A5043099569- Prostate Cancer Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Cardiac Fibrosis and Remodeling
- Advanced MIMO Systems Optimization
- Receptor Mechanisms and Signaling
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Ion channel regulation and function
- Nerve injury and regeneration
- Diabetes Treatment and Management
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Cancer, Lipids, and Metabolism
- Folate and B Vitamins Research
- Genetics and Neurodevelopmental Disorders
- Urinary and Genital Oncology Studies
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Endometriosis Research and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- RNA modifications and cancer
- Full-Duplex Wireless Communications
- Congenital heart defects research
University of Electronic Science and Technology of China
2023-2025
Second Military Medical University
2020-2025
Shanghai Changzheng Hospital
2013-2025
Jiangsu University
2024
Second Affiliated Hospital of Jilin University
2024
Xuzhou Central Hospital
2009-2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022-2023
Guangzhou Development Zone Hospital
2023
Guangdong Academy of Sciences
2023
Guangxi Medical University
2023
Lamin B receptor (LBR), a chromatin and lamin binding protein in the inner nuclear membrane, has been proposed to play vital role envelope (NE) assembly. But specific for LBR NE assembly remains unknown. In present study, we show that overexpression of causes membrane overproduction, inducing invagination stack formation, these processes require transmembrane domain LBR. Biochemical analysis shows N-terminal directly interacts with importin β Ran sensitive α independent manner. Using an...
Network-assisted full-duplex (NAFD) distributed massive multiple-input multiple-output (MIMO) systems enable simultaneous uplink and downlink communications by dynamically allocating the numbers of remote antenna units (RAUs), which potentially improve spectral efficiency in wireless communications. In such systems, channel state information (CSI) plays a critical role reception transmission, as well cross link interference cancelation caused RAUs to RAUs. Moreover, terminals need estimate...
Introduction Zinc (Zn) is an essential trace element in animals, but excessive intake can lead to renal toxicity damage. Thus, the exploration of effective natural antagonists reduce caused by Zn has become a major scientific problem. Methods Here, we found that hesperidin could effectively alleviate induced pigs using hematoxylin-eosin staining, transmission electron microscope, immunohistochemistry, fluorescence quantitative PCR, and microfloral DNA sequencing. Results The results showed...
Abstract Background: Diabetic foot is a complex condition with high incidence, recurrence, mortality, and disability rates. Current treatments for diabetic ulcers are often insufficient. This study was conducted to identify potential therapeutic targets foot. Methods: Datasets related skin were retrieved from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) identified using R software. Enrichment analysis screen critical gene functions pathways. A protein...
Background: Damage to Schwann cells has been reported in the development of diabetic peripheral neuropathy (DPN), but how are damaged not elucidated. Methods: The highly expressed proteins PBMC DPN patients were identified through MALDI-TOF/TOF and SELDI protein chip technology. expression levels CXCR3 detected by qPCR flow cytometric analysis. Transwell migration assay was investigate CD8+ T cells. Western-blot analysis detect p38 MAP kinases pathway related TNF-α, FasL, PDL1. Results: Two...
Background/Aims: High glucose-induced oxidative stress and inflammatory responses play an important role in painful diabetic neuropathy by activating the TLR4/NFκB signal pathway. Schwann cells (SCs) are integral to peripheral nerve biology, contributing saltatory conduction along axons, axon development, axonal regeneration. SCs provide a microenvironment favoring vascular regeneration but their low survival ratio hyperglycemic conditions suppress function promote growth. Nuclear factor...
Renal cell carcinoma (RCC) originates from the epithelial cells of renal tubules and has a high degree malignancy heterogeneity. Recent studies have found that exosomes regulate intercellular communication via transferring various bioactive molecules, such as circular RNAs (circRNAs), which are critical for cancer progression. However, role tumor cell-derived exosomal circRNAs in RCC remains unclear. In this study, we reported expression circ-PRKCI tissues serum exosomes. We also could be...
Many previous studies have reported the association between iron overload (IO) and type 2 diabetes mellitus (T2DM). However, underlying molecular mechanism is not clear.Epidemiological data from National Health Nutrition Examination Survey 2017-2018 (NHANES) was used to systematically explore IO diabetes. Furthermore, transcriptome Gene Expression Omnibus (GEO) were analyzed using bioinformatics methods functional mechanisms at level.Data NHANES showed a "W" shape relationship serum (frozen)...
Mitochondrial DNA (mtDNA) plays a key role in diabetes mellitus and metabolic syndrome (MetS). An increasing number of studies have reported the association between mtDNA copy (mtDNA-CN) risk MetS; however, associations remain conflicted systematic review meta-analysis on mtDNA-CN MetS is lacking.We aimed to investigate using observational studies.PubMed, EMBASE, Web Science were searched up December 15, 2022. Random-effect models used summarize relative risks (RRs) 95% CIs.A total 19...
Abstract Previous studies have reported that the significant association between serum calcium and mortality substantially in patients, especially among those with intensive care unit (ICU). And In diabetes mellitus, congestive heart failure (CHF) is a comorbidity. We aim to evaluate levels in-hospital patients failure. The participants this study were extracted from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. To scrutinize potential associations mortality,...
Abstract To compare the clinical efficacy of an innovative modified single-incision technique without special extraperitoneal PORT with that transperitoneal multi-incision robot-assisted laparoscopic radical prostatectomy and to explore feasibility safety former. A retrospective analysis was performed on 259 patients who received in Robot Minimally Invasive Center Sichuan Provincial People's Hospital between September 2018 August 2021. Among them were 147 cases involving single incision no...
To cope with the exploding demand for higher data rate and heavier asymmetry of downlink (DL) uplink (UL) traffic, dynamic time-division duplex (DTDD) has been proposed, where time resources can be adjusted dynamically between DL UL transmission. However, strict synchronization requirements in DTDD bring extra overhead. In this paper, a bidirectional network (BDN) massive multiple input output is studied, which transmission occur simultaneously. Under imperfect channel-state information,...
Emerging evidence suggests that T2DM is attributable to the dysfunction of β-cells and activation islet stellate cells (ISCs). The wingless-type MMTV integration site family member 5a (Wnt5a)/frizzled 5 (Fzd5) signalling pathway might take part in this process. Our study aimed at defining status ISCs during β-cell insulin secretion homeostasis by determining role Wnt5a protein regulation production. We examined effects on normoglycemic db/m hyperglycaemic db/db mice. iTRAQ screening RNA...
Hypertrophic scars (HSs) are a type of pathological scar which induced by surgery, burn injuries or trauma during the healing process. Due to high recurrence rates and strong invasive properties, HSs have become major clinical issue. Resveratrol has been identified as potential agent suppress formation; however, underlying mechanism action remains unclear. Therefore, present study aimed investigate effect resveratrol on HS-derived fibroblasts (HSFBs) in vitro. MTT assay was performed...
Bone marrow mesenchymal stem cells (BMSCs) have the potential to transdifferentiate into cardiomyocyte‑like (CLCs) if an appropriate cardiac environment is provided. Insulin‑like growth factor‑1 (IGF‑1) plays important role in cell migration, survival and differentiation of BMSCs. However, effect IGF‑1 on cellular remains unclear. In present study, BMSCs were isolated from rat femurs tibias purified at passage 6 (P6). receptor (IGF‑1R) kinase inhibitor I‑OMe AG538 added detect could induce...
Objective To investigate the learning curve under different surgical complexity in endoscopic transsphenoidal approach for pituitary adenoma. Methods 273 patients undergoing surgery adenoma were collected retrospectively and divided into three groups chronologically (early, middle, late periods). Surgical was differentiated based on Knosp classification (Knsop grade 0–2 vs. 3–4), tumor maximum diameter (MD) (macroadenomas giant adenomas), history of previous (first operation reoperation)....
Inflammation plays a crucial role in the development of diabetic cardiomyopathy (DCM), including inflammation caused by high-glucose and high-lipid (HGHL). Targeting may provide useful strategy for preventing treating DCM. Puerarin has been shown to reduce inflammation, apoptosis hypertrophy cardiomyocytes induced HGHL, which this study aims investigate underlying mechanisms.H9c2 cultured with HGHL were used establish cell model was then placed these cells 24 hours. The effects puerarin on...