A5052753139- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Phytochemical Studies and Bioactivities
- Cancer, Lipids, and Metabolism
- Advanced X-ray and CT Imaging
- Proteoglycans and glycosaminoglycans research
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Medical Imaging and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Colorectal Cancer Surgical Treatments
- Liver physiology and pathology
- Colorectal Cancer Treatments and Studies
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Infrared Thermography in Medicine
- Liver Disease and Transplantation
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Bioenergy crop production and management
Shanghai University of Traditional Chinese Medicine
2004-2025
Nielsen (United States)
2021
Shanghai Traditional Chinese Medicine Hospital
2006-2021
Huashan Hospital
2018
Fudan University
2018
Shanghai Jiao Tong University
2012-2017
Ruijin Hospital
2017
Shanghai University
2012-2013
Shuguang Hospital
2002-2004
Objectives: To develop reliable nomograms to estimate individualized overall survival (OS) and cancer specific (CSS) for patients with primary small cell carcinoma of the bladder (SCCB) compare predictive value AJCC stages. Patients Methods: 582 eligible SCCB identified in Surveillance, Epidemiology, End Results (SEER) dataset were randomly divided into training (n=482) validation (n=100) cohorts. Akaike information criterion was used select clinically important variables multivariate Cox...
The Copper Metabolism MURR1 Domain (COMMD) family proteins are known to play roles in promoting or inhibiting the proliferation, migration and invasion of tumor cells. However, role COMMD3 hepatocellular carcinoma still unclear. By investigating TCGA datasets, we found that mRNA expression was significantly upregulated tissue compared with normal liver tissue, which further supported by Oncomine dataset, Western blot, qRT-PCR, IHC analysis. Moreover, Kaplan-Meier survival analysis showed...
Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies in world whose chemoprevention became increasingly important HCC treatment. Although anticancer effects asparagus constituents have been investigated several cancers, its on hepatocellular not fully studied. In this study, we deproteinized polysaccharide cells using vitro and vivo experimental model. Our data showed that might act as an effective inhibitor cell growth exert potent selective cytotoxicity against human...
Aim: Although there are so many treatment strategies used for hepatocellular carcinoma (HCC), the overall survival (OS) of HCC patients still remains very low.In our previous studies, asparagus polysaccharide (ASP) has been demonstrated to suppress proliferation, migration, invasion and angiogenesis cells under normoxic conditions in vitro.However, inhibitory effects ASP on hypoxia-induced remain largely unexplored.Materials methods: Cell Counting Kit-8 (CCK-8) assay, transwell tube...
Hypoxia could enhance radioresistance in prostate cancer cells through up-regulating HIF-1α, which be inhibited by statins several cells. However, this effect of remains unclear. In the present study, we aim to investigate atorvastatin on HIF-1α expression and radiosensitivity The hypoxia-induced human PC3 were generated incubating with 5% O2 for 24 h. cell viability apoptosis respectively analyzed counting kit-8 (CCK-8) assay flow cytometry. protein was assessed Western blotting....
Hypoxia-inducible factor-1α (HIF-1α) plays a key role by triggering the transcriptional activation of number genes involved in migration, invasion, and angiogenesis hepatocellular carcinoma (HCC). Thus, suppressing tumour growth targeting HIF-1α/VEGF signalling pathway represents promising strategy for treatment HCC. In our previous studies, we found that asparagus polysaccharide (ASP) suppressed proliferation promoted apoptosis HCC cells both vivo vitro. To further explore potential...
Hepatocellular carcinoma (HCC) has become a leading cause of cancer-associated mortality worldwide and is thus great concern. Although various chemotherapeutic drugs are currently used for the treatment HCC, severe side effects associated with these treatments have prompted interest in novel therapies, including use certain biological macromolecules such as polysaccharides. Several studies shown that polysaccharides anticancer antiproliferative on HCC. Vascular endothelial growth factor,...
Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There an urgent need for the development novel therapies this deadly disease. It has been proven that asparagus polysaccharide, most active derivates from traditional medicine asparagus, possesses notable antitumor properties. However, little known about efficacy polysaccharide as adjuvant liver chemotherapy. Herein, we reported its embolic agent form, gum, significantly inhibited tumor growth...
High expression of copper metabolizing MURR1 domain (COMMD3) is significantly correlated with poor prognosis in hepatocellular carcinoma (HCC) patients. Here, we explored the mechanism by which COMMD3 affects HCC angiogenesis through HIF1α/VEGF/NF-κB signaling pathway. SK-Hep1 and Hep-3B cell lines were transfected overexpression RNA interference lentivirus verified using RT-qPCR western blotting techniques. Using sequencing, analyzed differentially expressed genes COMMD3-overexpressed...
HIF1α mRNA expression in hepatocellular carcinoma (HCC) tissues and its relationship with the prognosis HCC patients is still unclear. We performed this study to investigate of correlation patients.GSE14520 Oncomine database were used analyse differential among corresponding peritumour or normal liver tissues. The between clinicopathological features survival was analysed using GSE14520 dataset. CCK-8 assay, wound-healing transwell invasion tube formation subcutaneous xenograft tumour assays...
Hepatocellular carcinoma (HCC) is the main form of primary liver cancer and one most prevalent life-threatening malignancies globally. Hypoxia activates hypoxia-inducible factor-1α (HIF-1α), which key factor in promoting angiogenesis HCC. Currently, there are few studies on effects HIF-1α-targeted gene therapy combined with traditional Chinese herbal extracts.We investigated HIF-1α RNA interference (RNAi) asparagus polysaccharide (ASP) HCC vitro vivo.CCK-8, wound-healing, transwell, human...
Marketing mix models (MMMs) are statistical for measuring the effectiveness of various marketing activities such as promotion, media advertisement, etc. In this research, we propose a comprehensive model that captures hierarchical structure and carryover, shape scale effects certain activities, well sign restrictions on coefficients consistent with common business sense. contrast to commonly adopted approaches in practice, which estimate parameters multi-stage process, proposed approach...