A5086866972- Pregnancy and preeclampsia studies
- Lung Cancer Diagnosis and Treatment
- Birth, Development, and Health
- Pleural and Pulmonary Diseases
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Genomic variations and chromosomal abnormalities
- Estrogen and related hormone effects
- Cardiac Imaging and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Reproductive System and Pregnancy
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Histone Deacetylase Inhibitors Research
- Congenital Diaphragmatic Hernia Studies
- Acute Myocardial Infarction Research
- RNA Research and Splicing
- Prenatal Screening and Diagnostics
- Immune cells in cancer
- Medical Research and Treatments
Wuxi Ninth People's Hospital
2024-2025
Soochow University
2022-2025
Universiti Sains Malaysia
2024
The University of Texas Health Science Center at San Antonio
2017-2023
Shanxi Medical University
2023
Sichuan University
2017-2022
West China Hospital of Sichuan University
2017-2022
Shanghai University of Medicine and Health Sciences
2020
The University of Texas at San Antonio
2019
Chaohu Hospital of Anhui Medical University
2019
Nursing professionalism plays an important role in clinical nursing. However, a clear conceptual understanding of nursing is lacking.Walker and Avant's strategy was used to analyse the concept professionalism. We searched electronic databases, including PubMed, Scopus, CINAHL, for studies published from 1965 2021. Quantitative or qualitative English that focused on were included study.The three attributes are multidimensional, dynamic, culture oriented. Based analysis, defined as providing...
The objective of this study is to explore the association between pretreatment systemic immune-inflammation index (SII) and prognosis in non-small cell lung cancer (NSCLC) patients.A literature search PubMed, EMBASE, Web Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, VIP SinoMed databases was performed from January 1, 1966 April 15, 2019, identify potential studies that assessed prognostic role SII NSCLC. hazard ratio (HR) 95% confidence interval (CI)...
Resistance to cancer treatment can be driven by epigenetic reprogramming of specific transcriptomes in favor the refractory phenotypes. Here we discover that tamoxifen resistance breast is a regulatory axis consisting master transcription factor, its cofactor, and an regulator. The oncogenic histone methyltransferase EZH2 conferred silencing expression estrogen receptor α (ERα) cofactor GREB1. In clinical specimens, induction DNA methylation particular CpG-enriched region at GREB1 promoter...
We investigated the role of exosomes derived from maternal and umbilical cord blood in regulation angiogenesis. report here that both (MEs) (UEs) significantly enhance HUVEC proliferation, migration, tube formation. Importantly, ME-treated HUVECs (MEXs) displayed increased but not proliferation or formation, compared with UE-treated (UEXs). found expression a subset migration-related microRNAs (miRNAs), including miR-210-3p, miR-376c-3p, miR-151a-5p, miR-296-5p, miR-122-5p, miR-550a-5p,...
Inflammatory myofibroblastic tumors (IMTs) are characterized by myofibroblast proliferation and an inflammatory cell infiltrate. Little is known about the molecular pathways that precipitate IMT formation. Here, we report identification of somatic mutations in UPF1, a gene encodes essential component nonsense-mediated RNA decay (NMD) pathway, 13 15 pulmonary samples. The majority occurred specific region UPF1 triggered alternative splicing. Several mRNA targets NMD pathway were upregulated...
The relationship between several inflammatory biomarkers and slow coronary flow phenomenon(SCFP) has been reported. However, the correlation neutrophil percentage-to-albumin ratio (NPAR) SCFP is lacking. In this study, we aimed to assess NPAR SCFP. A total of 228 patients were enrolled in study according diagnostic exclusion criteria. 76 included group, 152 age-matched normal (NCF) group. baseline data, laboratory parameters angiography recorded compared. values significantly higher group...
To evaluate whether the measurement of maternal serum inhibin A, activin A and placental growth factor (PlGF) at 12 + 0 to 16 weeks gestation alone or in combination with second-trimester uterine artery Doppler pulsatility index (PI) is useful predicting pre-eclampsia.This was a case-control study pre-eclampsia. From pregnant women attending their first antenatal examination 12-16 we collected samples stored them - 80 °C. All patients also underwent measure PI 22-24 weeks' gestation. We...
Background: The purpose of our cohort study was to investigate the effects pleural adhesions on perioperative outcomes in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for non-small-cell lung cancer (NSCLC). Methods: We performed a single-center retrospective analysis prospectively-maintained dataset at unit from February 2014 November 2015. Patients were divided into two groups (Group A: presence adhesions; Group B: absence adhesions) according grading system...
Vascular remodeling in the placenta is essential for normal fetal development. The previous studies have demonstrated that utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, an environmental toxicant) induces intrauterine death many species via activation of aryl hydrocarbon receptor (AhR). In current study, we compared effects 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) and TCDD on vascular rat placentas. Pregnant rats gestational day (GD) 15 were...
Developmental delay (DD) and intellectual disability (ID) are frequently associated with a broad spectrum of additional phenotypes. Chromosomal microarray analysis (CMA) has been recommended as first-tier test for DD/ID in general, whereas the diagnostic yield differs significantly among patients different comorbid conditions. To investigate genotype-phenotype correlation, we examined characteristics identified pathogenic copy number variations (pCNVs) compared yields patient subgroups...
The purpose of our study was to estimate the influence estimated intraoperative blood loss (EIBL) on postoperative cardiopulmonary complications (PCCs) in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for non-small-cell lung cancer (NSCLC).We conducted a single-center retrospective analysis clinical data consecutive institution between April 2015 and February 2016. Demographic differences PCC group non-PCC were initially assessed. Receiver operating characteristic...
To investigate the clinical manifestations of infectious mononucleosis in children different ages.Clinical data from pediatric patients with admitted May 2015 to April 2019 were retrospectively analyzed. Patients stratified into three groups (age 1-3 years, 4-6 and 7-14 years) for analysis laboratory results.Data 61 (male:female ratio 1.18:1) aged 5.15 ± 2.93 years (mean standard deviation; range: 1-14 Infectious occurred throughout year main fever (98.3%), tonsillitis (100%), tonsillar...
Background: 2-methoxyestradiol (2-ME), a natural metabolite of 17β-estradiol, is synthesized by catechol-O-methyltransferase (COMT). The aim this study was to explore the maternal 2-ME concentration and placental COMT expression in different trimesters normal pregnancy preeclamptic pregnancies, as well effects on cell proliferation migration HTR-8/SVneo under normoxic (20% O2) hypoxic (2.5% conditions. Methods: levels were examined ELISA. protein analyzed Western blot immunohistochemistry....
Background: To evaluate the clinical significance of degree pulmonary fissure completeness (PFC) on major in-hospital outcomes following video-assisted thoracoscopic (VATS) lobectomy for non-small-cell lung cancer (NSCLC). Materials and methods: We carried out a single-center retrospective analysis prospectively maintained database at our unit between August 2014 October 2015. Patients were divided into two groups based their sum average (FSA). with FSA >1 (1< ≤3) considered to have...
Preeclampsia is characterized by maternal endothelial dysfunction (e.g., increased vascular permeability caused the disassembly of junction proteins). However, it unclear if preeclampsia associated with impaired growth and expression proteins in human placentas. Herein, we examined placentas from women normal term (NT) preeclamptic (PE) pregnancies using two as markers: CD31 endothelial-cadherin (VE-Cad). We also compared protein mRNA VE-Cad between NT PE placentas, determined alternatively...
Trophoblast cell dysfunction is involved in many disorders during pregnancy such as preeclampsia and intrauterine growth restriction. Few treatments exist, however, that target improving trophoblast function. Human umbilical cord mesenchymal stem cells (hUCMSCs) are capable of self-renewing, can undergo multilineage differentiation, have homing abilities; addition, they immunomodulatory effects paracrine properties thus a prospective source for therapy. To identify whether hUCMSCs regulate...
Background: Previous studies demonstrated a significant association between the albumin-globulin ratio (AGR) and various types of cancers. The aim this study was to evaluate prognostic value preoperative AGR in patients with early-stage non-small cell lung cancer (NSCLC). Methods: Patients diagnosed as NSCLC single center January 1, 2014 February 29, 2016 were retrospectively reviewed. defined serum albumin level globulin level. Receiver operating characteristics analysis performed determine...
Abstract Background Uric acid/albumin ratio (UAR) is a novel composite biomarker with superior predictive value for cardiovascular disease. Objective To investigate the relationship between UAR and coronary collateral circulation (CCC) in patients non‐ST segment elevation myocardial infarction (NSTEMI). Methods A total of 205 NSTEMI who underwent arteriography at least one major stenosis, 95% were included. Patients divided into two groups according to CCC development: poorly‐developed group...