A5020678508- Psoriasis: Treatment and Pathogenesis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Dermatology and Skin Diseases
- Cancer-related gene regulation
- Vitamin C and Antioxidants Research
- Pharmaceutical studies and practices
- Flavonoids in Medical Research
- Inflammatory mediators and NSAID effects
- Inflammatory Biomarkers in Disease Prognosis
- NF-κB Signaling Pathways
- Protein Degradation and Inhibitors
- Traditional Chinese Medicine Analysis
- Galectins and Cancer Biology
- Autoimmune and Inflammatory Disorders Research
- Long-Term Effects of COVID-19
- Peroxisome Proliferator-Activated Receptors
- Hematological disorders and diagnostics
- Endoplasmic Reticulum Stress and Disease
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Ion Channels and Receptors
- interferon and immune responses
- Allergic Rhinitis and Sensitization
- Liver Disease Diagnosis and Treatment
Tongji University
2020-2024
Shanghai Skin Disease Hospital
2023-2024
Anhui Medical University
2024
Shanghai Tenth People's Hospital
2022
Background Psoriasis is a chronic inflammatory skin disease with effects that extend beyond the skin. Insulin resistance (IR) has been associated psoriasis, but it remains unclear how indicators related to triglyceride glucose (TyG) index, which were associate IR, are condition. Objective The purpose of this study was investigate association between psoriasis and three TyG-related indicators: glucose-body mass index (TyG-BMI), glucose-waist height ratio (TyG-WHtR), circumference (TyG-WC)....
Abstract Background Psoriasis and insulin resistance (IR) are closely related, but it remains unclear whether IR affects the treatment of patients with psoriasis. Objective To investigate impairs response to biologic agents in moderate-to-severe plaque Methods This project was based on a prospective cohort study design. Data were collected from Shanghai Effectiveness Evaluation CoHort (SPEECH), which is exploring strategies for psoriasis China. assessed using triglyceride glucose–body mass...
BackgroundAlthough clinical trials and real-world data suggest that the risk of COVID-19 its complications is not exacerbated in patients with psoriasis treated by biological agents, evidence for this still limited.ObjectivesWe aimed to assess outcomes among Chinese IL-23 inhibitor, compare these variables receiving other therapies.MethodsA cross-sectional cohort study was conducted treatment inhibitor methods. All received a questionnaire contained questions about their treatment, symptoms,...
Abstract Background Treatment responses to biologic agents vary between patients with moderate severe psoriasis; while some achieve total skin clearance (TSC), a proportion of may only experience partial improvement. Objective This study was designed identify potential predictors for achieving TSC in psoriasis treated IL-17 inhibitors. It also aimed develop an easy-to-use calculator incorporating these factors by the nomogram predict response. Methods A 381 receiving ixekizumab were included...
Transmembrane emp24 domain containing (TMED) proteins are known to play pivotal roles in normal development, but have been reported be implicated pancreatic disease, immune system disorders, and cancers. As far as TMED3 is concerned, its cancers controversial. However, evidence describing the context of malignant melanoma (MM) scarce.In this study, we characterized functional significance MM identified a tumor-promoting factor development. Depletion arrested development vitro vivo....
Background The transient receptor potential vanilloid (TRPV) channels family, TRPV1-6, has been identified to profoundly affect a wide spectrum of pathological processes in various cancers. However, the biological function and prognostic value TRPVs clear cell renal carcinoma (ccRCC) are still largely unknown. Methods We obtained gene expression data clinical information 539 ccRCC patients from Cancer Genome Atlas (TCGA) database. A series databases were used for processing visualization,...
Abstract Lung cancer is the leading cause of cancer‐related death worldwide. Previous studies revealed that endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) played critical roles in malignant behaviors several types, but its role non‐small cell lung (NSCLC) remained unclear. In this study, we identified 26 upregulated and 102 downregulated genes NSCLC using bioinformatics analyses, these were enriched biological processes cycle. ERO1L was remarkably overexpression associated with poor...
Background Fatty liver disease (FLD) is a common comorbidity of psoriasis and often referred to as non-alcoholic fatty (NAFLD). However, the role inflammation or insulin resistance (IR) in FLD inconclusive. The study aims explore whether patients more related systemic level. Methods Data for this were collected from Shanghai Psoriasis Effectiveness Evaluation Cohort, prospective cohort that examines characteristics Chinese population. IR was assessed using triglyceride glucose (TyG) TyG-body...
ABSTRACT Psoriasis exhibits a higher incidence of anxiety and depression. However, the diagnostic process heavily relies on subjective evaluation. Fatty acid‐binding protein 7 (FABP7) serotonin (5‐HT) are considered as potential plasma biomarkers. We aimed to investigate potentiality FABP7 5‐HT biomarkers for predicting depression in psoriasis. Data were analysed from 140 patients with psoriasis Shanghai Effectiveness Evaluation CoHort (SPEECH). Unsupervised clustering was employed group...
Accumulating lines of evidence indicate that the deregulation m 6 A is involved in various cancer types. The RNA methylation modulated by methyltransferases, demethylases, and reader proteins. Although aberrant expression contributes to development progression multiple types, roles regulators across numerous types cancers remain largely unknown. Here, we comprehensively investigated expression, genetic alteration, prognosis significance 20 commonly studied diverse using TCGA datasets via...
Background . Occult psoriatic arthritis (PsA) refers to a subset of psoriasis patients showing lesions on imaging but do not exhibit symptoms. Objective This study was aimed discover simple biomarker that could be easily incorporated in clinical practice identify occult PsA patients, defined as with without symptoms, among silent (PsO) any Methods A total 149 PsO including 83 alone symptoms and evidence imaging, 66 were enrolled this cross‐sectional study, they all underwent blood tests...