A5015736153- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Soil Carbon and Nitrogen Dynamics
- RNA modifications and cancer
- Bone health and treatments
- Cancer Cells and Metastasis
- Anesthesia and Sedative Agents
- Plant nutrient uptake and metabolism
- Cancer-related molecular mechanisms research
- Crop Yield and Soil Fertility
- Anesthesia and Neurotoxicity Research
- Polymer-Based Agricultural Enhancements
- Phytase and its Applications
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Mycotoxins in Agriculture and Food
- Neonatal Respiratory Health Research
- Plant-Microbe Interactions and Immunity
- Plant Growth Enhancement Techniques
- Plant Pathogens and Fungal Diseases
- Peatlands and Wetlands Ecology
- Nanoplatforms for cancer theranostics
- Soil and Water Nutrient Dynamics
- Neuroscience and Neuropharmacology Research
University of California, San Diego
2018-2025
Fujian Agriculture and Forestry University
2024-2025
Hefei Institutes of Physical Science
2018-2025
Chinese Academy of Sciences
2018-2025
Sun Yat-sen Memorial Hospital
2011-2024
University of Science and Technology of China
2018-2024
Sun Yat-sen University
2008-2024
Huazhong University of Science and Technology
2023
Shandong Normal University
2022
Rutgers, The State University of New Jersey
2021
Abstract Cancer-secreted, extracellular vesicle (EV)–encapsulated miRNAs enable cancer cells to communicate with each other and noncancerous in tumor pathogenesis response therapies. Here, we show that treatment a sublethal dose of chemotherapeutic agents induces breast secrete EV the capacity stimulate stem-like cell (CSC) phenotype, rendering resistance therapy. Chemotherapy induced multiple miRNAs, including miR-9-5p, miR-195-5p, miR-203a-3p, which simultaneously targeted transcription...
Abstract Breast cancer metastasis to the brain is a clinical challenge rising in prevalence. However, underlying mechanisms, especially how cells adapt distant niche facilitate colonization, remain poorly understood. A unique metabolic feature of coupling between neurons and astrocytes through glutamate, glutamine, lactate. Here we show that extracellular vesicles from breast with high potential develop metastases carry levels miR-199b-5p, which shows higher blood patients comparing those...
Extracellular vesicles (EVs) play important roles in cell-cell communication but are highly heterogeneous, and each vesicle has dimensions smaller than 200 nm with very limited amounts of cargos encapsulated. The technique NanOstirBar (NOB)-EnabLed Single Particle Analysis (NOBEL-SPA) reported the present work permits rapid inspection single EV high confidence by confocal fluorescence microscopy, thus enables colocalization assessment for selected protein microRNA (miRNA) markers EVs...
Introduction Plant physiology response and adaptation to drought stress has become a hotspot in plant ecology evolution. Cotoneaster multiflorus possesses high ecological, ornamental economic benefits. It large root system tolerance cold, poor soil. Therefore, C. is considered as one of the most important tree species for ecological restoration arid semi-arid areas. However, little known about physiological mechanisms, molecular mechanisms strategies how responds stress. exploring adaptive...
Bone is one of the most frequent metastatic sites advanced breast cancer. Current therapeutic agents aim to inhibit osteoclast-mediated bone resorption but only have palliative effects. During normal remodeling, balance between and osteoblast-mediated formation essential for homeostasis. One major function osteoblast during secrete type I procollagen, which will then be processed before being crosslinked deposited into matrix. Small RNA sequencing quantitative real-time PCR were used detect...
Arid and semi-arid regions are climate-sensitive areas, which account for about 40% of the world's land surface area. Future environment change will impact these area, resulting in a sharp expansion arid regions.
Hemorrhage-caused gene changes in the thalamus likely contribute to thalamic pain genesis. RNA N6-methyladenosine modification is an additional layer of regulation. Whether FTO (fat-mass and obesity-associated protein), demethylase, participates hemorrhage-induced unknown.Expression Fto mRNA protein was assessed mouse after hemorrhage caused by microinjection Coll IV (type collagenase) into unilateral thalamus. Effect intraperitoneal administration meclofenamic acid (a inhibitor) or...
Abstract Extracellular vesicles (EV) have emerged as critical effectors in the cross-talk between cancer and normal cells by transferring intracellular materials adjacent or distant cells. Previous studies begun to elucidate how cells, secreting EVs, adapt at a metastatic site facilitate cell metastasis. In this study, we utilized high-content microscopic screening platform investigate mechanisms of EV uptake primary lung fibroblasts. A selected library containing 90 FDA-approved anticancer...
We present vibrational sum-frequency generation (VSFG) microscopy as a new label-free chemical imaging technique for tumor identification. This method combines the chemical-bond selectivity of spectroscopy with coherent interference second-order nonlinear optics. Using fast line-scanning VSFG microscope, we obtained hyperspectral images collagen I from both lung tissues bearing metastatic tumors and in tumor-free ones, which reveal drastic different spectral signatures: samples exhibit large...
Crop rotation enhances soil fertility and health by modulating microbial communities, with organic carbon (SOC) dynamics governed aggregate–microbial interplay. To date, the effects of different crop rotations on SOC fractions relevant bacterial communities at aggregate scales remain uncertain. Here, a 17-year field experiment was used to reveal maize monoculture (MM), soybean (SS), communities. Compared SS treatment, only MS treatment significantly increased particulate (POC) content scale....
MR imaging (MRI) upon cell labeling is an attractive and clinically translatable tool for longitudinally monitoring the survival migration of stem cells. The common intracellular delivery superparamagnetic iron oxide nanoparticles (SPIONs) via poly-L-lysine (PLL) requires a high SPION concentration long incubation period appropriate labeling, which may negatively affect viability function In this study, we determined performance new class cationic polymersomes in transferring SPIONs into...
Synthetic nitrogen (N) fertilizer has made a great contribution to the improvement of soil fertility and productivity, but excessive application synthetic N may cause agroecosystem risks, such as acidification, groundwater contamination biodiversity reduction. Meanwhile, organic substitution received increasing attention for its ecologically environmentally friendly productivity benefits. However, linkages between manure substitution, crop yield underlying microbial mechanisms remain...
Oral tongue squamous cell carcinoma (OTSCC) is the most common subtype of oral cancer. A predictive gene signature necessary for prognosis OTSCC.Five microarray data sets OTSCC from Gene Expression Omnibus (GEO) and one set The Cancer Genome Atlas (TCGA) were obtained. Differentially expressed genes (DEGs) GEO identified by integrated analysis. DEGs associated with screened in TCGA univariate survival analysis to obtain a signature. risk score was calculated as summation weighted expression...