A5112564347- Bacterial Genetics and Biotechnology
- DNA Repair Mechanisms
- Optical Network Technologies
- Pelvic floor disorders treatments
- PARP inhibition in cancer therapy
- Esophageal and GI Pathology
- Advanced Photonic Communication Systems
- Lung Cancer Research Studies
- Pediatric Urology and Nephrology Studies
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Gene Regulatory Network Analysis
- CRISPR and Genetic Engineering
- Optical Wireless Communication Technologies
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
- Microbial Metabolic Engineering and Bioproduction
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Abdominal vascular conditions and treatments
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
Zhejiang University
2008-2025
Sir Run Run Shaw Hospital
2020-2025
Shanghai Municipal Commission of Health and Family Planning
2024
Fudan University
2010-2024
Second People Hospital of Hunan
2024
Minhang District Central Hospital
2021-2024
Jilin University
2023-2024
First Hospital of Jilin University
2023-2024
Nanchang University
2018-2024
Third Affiliated Hospital of Nanchang University
2018-2024
Diabetic cardiomyopathy (DCM) is a prevalent myocardial microvascular complication of the myocardium with complex pathogenesis. Investigating pathogenesis DCM can significantly contribute to enhancing its prevention and treatment strategies. Our study revealed an upregulation lysine acetyltransferase 2 A (Kat2a) expression in DCM, accompanied by decrease N6-methyladenosine (m6A) modified Kat2a mRNA levels. Functionally, inhibition effectively ameliorated high glucose-induced cardiomyocyte...
Mathematical modelling is central to systems and synthetic biology. Using simulations calculate statistics or explore parameter space a common means for analysing these models can be computationally intensive. However, in many cases, the are easily parallelizable. Graphics processing units (GPUs) capable of efficiently running highly parallel programs outperform CPUs terms raw computing power. Despite their computational advantages, adoption by biology community relatively slow, since...
Here we introduce a new design framework for synthetic biology that exploits the advantages of Bayesian model selection. We will argue difference between inference and is in former try to reconstruct system has given rise data observe, whereas latter, seek construct produces would like i.e., desired behavior. Our approach allows us exploit methods from statistics, including efficient exploration models spaces high-dimensional parameter spaces, ability rank with respect their generate certain...
Abstract Objective The aim of this study is to investigate the factors influencing recurrence diabetic foot ulcers (DFU) and provide guidance for reducing rate. Methods A total 211 patients diagnosed with DFU who were hospitalized discharged from hospital October 2015 January 2020 included as cohort. Participants divided into two groups according whether ulcer recurred during 2‐year follow‐up period: a group ( n = 84) non‐recurrence 127). following data collected analyzed patients: general...
Intrahepatic cholangiocarcinoma (iCCA) can originate from the large bile duct group (segment ducts and area ducts), small (septal interlobular terminal (bile ductules canals of Hering) intrahepatic biliary tree, which be histopathological corresponding to type iCCA, iCCA with ductal plate malformation pattern, cholangiolocarcinoma, respectively. The challenge in pathological diagnosis above subtypes falls distinction cellular morphologies, tissue structures, growth patterns, invasive...
BACKGROUND The expression pattern of gamma aminobutyric acid (GABA) receptor subunits are commonly altered in patients with schizophrenia, which may lead to nerve excitation/inhibition problems, affecting cognition, emotion, and behavior. AIM To explore GABA its relationship schizophrenia provide insights into more effective treatments. METHODS This case-control study enrolled 126 treated at our hospital healthy volunteers who underwent physical examinations during the same period. levels...
Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive type of with poor prognosis high recurrence rate. Chemotherapy still the mainstay treatment for patients without genetic BRCA mutation, despite approval Olaparib, an inhibitor poly (ADP-ribose) polymerase (PARP) enzyme. Tripartite motif containing-21 (TRIM21) one TRIM family members that has been investigated in various types cancer. Here, we found low TRIM21 expression level was correlated overall survival TNBC patients....
Background/Aims: Aquaporin-3 (AQP3), one isoform of water channel family, has been found to be expressed in mouse oocytes. The present study aimed investigate whether functional AQP3 was oocytes induced by controlled ovarian hyperstimulation (COH), and altered oocyte expression associated with changes fertilization rate. Methods: Sixty ICR female mice were divided into two groups: COH control. mRNA metaphase II (MII) quantified real-time RT-PCR. permeability assessed cell swelling test....
To prospectively investigate the clinical efficacy of using diffuse optical tomography (DOT) and ultrasonographic (US) localization with conventional US to differentiate malignant solid breast lesions from those that are benign.The study was approved by institutional review board all patients provided written informed consent. One hundred two consecutive women (mean age, 43 years; range, 18-86 years) who were referred for open biopsy 136 underwent DOT localization. Total hemoglobin...
Increasing evidence highlights that fibroblast growth factor receptor 2 (FGFR2) fusion/rearrangement shows important therapeutic value for patients with intrahepatic cholangiocarcinoma (ICC). This study aims to explore the association of FGFR2 status prognosis and immune cell infiltration profiles ICC. A total 226 ICC tissue samples from who received surgery at Department Liver Surgery Zhongshan Hospital, Fudan University, were collected retrospectively assigned a primary cohort (n = 152)...
The objective of this study is to form a cancer stem cell index-based model stratify HCC risk and predict survival. After screening the Tumor Genome Atlas (TCGA) liver normal tissue samples, we obtained differentially expressed genes (DEGs). We employed weighted correlation network analysis (WGCNA) were studied in find modules most associated with cells (mRNAsi). At same time, gene ontology Kyoto Encyclopedia (KEGG) used for functional annotation combined LASSO, univariate, multivariate COX...
Objective To investigate the relationship between inflammatory factors, oxidative stress and type 1 deiodinase (DIO-1) concentration in patients with chronic renal failure (CRF) or without euthyroid sick syndrome (ESS). Methods This study recruited CRF divided them into two groups: group had low free triiodothyronine (FT3) levels; 2 normal FT3 levels. Group 3 consisted of healthy volunteers. Serum levels interleukin (IL)-6, IL-1β, tumour necrosis factor (TNF)-α, 8-isoprostane DIO-1 were...
Abstract Background The trends in usage of tumor markers, including CEA, SCC, NSE, Cyfra21‐1, and ProGRP, Chinese lung cancer patients the real‐world setting are not fully investigated. Methods A retrospective descriptive study was conducted using database Qilu Hospital Shandong University, China between January 2013 December 2017, involving primarily diagnosed with NSCLC or SCLC. Utilization by first discharge year, utilization rates within different durations before after date, combined...
Abstract Background Radical prostatectomy (RP) is the primary treatment of localized prostate cancer. Immediate urinary incontinence post-RP was still common and depressing without specific reason. Methods A multicenter cohort 154 consecutive patients from 2018 to 2020, who diagnosed with cancer underwent either modified mini-incision retropubic radical (Mmi-RRP) or laparoscopic (LRP) robotic-assisted (RARP). Seventy-two Denonvilliers’ fascia (DF) spared were included in DFS (Denonvilliers’...
Two-component systems play a central part in bacterial signal transduction. Phosphorelay mechanisms have been linked to more robust and ultra-sensitive signalling dynamics. The molecular machinery that facilitates such is, however, only understood outline. In particular the functional relevance of dimerization non-orthodox or hybrid histidine kinase along which phosphorelay takes place has subject debate. We use combination genetic approaches, coupled mathematical statistical modelling,...