Prostate cancer (PCa) is a devastating malignant disease with poor prognosis. The aim of current study to investigate the role lncRNA-urothelial carcinoma associated 1 (UCA1) in progression PCa. We evaluated expression levels UCA1 total 16 benign prostatic hyperplasia tissues (BPH) and 40 PCa tissues, as well cells. functional regulatory effects were investigated using series cell function approaches. Our data showed that frequently overexpressed compared BPH (P<0.01). Moreover, higher was...

Purpose: To investigate the therapeutic effect of transcutaneous electrical nerve stimulation (TENS) on poststroke urinary incontinence (UI). Patients and methods: Sixty-one patients with UI were enrolled at Neurology Department in Shanghai Tenth People's Hospital Tongji University between January 2010–January 2011 divided into treatment control groups (n=32 n=29, respectively). TENS was applied to group, while group received basic therapy. The completed whole set therapy a frequency 30...

Abstract Increasing evidence demonstrated that noncoding RNAs (lncRNA, miRNA) play important roles in the cancer development. LncRNA NEAT1 functions as an oncogene many cancers. However, of prostate (PCa) remain largely unknown. In present study, we aim to explore molecular mechanism development PCa. We detected expression levels a total 16 benign prostatic hyperplasia tissues (BPH), 30 matched adjacent healthy control (HC) and PCa tissues, well cell lines PC-3, DU-145, LNCaP normal...

MicroRNAs play a crucial role in cancer progression and metastasis. miR-203a has been identified as tumor suppressor various cancers. However, its functions renal cell carcinoma have not illustrated. In this study, we detected the expression evaluated association with clinical features. Overexpression of was found tissues cells. High is correlated stage short overall survival time. Bioinformatics luciferase assay confirmed that glycogen synthase kinase-3β target gene miR-203a. Silencing...

Bladder cancer (BC) is the most common urinary system malignancy worldwide.However, molecular mechanisms underlying its progression remain largely unexplored.Accumulating evidence indicates that cancer-associated fibroblasts (CAFs), major constituents of tumor stroma, play a key role in development.Herein, we have successfully isolated CAFs and paired normal (NFs) from bladder tissues.We observed conditional medium (CM-CAF) could significantly enhance cell proliferation (p<0.01) invasion...

To explore the efficacy and safety of immunoneoadjuvant therapy with pembrolizumab combined chemotherapy in locally advanced resectable hypopharyngeal squamous cell carcinoma patients.

Castration-resistant prostate cancer (CRPC), one of the cancers, is a medical conundrum around world. Some studies have demonstrated that many long noncoding RNAs in exosomes are very important types cancer, including cancer. However, until now, function occurrence and development CRPC has not been reported. In vitro, cell coculture was used LNCap cells PC-3 cells, while isolation purification subsequent treatment assays were functional studies. vitro performed to detect transformation ADPC...

Objective. The aim of this study was to evaluate the outcome and determine complications ultrasound-guided 16 F tract percutaneous nephrolithotomy (PCNL) by review over 1000 cases in a Chinese hospital. Material methods. A total 1368 patients underwent PCNL hospital between March 2007 July 2013. Surgery performed under general anesthesia all cases. Central venous puncture chosen as device. Complications, residual stones, stone clearance need for auxiliary treatments were evaluated....

Purpose. We aimed to investigate the changes of serum and cell exosome miR-205 levels in patients with prostate carcinoma its clinical significance. Materials Methods. Firstly, pronouncement normal tissues was analyzed by using UALCAN database. The relationship between tumor pathological characteristics were analyzed. Consequently, 60 people collected Minhang Hospital from August 2016 2021. Serum two groups collected, RNA exosomes extracted, qRT-PCR used analyze expression mediated exosomes....

Abstract Background Radical prostatectomy (RP) is the primary treatment of localized prostate cancer. Immediate urinary incontinence post-RP was still common and depressing without specific reason. Methods A multicenter cohort 154 consecutive patients from 2018 to 2020, who diagnosed with cancer underwent either modified mini-incision retropubic radical (Mmi-RRP) or laparoscopic (LRP) robotic-assisted (RARP). Seventy-two Denonvilliers’ fascia (DF) spared were included in DFS (Denonvilliers’...

A 53-year-old man presented to our department with acute urinary retention and an approximate 8-year history of frequent urination, dysuria, poor stream nocturia. His prostate-specific antigen (PSA) values were normal (<4 ng/ml) upon repeated testing. The patient was diagnosed benign prostatic hyperplasia, although there no significant improvement in his symptoms after treatment oral finasteride doxazosin. He then underwent transurethral resection the prostate February 2013,...

To investigate the efficacy and safety of docetaxel chemotherapy combined with androgen-deprivation therapy for patients high-volume disease metastatic hormone-sensitive prostate cancer.153 cases cancer in Minhang Hospital between January 2018 December 2019 were analyzed retrospectively, including number patients, age, initial PSA level, Gleason score, TNM stage ECOG score. 90 endocrine group received continuous ADT, 63 plus ADT. The progression-free survival time (time from initiation...

This study aimed to explore the role of circ-ITCH in progression bladder cancer (BCa). Kaplan-Meier analysis was performed evaluate prognostic significance miR-184 cancer. Clustering compared expression levels across various BCa cell lines. Cell Counting Kit-8 (CCK-8) and transwell assays were used assess proliferation migration. Dual-luciferase reporter employed examine regulatory relationship among circ-ITCH, miR-184, FOXO3. Western blot conducted investigate post-transcriptional...

Objective: To explore the significance of prostate central gland/total gland volume (PVc/PV) ratio combined with PSA in diagnosis 4-20 ng/ml cancer patients. Methods: Data patients undergoing puncture Minghang Branch, Zhongshan Hospital from July 2015 to December 2018 were retrospectively analyzed. The anteroposterior, transverse and axial diameters measured by magnetic resonance imaging (MRI). differences tPSA, f/tPSA, PSAD PVc/PV between group non-prostate compared. Receiver operating...

Abstract Background Retroperitoneal partial nephrectomy (RLPN) is the premier treatment for localized renal tumors despite narrow operation space. Many efforts have been taken to facilitate of RLPN, but optimal resolution remains debatable. Objective To explore feasibility using Mini‐lap improve workspace and surgical vision in RLPN. Design, Setting, Participants A multicenter retrospective review 51 patients who underwent RLPN with from January 2018 December 2020 was conducted. Surgical...

Objective: To systematically evaluate the quality of clinical practice guidelines for diagnosis and treatment benign prostatic hyperplasia (BPH), to compare context recommendations in order provide references application. Methods: We searched databases such as National Guideline Clearinghouse (NGC), Guidelines International Network (GIN), Institute Health Clinical Excellence (NICE), Scottish Intercollegiate (SIGN) World Organization (WHO), PubMed, Embase, CNKI, VIP, WanFang Data, CBM,...

Objective To explore the significance of prostate central gland to total volume ratio (PVc/PV) in diagnosis cancer (PCa) patients with specific antigen (PSA) levels grey zone (4–10 ng/ml). Methods This retrospective study enrolled that had undergone biopsy. The and were measured. differences PSA, free PSA (f/tPSA), density (PSAD) PVc/PV between PCa non-PCa groups compared. Receiver operating characteristic curve analysis for clinically significant (csPCa) calculated according (reference),...

Abstract Background: Radical prostatectomy (RP) is the primary treatment of localized prostate cancer. Immediate urinary incontinence post-RP was still common and depressing without specific reason. Methods: A multicenter cohort 154 consecutive patients from 2018 to 2020, who diagnosed with cancer underwent either modified mini-incision retropubic radical (Mmi-RRP) or laparoscopic (LRP) robotic-assisted (RARP). Seventy-two DF spared were included in DFS group. Whereas eighty-two completely...