A5006366921- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Pelvic floor disorders treatments
- Multiple and Secondary Primary Cancers
- Radiomics and Machine Learning in Medical Imaging
- Experimental Behavioral Economics Studies
- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Cancer Genomics and Diagnostics
- Auction Theory and Applications
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Treatment and Research
- Groundwater flow and contamination studies
- Groundwater and Isotope Geochemistry
- Galectins and Cancer Biology
- Enzyme Structure and Function
- Chemical Reactions and Isotopes
- Groundwater and Watershed Analysis
- Anorectal Disease Treatments and Outcomes
- Game Theory and Applications
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Zhongshan Hospital
2020-2024
Fudan University
2020-2024
Sun Yat-sen University
2020-2024
Obstetrics and Gynecology Hospital of Fudan University
2022
Shanghai Xuhui Central Hospital
2022
PowerChina (China)
2019
Wuhan University
2014
Abstract Background Checkpoint inhibitor immunotherapy plus tyrosine kinase (IO/TKI) have been recently recommended as standard first-line therapy for advanced renal cell carcinoma, while no clinical-available biomarker has applied. This study aimed to investigate the associations between RUNX3 pathway signature and IO/TKI benefits in carcinoma (RCC). Methods Two cohorts (ZS-MRCC, JAVELIN-101) one high-risk localized RCC cohort (ZS-HRRCC) were included. All samples evaluated by...
Abstract Background Immunotherapy (IO) plus tyrosine kinase inhibitor (TKI) emerged as standard first‐line therapy for advanced renal cell carcinoma (RCC). The heme Oxygenase 1 (HMOX1) pathway is involved in tumor development and treatment resistance, which may affect the efficacy of TKI + IO. Methods Two cohorts from our center (ZS‐MRCC, ZS‐HRRCC), one cohort clinical trial (JAVELIN Renal 101) Cancer Genome Atlas (TCGA‐KIRC) were enrolled. HMOX1 signatures determined each sample by...
Abstract The accurate understanding of groundwater circulation pattern and its renewable capacity is vital for resource assessment the rational exploitation utilization groundwater. Estimation recharge difficult in arid or semiarid area due to low amount variability recharge. A combination isotope investigation with hybrid model allows a direct calculation renewability aquifer. In this paper, phreatic water Yinchuan Basin, located at northwest China, are investigated by application...
Abstract Background In renal cell carcinoma (RCC), no clinically available biomarker has been utilized for checkpoint inhibitor immunotherapy (IO) + tyrosine kinase (TKI) combinations. Galectin‐1 overexpression is found in tumors, with potential immune‐regulating roles. Methods RNA‐sequencing was performed two cohorts of RCC treated IO/TKI combination therapy (ZS‐MRCC, JAVELIN‐101). Immunohistochemistry and flow cytometry were to investigate immune infiltration function the tumor...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Abstract Background Radical prostatectomy (RP) is the primary treatment of localized prostate cancer. Immediate urinary incontinence post-RP was still common and depressing without specific reason. Methods A multicenter cohort 154 consecutive patients from 2018 to 2020, who diagnosed with cancer underwent either modified mini-incision retropubic radical (Mmi-RRP) or laparoscopic (LRP) robotic-assisted (RARP). Seventy-two Denonvilliers’ fascia (DF) spared were included in DFS (Denonvilliers’...
Checkpoint inhibitor immunotherapy plus tyrosine kinase (IO/TKI) has become the first-line treatment for metastatic renal cell carcinoma (RCC), despite lack of biomarkers. Cyclin-dependent 6 (CDK6) shown a regulatory role in antitumour response. The study enrolled two cohorts RCC treated by IO/TKI (Zhongshan Hospital [ZS]-MRCC, n = 45; JAVELIN-101, 726) and localized (ZS-HRRCC, 40; TCGA-KIRC, 530). CDK6 was evaluated RNA-sequencing. Progression-free survival (PFS) primary endpoint....
To explore the predictive value of renal tumor contour irregular degree (CID) in pathological T3a upstaging clinical T1 cell carcinoma (RCC). We performed a retrospective multi-institutional review 1,487 patients with T1N0M0 RCC between January 2009 and June 2019. Kaplan-Meier survival curve Cox regressions were used to analyze prognostic factors disease-free (DFS). Logistic determine predictors RCC. Among cT1 RCC, 96 (6.5%) upstaging. Multivariable logistic regression analysis showed that...
We aimed to discover prognostic factors of muscle-invasive bladder cancer (MIBC) and investigate their relationship with immune therapies. Online data MIBC were obtained from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus database (GEO) database. Weighted gene co-expression network analysis (WGCNA) univariate Cox applied classify genes into different groups. Venn diagram was used find the intersection genes, efficacy proved by Kaplan-Meier analysis. Heatmap utilized for differential...
Abstract Background Retroperitoneal partial nephrectomy (RLPN) is the premier treatment for localized renal tumors despite narrow operation space. Many efforts have been taken to facilitate of RLPN, but optimal resolution remains debatable. Objective To explore feasibility using Mini‐lap improve workspace and surgical vision in RLPN. Design, Setting, Participants A multicenter retrospective review 51 patients who underwent RLPN with from January 2018 December 2020 was conducted. Surgical...
To assess the impact of malignant cystic renal masses (CRM) rupture on oncologic outcomes.The study included 406 cases with partial nephrectomy (PN) and 17 cyst decortication confirmed as CRM by pathology. Recurrence-free survival (RFS), metastasis-free (MFS), cancer-specific (CSS), overall (OS) were analyzed Kaplan-Meier method log-rank test. Cox regression was used to identify risk factors associated RFS, MFS, CSS, OS. Logistic performed explore predictors rupture.Tumor occurred in 32...
Abstract Background: Radical prostatectomy (RP) is the primary treatment of localized prostate cancer. Immediate urinary incontinence post-RP was still common and depressing without specific reason. Methods: A multicenter cohort 154 consecutive patients from 2018 to 2020, who diagnosed with cancer underwent either modified mini-incision retropubic radical (Mmi-RRP) or laparoscopic (LRP) robotic-assisted (RARP). Seventy-two DF spared were included in DFS group. Whereas eighty-two completely...
Benign prostatic hyperplasia (BPH) significantly reduces the quality of life. However, biological mechanisms BPH development remain largely unknown. We aimed to investigate essential genomic and immunogenic features in BPH.Transcriptome profiling clinical data normal prostate samples were acquired from GEO datasets. The discovery sets composed GSE119195, GSE7307, GSE101486, while validation set was GSE132714. ESTIMATE CIBERSORT used features. Furthermore, transcriptional weighted gene...