A5101985645- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Pelvic floor disorders treatments
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Urologic and reproductive health conditions
- Melanoma and MAPK Pathways
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Urinary Bladder and Prostate Research
- Hippo pathway signaling and YAP/TAZ
- Retinal Development and Disorders
- Cellular transport and secretion
- Genomics, phytochemicals, and oxidative stress
- Plant-derived Lignans Synthesis and Bioactivity
- Phagocytosis and Immune Regulation
- Plant-based Medicinal Research
- Advanced Glycation End Products research
- Bioactive Natural Diterpenoids Research
- FOXO transcription factor regulation
- Sesame and Sesamin Research
- Bladder and Urothelial Cancer Treatments
- Phytochemical and Pharmacological Studies
Minhang District Central Hospital
2018-2024
Fudan University
2020-2024
Eye & ENT Hospital of Fudan University
2023-2024
Wuhan Polytechnic University
2023
Zhongshan Hospital
2021-2022
Tongji University
2019-2021
Guangzhou Medical University
2021
University of California, San Diego
2018
First Affiliated Hospital of Fujian Medical University
2012-2013
Fujian Medical University
2012-2013
Abstract Acute myocardial infarction (AMI), the leading cause of mortality worldwide, is a rapidly developing and irreversible disease. Therefore, proper prompt intervention at early stage AMI crucial for its treatment. However, molecular features in have not been clarified. Here, we constructed mouse model profiled transcriptomes proteomes stages progress. Immune system was extensively activated 6-h AMI. Then, pyroptosis 24-h VX-765 treatment, inhibitor, significantly reduced infarct size...
Angiotensin II (AII) has been well known to induce cardiomyocyte hypertrophy. Epigallocatechin-3-gallate (EGCG) is the main active component of green tea and it shown exhibit strong cardioprotective potential, although underlying molecular mechanisms remain unclear. In this study, we investigated role mechanism EGCG in preventing AII-induced hypertrophy using rat H9c2 cardiomyocytes cells. Reactive oxygen species assay, cell size, mRNA expression cardiac markers ANP BNP were assessed...
Castration-resistant prostate cancer (CRPC), one of the cancers, is a medical conundrum around world. Some studies have demonstrated that many long noncoding RNAs in exosomes are very important types cancer, including cancer. However, until now, function occurrence and development CRPC has not been reported. In vitro, cell coculture was used LNCap cells PC-3 cells, while isolation purification subsequent treatment assays were functional studies. vitro performed to detect transformation ADPC...
Purpose. We aimed to investigate the changes of serum and cell exosome miR-205 levels in patients with prostate carcinoma its clinical significance. Materials Methods. Firstly, pronouncement normal tissues was analyzed by using UALCAN database. The relationship between tumor pathological characteristics were analyzed. Consequently, 60 people collected Minhang Hospital from August 2016 2021. Serum two groups collected, RNA exosomes extracted, qRT-PCR used analyze expression mediated exosomes....
Abstract Background Radical prostatectomy (RP) is the primary treatment of localized prostate cancer. Immediate urinary incontinence post-RP was still common and depressing without specific reason. Methods A multicenter cohort 154 consecutive patients from 2018 to 2020, who diagnosed with cancer underwent either modified mini-incision retropubic radical (Mmi-RRP) or laparoscopic (LRP) robotic-assisted (RARP). Seventy-two Denonvilliers’ fascia (DF) spared were included in DFS (Denonvilliers’...
To investigate the effects of magnesium isoglycyrrhizinate (MI) on changes phospholipase A2 (PLA2) induced during liver tissue injury following limb ischemia/reperfusion (I/R) in rats.Twenty-four healthy male Sprague-Dawley rats weighing (230+/-30) g were randomly divided into three groups (n = 8 each) as follows: control (Group C: anesthetization without any ischemia); I/R I/R: 4 h ischemia by rubber band ligation left hind around roots limb, followed 6 reperfusion, with 1 mL normal saline...
Seed germination is an important stage of growth and reproduction plays role in the life cycle spermatophyte. It co-determined by both genetic environmental factors, plant hormone regulation may be a highly conservative mechanism. Coix lachryrma-jobi (coix) grain with balanced nutrition for medicine food has substantial production value. part agricultural production, efficiency seed after sowing key link. In this study, coix species “small white shell Xingren” was used as experimental...
Hemophilia A and B are congenital bleeding disorders caused by a deficiency in pro-coagulant factor VIII or IX that is treated downregulation of antithrombin. However, the molecular mechanisms regulate antithrombin expression remain poorly understood. Here, we identified Cullin 2 USP2 (ubiquitin-specific peptidase-2) as novel regulators act modulating ubiquitination. Inhibition proteasome accumulation its ubiquitinated forms HepG2 SMMC7721 cells. Notably, inhibition neddylation with MLN4924...
Accumulating lines of evidence indicate that the deregulation m 6 A is involved in various cancer types. The RNA methylation modulated by methyltransferases, demethylases, and reader proteins. Although aberrant expression contributes to development progression multiple types, roles regulators across numerous types cancers remain largely unknown. Here, we comprehensively investigated expression, genetic alteration, prognosis significance 20 commonly studied diverse using TCGA datasets via...
To investigate the efficacy and safety of docetaxel chemotherapy combined with androgen-deprivation therapy for patients high-volume disease metastatic hormone-sensitive prostate cancer.153 cases cancer in Minhang Hospital between January 2018 December 2019 were analyzed retrospectively, including number patients, age, initial PSA level, Gleason score, TNM stage ECOG score. 90 endocrine group received continuous ADT, 63 plus ADT. The progression-free survival time (time from initiation...
Elliptic curve cryptography (ECC) is widely used in security applications such as public key (PKC) and zero-knowledge proofs (ZKP). ECC composed of modular arithmetic, where multiplication takes most the processing time. Computational complexity memory constraints limit performance. Therefore, hardware acceleration on an active field research. Processing-in-memory (PIM) a promising approach to tackle this problem. In work, we design ModSRAM, first 8T SRAM PIM architecture compute...
Abstract Background Retroperitoneal partial nephrectomy (RLPN) is the premier treatment for localized renal tumors despite narrow operation space. Many efforts have been taken to facilitate of RLPN, but optimal resolution remains debatable. Objective To explore feasibility using Mini‐lap improve workspace and surgical vision in RLPN. Design, Setting, Participants A multicenter retrospective review 51 patients who underwent RLPN with from January 2018 December 2020 was conducted. Surgical...
This study aimed to explore the role of circ-ITCH in progression bladder cancer (BCa). Kaplan-Meier analysis was performed evaluate prognostic significance miR-184 cancer. Clustering compared expression levels across various BCa cell lines. Cell Counting Kit-8 (CCK-8) and transwell assays were used assess proliferation migration. Dual-luciferase reporter employed examine regulatory relationship among circ-ITCH, miR-184, FOXO3. Western blot conducted investigate post-transcriptional...
1. Intramuscular fat (IMF) is a key parameter for chicken meat quality. IMF deposition driven by genetic, nutritional and management factors, with genetics being the determining factor. Previous whole transcriptome sequencing revealed that microRNA gga-let-7a-3p was related to lipid metabolism in breast muscle. This study further investigated potential role of deposition.
Melanoma, the most threatening cancer in skin, has been considered to be driven by carcinogenic RAF-MEK1/2-ERK1/2 signaling pathway. This pathway is usually mainly dysregulated mutations BRAF or RAS skin melanomas. Although inhibitors targeting mutant BRAF, such as vemurafenib, have improved clinical outcome of melanoma patients with mutations, efficiency vemurafenib limited many patients. Here, we show that blood bilirubin BRAF-mutant treated negatively correlated outcomes. In vitro and...
Prostate cancer (PCa) is considered the most serious in world. Nevertheless, accuracy of current biomarkers, such as pathological staging, Gleason's score, and serum prostate-specific antigen (PSA) levels, limited. FOXO1 a key downstream effector PTEN tumor suppressor PCA, which has been reported extensively. However, clinical relevance PCa remains unclear.In this study, we first detected its expression four public databases to explore role FOXO1. Verification knockdown effect siRNA was...
Objective To explore the significance of prostate central gland to total volume ratio (PVc/PV) in diagnosis cancer (PCa) patients with specific antigen (PSA) levels grey zone (4–10 ng/ml). Methods This retrospective study enrolled that had undergone biopsy. The and were measured. differences PSA, free PSA (f/tPSA), density (PSAD) PVc/PV between PCa non-PCa groups compared. Receiver operating characteristic curve analysis for clinically significant (csPCa) calculated according (reference),...