, especially histamine-independent intractable itching. In the previous study, potential antipruritic active components of SFR were screened based on cell membrane immobilized chromatography (CMIC), revealing oxymatrine (OMT) as an agent. However, low oral bioavailability (OB) OMT cannot explain effect when administered orally in clinic. this we...
Objective To compare the effects of different stent configurations on shunt failure, hepatic encephalopathy, and myelopathy after transjugular intrahepatic portosystemic (TIPS). Methods From March 2014 to June 2015, clinical data 73 hospitalized patients who met inclusion exclusion criteria, underwent TIPS for upper gastrointestinal hemorrhage caused by cirrhotic portal hypertension were retrospectively analyzed. According configuration during operation, divided into simple coated...
Blastocyst activation, referring to the blastocyst acquiring implantation competency, is determining factor for into receptive uterus. It involves process of embryonic cell differentiation contact and initiate dialog with uterine cells. Before application -omics approaches this biological event, only cellular morphological changes a small number molecules were known regulate process. This review aims discuss recent exploration global molecular during activation in mouse model, based on...