A5103237596- Thyroid Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Thyroid and Parathyroid Surgery
- Lung Cancer Research Studies
- RNA modifications and cancer
- Clusterin in disease pathology
- Oral and Maxillofacial Pathology
- Hepatitis B Virus Studies
- Musculoskeletal synovial abnormalities and treatments
- Sarcoma Diagnosis and Treatment
- Head and Neck Anomalies
- Inflammasome and immune disorders
- BRCA gene mutations in cancer
- Galectins and Cancer Biology
- Urinary and Genital Oncology Studies
- CNS Lymphoma Diagnosis and Treatment
Shanghai Medical College of Fudan University
2017-2024
Fudan University Shanghai Cancer Center
2017-2024
Nanjing Medical University
2023-2024
Jiangsu Province Hospital
2023-2024
Nanjing Drum Tower Hospital
2021-2023
Inner Mongolia Agricultural University
2022
Shanxi Medical University
2019-2020
University of Electronic Science and Technology of China
2013
Jinshan Hospital of Fudan University
2013
Guilin University of Technology
2012
Abstract The tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using single-cell RNA sequencing, we profile transcriptomes 158,577 cells from 11 patients’ paratumors, localized/advanced tumors, initially-treated/recurrent lymph nodes and radioactive iodine (RAI)-refractory distant metastases, covering comprehensive clinical courses PTC. Our data identifies a “cancer-primed” premalignant thyrocyte population with normal morphology but altered transcriptomes. Along...
Recent studies have shown that traditional Chinese medicine (TCM), such as gambogic acid (GA), is involved in the regulation of tumor immune microenvironment and can be combined with other anti-tumor treatment strategies. Here, we used GA an adjuvant to construct a nano-vaccine improve response colorectal cancer (CRC).We previously reported two-step emulsification method obtain poly (lactic-co-glycolic acid) /GA nanoparticles (PLGA/GA NPs), then CT26 colon cell membrane (CCM) was CCM-PLGA/GA...
TERT reactivation occurs frequently in human malignancies, especially advanced cancers. However, vivo functions of cancer progression and the underlying mechanism are not fully understood. In this study, we expressed and/or active BRAF (
Medullary thyroid cancer (MTC) often exhibits aggressive growth with distant organ metastasis, leading to poor survival.
Objectives: To develop reliable nomograms to estimate individualized overall survival (OS) and cancer specific (CSS) for patients with primary small cell carcinoma of the bladder (SCCB) compare predictive value AJCC stages. Patients Methods: 582 eligible SCCB identified in Surveillance, Epidemiology, End Results (SEER) dataset were randomly divided into training (n=482) validation (n=100) cohorts. Akaike information criterion was used select clinically important variables multivariate Cox...
Abstract Context Programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte activation gene-3 (LAG-3), ITIM domain (TIGIT) are considered major immune co-inhibitory receptors (CIRs) the most promising immunotherapeutic targets in cancer treatment, but they largely unexplored medullary thyroid carcinoma (MTC). Objective We aimed to provide first evidence regarding expression profiles clinical...
The abnormality of interleukin-21 (IL-21)-IL-21-receptor (IL-21R) system has been found in many autoimmune diseases including thyroid (AITDs). In this study, we investigated whether polymorphisms the IL-21 and IL-21R are associated with Graves' disease (GD) Hashimoto's thyroiditis (HT), two major forms AITDs, among a Chinese population.Rs907715, rs4833837, rs2221903 rs2055979 gene rs3093301 rs2285452 were explored case-control study 405 GD, 228 HT patients 242 controls. These genes genotyped...
Epstein-Barr virus (EBV) infection is associated with a better response to anti-PD1 immunotherapy. We hypothesised that genetic alterations induced by EBV are responsible for the activation of key immune responses and hence predictive efficacy.With transcriptome data gastric cancer (GC), we explored differentially expressed genes (DEGs) specific performed coexpression network analysis using DEGs identify consistent (CCGs) between EBV-positive EBV-negative GC tissues. selected tag CCGs...
Neck dissection for laryngeal squamous cell carcinoma (LSCC) patients could provide complementary prognostic information AJCC N staging, like lymph node ratio (LNR). The aim of this study was to develop effective nomograms better predict survival LSCC treated with neck dissection.2752 were identified and randomly divided into training (n = 2477) validation 275) cohorts. 3- 5-year probabilities cancer-specific mortality (CSM) 30.1% 37.2% while death resulting from other causes (DROC) rate...
Abstract Use of immune index is a new potential approach for cancer classification and prediction. To investigate the status clinical effect in gallbladder (GBC), 238 GBC patients from Zhongshan Hospital affiliated to Fudan University were involved present study, including 113 training set 125 validation set. Five cells (macrophages, neutrophils, regulatory T cells, cytotoxic mast cells) selected based on literature review each patient was calculated using LASSO regression. A low (<1)...
Patients with anaplastic thyroid cancer (ATC), which is among the deadliest of all cancers, often have a poor response to traditional therapies. Currently, role long non-coding RNAs (lncRNAs) in ATC carcinogenesis unclear. In this study, we analyzed lncRNA expression profile aim identifying potential molecular targets for treatment disease.Whole transcriptome sequencing three and two normal (NT) samples was performed, analyzed. Original data as well datasets deposited Gene Expression Omnibus...
Background:The aim of this study was to develop and validate prognostic nomograms predicting overall (OS) cancer-specific survival (CSS) patients with major salivary gland (MaSG) mucoepidermoid carcinoma (MEC).Methods: 1398 MaSG-MEC were identified from the Surveillance, Epidemiology End Results (SEER) database.They randomly equally divided into a training cohort (n=699) validation (n=699).The best subsets covariates OS CSS based on smallest Akaike Information Criterion (AIC) value in...
Abstract Purpose The role of lymph node ratio (LNR, metastatic to examined nodes) in the staging multiple human malignancies has been reported. We aim evaluate its value salivary gland cancer (SGC). Methods Records SGC patients from Surveillance, Epidemiology, and End Results database (SEER, training set, N = 4262) Fudan University Shanghai Cancer Center (FUSCC, validating 154) were analyzed for prognostic LNR. Kaplan–Meier survival estimates, Log-rank χ 2 test Cox proportional hazards model...
Wei-Dong Ye, Li-Cheng Tan, Yulia Andreevna Veryaskina, Pei-Zhen Han, Peng-Cheng Yu, Xiao Shi, Wan-Lin Liu, Zhen-Tian Kai, Rui-Jue Lin, Li-Sha Huang, Arseny Semenov, Igor Fyodorovich Zhimulev, Qing-Hai Ji, Ning Qu, Sergei Evgenievich Titov, Yu-Long Wang
Plasmodiophora fire of broad bean is responsible for Olpidium Viciae Kusano, which a kind Fungi subdivided into bacteria flagellum amon. We have developed polymerase chain reaction based method the rapid identification internal transcribed spacer (ITS) regions productionally significant fungi Kusano from areas 2500~3000 metres above sea level. Sequences nuclear ITS1 and ITS4 been used widely in molecular characteristic studies because their relatively high variability facility amplification....
To clarify the influence of changes in overlying water environment on internal nitrogen release from reservoir sediments different seasons, quantitative linear relationship between intensity sediment and environmental factors was established, their contribution rate to pollution during storage periods investigated. In this study, samples were collected Dahekou Reservoir Xilingol League, orthogonal simulation experiments conducted laboratory. The mathematical model, which established using...
Lymph node metastasis can independently predict oral squamous cell carcinoma patients' survival. This study would investigate the genetic and cellular differences between with positive negative lymph metastases.We gathered single-cell RNA sequencing bulk gene expression data from Cancer Genome Atlas Gene Expression Omnibus databases. Sixty node-metastasis-related genes were discovered refined analysis, consensus clustering provided three molecular subtypes of carcinoma. Least absolute...
Primary mediastinal large B-cel l lymphoma (PMBCL) is a rare subtype of B-cell that not yet fully understood. This population-based study aimed to assess the latest survival and treatment strategies for patients with PMBCL.The used dataset from Surveillance, Epidemiology, End Results Program registry retrospectively analyze adult diagnosed PMBCL between 2001 2018. The primary outcome measures included overall (OS) disease-specific (DSS).Among 814 identified cases, revealed 5-year OS rate...