A5025223478- Head and Neck Cancer Studies
- Liver Disease Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Reconstructive Surgery and Microvascular Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Head and Neck Surgical Oncology
- Diet, Metabolism, and Disease
- Tracheal and airway disorders
- Colorectal and Anal Carcinomas
- Thyroid Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Folate and B Vitamins Research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Diagnosis and Treatment
- Lipid metabolism and disorders
- Effects and risks of endocrine disrupting chemicals
- Biomarkers in Disease Mechanisms
- Diabetes Treatment and Management
- Reconstructive Facial Surgery Techniques
- Lung Cancer Treatments and Mutations
Sun Yat-sen University
2013-2025
Sun Yat-sen University Cancer Center
2010-2025
State Key Laboratory of Oncology in South China
2018-2024
Xuzhou Medical College
2014-2024
Xuzhou Central Hospital
2014-2024
Southeast University
2014-2024
Nanjing Medical University
2019-2024
Key Laboratory of Guangdong Province
2023-2024
Jiangsu University
2023
Xuzhou Cancer Hospital
2023
Abstract Neoadjuvant chemoimmunotherapy has emerged as a potential treatment option for resectable head and neck squamous cell carcinoma (HNSCC). In this single-arm phase II trial (NCT04826679), patients with locally advanced HNSCC (T2‒T4, N0‒N3b, M0) received neoadjuvant camrelizumab (200 mg), nab-paclitaxel (260 mg/m 2 ), cisplatin (60 ) intravenously on day one of each three-week cycle three cycles. The primary endpoint was the objective response rate (ORR). Secondary endpoints included...
Nanomedicines for combining chemotherapy and sonodynamic therapy (SDT) have enormous potential in squamous cell carcinoma treatment. However, the therapeutic efficacy of noninvasive SDT is severely limited because generation reactive oxygen species (ROS) by sonosensitizers highly dependent on levels intracellular excess glutathione (GSH) tumor cells. To overcome this barrier, a red blood (RBC) membrane-camouflaged nanomedicine consisting GSH-sensitive polyphosphoester (SS-PPE) ROS-sensitive...
Background The availability of research on short-term ozone therapy for diabetic foot ulcers (DFUs) is limited, and even when it accessible, mainly comprises basic analysis conducted during long-term therapy. This study was to evaluate the efficacy in promoting wound healing DFUs. Methods A retrospective 89 patients with type 2 diabetes complicated by were divided into two groups: group (n=41) control (n=48). Wound condition, change bacterial types, changes inflammatory indicators...
Global data demonstrate minimal improvement in the survival rate for oral cavity cancer (OCC) patients. We wished to know whether or not clinical features and have changed over time OCC patients receiving initial treatment follow-up at a large center China.Clinical were collected on diagnosed during successive decades of 1960-1969 (n=253), 1970-1979 (n=497), 1980-1989 (n= 659), 1990-1999 (n=793), 2000-2009 (n=1,160) Sun Yat-sen University Cancer Center.Over time, overall 5-year was 52.0%....
While immunotherapy has emerged as a promising strategy to treat melanoma, the limited availability of immunotherapeutic agents in tumors due immunosuppressive tumor microenvironment dampens its efficacy. Pyroptosis is gasdermin-mediated programmed necrosis that triggers inflammatory and enhances efficacy immunotherapy. Here, we prove CXCR4 antagonist T22 peptide specially targeted became internalized into CXCR4+ melanoma cells. Then report self-assembling nanotoxin can be used...
Abstract The present study utilized the National Health and Nutrition Examination Survey (NHANES) database to examine relationship between serum levels of heavy metals Diabetic retinopathy (DR) in individuals aged over 30 years with type 2 diabetes mellitus (T2DM) United States. A cross-sectional analysis was conducted on 1583 T2DM from NHANES 2011–2020, including 331 DR group 1252 non-DR group. We collected data metals, DR, albumin for descriptive statistics, linear regression, logistical...
Expression of the Neuropilin-1 (NRP1) is reported in malignant cells multiple human tumor types represented as a marker. Targeting NRP1 with peptide, CK3, used for molecular imaging, raising question therapeutic potential CK2, peptide CK3 backbone which enhanced targeting and enrichment properties. The capacity CK2 was detected by IncuCyte, flow cytometry animal living imaging. To enhance its efficacy, we developed self-assembling nanoparticles Fmoc-Gffy-AP-CK2, incorporating protective...
The SmI2-mediated radical coupling reactions of β-hydroxylated pyrrolidine/piperidine aza-hemiacetals 8 and 9 N,S-acetals 6 33 with α,β-unsaturated compounds are described. This method allows a rapid access to pyrrolidines, piperidines, pyrrolizidinones, indolizidinones. Starting from N,S-acetal via common intermediate 27, the alkaloids hyacinthacine A2 (2), uniflorine A (3, 6-epi-casuarine), unnatural epimer 7-epi-casuarine (37) have been synthesized in four five steps overall yields 34%,...
Abstract Metastasis is the main cause of laryngeal cancer-related death; its molecular mechanism remains unknown. Here we identify protein arginine methyltransferase 5 (PRMT5) as a new metastasis-promoting factor in carcinoma, and explore underlying action regulating cancer progression. We illustrated that PRMT5 expression was positively correlated with tumor stages, lymphatic metastasis, unfavorable outcome. Functional assays revealed promoted carcinoma cell proliferation, migration,...
Abstract GTPase-activating protein-binding protein 2 (G3BP2) is a key stress granule-associated RNA-binding responsible for the formation of granules (SGs). Hyperactivation G3BP2 associated with various pathological conditions, especially cancers. Emerging evidence indicates that post-translational modifications (PTMs) play critical roles in gene transcription, integrate metabolism and immune surveillance. However, how PTMs directly regulate activity lacking. Here, our analyses identify...
Identification and intervention of left ventricular hypertrophy (LVH) in essential hypertension (EH) are important for the prevention adverse cardiovascular events. However, effective methods diagnosing LVH still lacking. This study aimed to explore relationship between soluble ST2 (sST2) EH patients identify a potential specific biomarker hypertensive LVH.This included 97 patients. Based on criteria LVH, participants were divided into group (n = 52) non-LVH 45). The level serum sST2 was...
The one-pot reductive coupling of N-acylcarbamates with activated alkenes is described. method based on partial reduction DIBAL-H, followed by N-acyliminium ion formation and SmI2-mediated radical alkenes. Both acyclic cyclic can be used as stable substrates, a range serve effective receptors. L-N-acylcarbamates 12/13 gave 2,5-disubstituted pyrrolidine derivatives in high trans-diastereoselectivities. penta-2,4-dienoate proceeded exclusively 1,6-addition fashion, producing single...
Our aim in this study was to investigate the value of submandibular salivary gland transfer procedure prevention radiation-induced xerostomia patients with nasopharyngeal carcinoma (NPC).In all, there were 70 patients, consisting a test group (36 patients) and control (34 nonrandomized fashion. In group, transferred submental space before radiotherapy (XRT) shielded. Salivary functions evaluated by amount saliva quality life questionnaire after XRT 3 60 months XRT.At 5 years, trapping...
Neck circumference (NC) has been previously related to cardiometabolic risk factors. In this study we examined the association between NC and early stage atherosclerosis in Chinese adults. The samples were from a community-based health examination survey central China. total 2,318 men women (18-64 y) included final analyses. Carotid radial pulse wave velocity (crPWV), carotid femoral PWV (cfPWV), artery dorsalis pedis (cdPWV) measured. After adjustment for age, sex, lipids, glucose, blood...
Objective To compare survival effects of comprehensive neck dissection (CND) and selective (SND) for patients with nasopharyngeal carcinoma (NPC) only regional failure. Methods A total 294 recurrent T0N1‐3M0 NPC who underwent in Sun Yat‐Sen University Cancer Center, Guangzhou, People's Republic China, between January 1984 February 2014, were enrolled the interaction analyses. Using propensity scores to adjust potential prognostic factors, an additional well‐balanced cohort 210 was...
The tumor-targeting iLIP<sub>ICG</sub> provides a promising strategy to improve the precision imaging and effective phototherapy for treatment of laryngeal carcinoma.
Many previous studies have reported the association between iron overload (IO) and type 2 diabetes mellitus (T2DM). However, underlying molecular mechanism is not clear.Epidemiological data from National Health Nutrition Examination Survey 2017-2018 (NHANES) was used to systematically explore IO diabetes. Furthermore, transcriptome Gene Expression Omnibus (GEO) were analyzed using bioinformatics methods functional mechanisms at level.Data NHANES showed a "W" shape relationship serum (frozen)...
Evidence is accumulating of the therapeutic benefits mesenchymal stromal cells (MSCs) in diabetes-related conditions. We have identified a novel population within islets Langerhans - islet stellate (ISCs) which similar morphology to MSCs. In this study we characterize mouse ISCs and compare their function MSCs determine whether may also potential diabetes.