A5052957872- Pharmacology and Obesity Treatment
- Metabolism, Diabetes, and Cancer
- Erythrocyte Function and Pathophysiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Thyroid Disorders and Treatments
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Growth Hormone and Insulin-like Growth Factors
- Advanced Glycation End Products research
- Neuroscience of respiration and sleep
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Function and Risk Factors
- High Altitude and Hypoxia
- Cardiovascular Disease and Adiposity
- Epigenetics and DNA Methylation
- Coronary Interventions and Diagnostics
- Mesenchymal stem cell research
- Chromatography in Natural Products
- MicroRNA in disease regulation
- Fibroblast Growth Factor Research
- Diabetes Treatment and Management
- Tissue Engineering and Regenerative Medicine
- Cancer, Hypoxia, and Metabolism
- Acute Kidney Injury Research
Southern Medical University
2021-2024
Nanchang University
2012-2018
Third Affiliated Hospital of Nanchang University
2018
Second Affiliated Hospital of Nanchang University
2012-2014
Second Hospital of Nanchang
2011
Abstract Cardiac autonomic neuropathy in Type 2 diabetes (T2D) is often a devastating complication. Long non‐coding RNAs (lncRNAs) have important effects on both normal development and disease pathogenesis. In this study, we explored the expression profiles of some lncRNAs involved inflammation which may be co‐expressed with messenger RNA (mRNA) superior cervical stellate ganglia after type diabetic injuries. Total isolated from 10 pairs male rats was hybridized to lncRNA arrays for...
It is unclear to what extent uremic toxins participate in inflammatory responses and the activities of deiodinases, as well effects deiodinases on cytokines. Hepatocellular carcinoma cell lines (HepG2) were transfected with small interfering ribonucleic acid (siRNA) specific for deiodinase type 1 (DIO1) cultured or without toxins. The mRNA expression DIO1, interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α was detected by quantitative real-time PCR. presence selenoprotein M (SelM) DIO1...
Objective To investigate the relationship between inflammatory factors, oxidative stress and type 1 deiodinase (DIO-1) concentration in patients with chronic renal failure (CRF) or without euthyroid sick syndrome (ESS). Methods This study recruited CRF divided them into two groups: group had low free triiodothyronine (FT3) levels; 2 normal FT3 levels. Group 3 consisted of healthy volunteers. Serum levels interleukin (IL)-6, IL-1β, tumour necrosis factor (TNF)-α, 8-isoprostane DIO-1 were...
This study was aimed at exploring the effects of P2X7 receptors on gp120-induced injury and naringin's protective against in BV2 microglia. microglia model established by gp120 treatment MTS assay used to verify whether naringin has a cell-protective effect injury. Changes receptor expression were assayed using RT-PCR, qPCR, western blot. Results showed that ODs Ctrl, gp120, gp120+naringin, gp120+BBG groups 0.91 ± 0.10, 0.71 0.09, 0.83 respectively. Compared control group, group...
Endosulfan is an organochlorine pesticide, which poses a potential danger to human health and safety. It known that dysfunction of glomerular mesangial cells causes sclerosis, associated with chronic kidney diseases. In the present study, we investigated effects endosulfan on cell proliferation extracellular matrix accumulation (ECM) in renal (HRMCs). Cells were treated endosulfan, (10 μM) plus specific inhibitor TGF-β signaling (LY2109761) or antioxidant (NAC). The results showed...
<title>Abstract</title> <bold>Objective:</bold> The apoptosis of glomerular mesangial cells is closely related to the occurrence and development diabetic nephropathy (DN). However, mechanism remains unclear. In present study, we found that high-glucose cultures induced upregulation miRNA-302c-3p. This study aimed investigate effects over expression miR-302c-3p on human (HRMCs). <bold>Materials Methods: </bold>HRMCs were cultured in vitro divided into 2 groups: ①: siRNA-NC group, ②...
The Original article is published with an error in Table.
<b><i>Background/Aims:</i></b> Chronic renal failure (CRF) is often accompanied by increased oxidative stress and euthyroid sick syndrome (ESS). The cause of ESS unknown, it unknown whether there exists a link between oxidant in CRF patients. Therefore, we aim to investigate type 1 deiodinase (DIO1) expression, which plays the key role <b><i>Methods:</i></b> In-patients with were divided into two group: Group patients consisting 60 low free...