A5101668124- Photochromic and Fluorescence Chemistry
- Crystal structures of chemical compounds
- RNA modifications and cancer
- Porphyrin and Phthalocyanine Chemistry
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Organoselenium and organotellurium chemistry
- Autophagy in Disease and Therapy
- Silkworms and Sericulture Research
- Photoreceptor and optogenetics research
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Organometallic Compounds Synthesis and Characterization
- Phagocytosis and Immune Regulation
- Hemiptera Insect Studies
- Invertebrate Immune Response Mechanisms
- Synthesis of Indole Derivatives
- Free Radicals and Antioxidants
- Supramolecular Self-Assembly in Materials
- Photoacoustic and Ultrasonic Imaging
- Viral Infectious Diseases and Gene Expression in Insects
- Inflammasome and immune disorders
- Gastric Cancer Management and Outcomes
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
Tongji University
2019-2024
Tongji Hospital
2019-2024
Fujian Medical University
2018-2024
Shanghai First Maternity and Infant Hospital
2023
Southern Medical University
2018
Nanfang Hospital
2018
Fujian Provincial Cancer Hospital
2018
Wuhan University
2017
Central China Normal University
2006-2016
Southeast University
2012
Abstract Acute myocardial infarction (AMI), the leading cause of mortality worldwide, is a rapidly developing and irreversible disease. Therefore, proper prompt intervention at early stage AMI crucial for its treatment. However, molecular features in have not been clarified. Here, we constructed mouse model profiled transcriptomes proteomes stages progress. Immune system was extensively activated 6-h AMI. Then, pyroptosis 24-h VX-765 treatment, inhibitor, significantly reduced infarct size...
Abstract Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits development OXPHOS‐targeting treatment. Here, lines sensitive or resistant OXPHOS are identified by screening. inhibition‐sensitive cells possess increased activity and silenced nicotinamide N ‐methyltransferase (NNMT) expression. NNMT expression negatively correlates with functionally downregulates intracellular levels S‐adenosyl...
5-methylcytosine (m5C) is an important epitranscriptomic modification involved in messenger RNA (mRNA) stability and translation efficiency various biological processes. However, it remains unclear if m5C contributes to the dynamic regulation of transcriptome during developmental cycles Plasmodium parasites. Here, we characterize landscape mRNA modifications at single nucleotide resolution asexual replication stages gametocyte sexual rodent (Plasmodium yoelii) human falciparum) malaria While...
A series of [2]catenanes were efficiently synthesized in high yields by a template-directed clipping approach with the formation one macrocycle around another containing dialkylammonium recognition site. Their structures identified NMR spectra and ESI mass spectrometry, their geometries investigated theoretical calculation.
Growing evidence suggests that the pyrrolizidine alkaloids (PAs)-induced hepatotoxicity is mediated by multiple cell death/defence modalities. However, detailed mechanisms are still lacking. In this study, hepatotoxic effects of four PAs including three retronecine-type ones (senecionine, seneciphylline and monocrotaline) one otonecine-type (clivorine) on proliferation Huh-7.5 cells possible were investigated. The results showed all could inhibit induce apoptosis in a concentration-dependent...
Abstract Background Confocal laser endomicroscopy (CLE) requires fluorescence agents, the use of which leads to blurred images and low diagnostic accuracy owing fluorescein leakage. We aimed explore whether multiphoton imaging (MPI) could serve as a better method optical biopsy. Methods First, pilot study was performed set up criteria MPI for benign or malignant colorectal lesions in 30 patients. Then, blinded conducted compare sensitivity, specificity, versus CLE 79 Results In study,...
The development and maturation of follicles is a sophisticated multistage process. dynamic gene expression oocytes their surrounding somatic cells the dialogs between these are critical to this In study, we accurately classified oocyte follicle into nine stages profiled mouse granulosa cumulus cells. clustering transcriptomes showed trajectories two distinct courses Gene changes precipitously increased at Type 4 stage drastically dropped afterward within both Moreover, number differentially...
Abstract Serial analysis of gene expression (SAGE) was used to examine the profile expressed genes during embryonic development in domesticated silkworm, Bombyx mori, after irradiation with Cobalt‐60. A comparison SAGE sequence tags derived from irradiated embryos those normal revealed 673 differentially ( P < 0.01 and at least three folds change). Of these, 292 were highly 381 embryos. These results provide valuable information for understanding mechanisms radiation‐induced changes...
Gastric cancer is a significant global health concern with complex molecular underpinnings influencing disease progression and patient outcomes. Various drivers were reported, these studies offered potential avenues for targeted therapies, biomarker discovery, the development of precision medicine strategies. However, it was posed that heterogeneity complexity interactions are still challenging. By seamlessly integrating data from single-cell RNA sequencing (scRNA-seq) bulk (bulk RNA-seq),...
In the title molecule, C16H18Se2, dihedral angle between benzene rings is 93.1 (3)°. crystal structure, there are no significant hydrogen bonding interactions or π–π stacking interactions.
In the title mol-ecule, C(14)H(10)O(4)Se, dihedral angle between two benzene rings is 74.6 (1)°. Both hy-droxy-benzaldehyde groups form intra-molecular O-H⋯O hydrogen bonds. crystal, pairs of mol-ecules are linked by weak C-H⋯π(arene) inter-actions, forming centrosymmetric dimers. addition, π-π stacking with a centroid-centroid distance 3.785 (2) Å, chains along c axis.
IN THE TITLE COMPOUND [SYSTEMATIC NAME: 13,15-dibromo-3,10-dithia-tricyclo-[10.2.2.2(5,8)]octa-deca-1(14),5,7,12,15,17-hexa-ene-6-carbonitrile], C(17)H(13)Br(2)NS(2), the mean planes of benzene rings are almost parallel, making a dihedral angle 1.1 (2)°, and distance between ring centroids is 3.294 (3) Å, which shorter than normal packing aromatic (about 3.4 Å), indicating strong π-π inter-action. The S atom one bridging chain disorderd over two positions with site occupancies 0.605 (4)...
Abstract 5-methylcytosine (m 5 C) is an important epitranscriptomic modification involved in mRNA stability and translation efficiency various biological processes. However, it remains unclear if m C contributes to the dynamic regulation of transcriptome during developmental cycles Plasmodium parasites. Here, we characterize landscape modifications at single nucleotide resolution asexual replication stages gametocyte sexual rodent ( P. yoelii ) human falciparum malaria While different...