A5048249240- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Luminescence and Fluorescent Materials
- Crystallography and molecular interactions
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Glass properties and applications
- Synthetic Organic Chemistry Methods
- Solid State Laser Technologies
- Radiopharmaceutical Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Luminescence Properties of Advanced Materials
- Sulfur Compounds in Biology
- Nanoparticle-Based Drug Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Click Chemistry and Applications
- Advanced Photocatalysis Techniques
- Advanced Surface Polishing Techniques
- Advanced ceramic materials synthesis
- Synthesis and Characterization of Pyrroles
- Protease and Inhibitor Mechanisms
- Energetic Materials and Combustion
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
National University of Singapore
2022-2024
Weifang People's Hospital
2024
Weifang Medical University
2024
Jiangxi University of Traditional Chinese Medicine
2024
Lanzhou University
2009-2024
Jining First People's Hospital
2017-2023
Jining Medical University
2017-2023
Wuhan Polytechnic University
2023
Chemical construction of molecularly organic–inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs) with silsesquioxane framework is expected to substantially improve their therapeutic performance and enhance the biological effects beneficial for biomedicine. In this work, we report on a simple, controllable, versatile chemical homology principle synthesize multiple-hybridized HMONs varied functional organic groups homogeneously incorporated into (up quintuple hybridizations)....
Passing the baton: A relay cascade process provides cyclohexanes in a direct, efficient, and stereoselective manner. The triple-cascade reaction is affords high selectivities, has broad scope, different diastereomers are readily accessible by judicious choice of organocatalysts. Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: publisher...
A prerequisite for the development of photocatalysis techniques is to obtain photocatalysts with remarkable activity. Herein, we have reported BiOBr/WO3 p–n heterojunctions as novel and efficient visible-light-driven photocatalysts. The been prepared through an electrospinning–calcination–solvothermal method, they all present a flower-like superstructure. photocatalytic activities these are investigated by degrading rhodamine B (RhB), methyl orange (MO) para-chlorophenol (4-CP) under visible...
Rationale: Fibroblast activation protein (FAP) targeted molecular imaging radiotracers have shown promising preclinical and clinical results in tumor diagnosis. However, rapid clearance inadequate retention of these molecules hindered them for further translation cancer therapy. In this study, we aimed to develop a series albumin binder-truncated Evans blue (EB) modified FAP radiotracers, optimize the pharmacokinetic (PK) characteristics overcome existing limitations order apply radionuclide...
Endoscopy is a clinical gold standard to exam the interior of hollow organ or body cavity. For first time, this study presents design and construction fluorescent endoscopic system that harnesses power second near-infrared window II (NIR-II) fluorescence imaging. An NIR-II molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) targets vascular endothelial growth factor (VEGF), successfully synthesized evaluated along with endoscopy imaging system. Simultaneous white-light...
To enhance tumor uptake and retention, we designed developed bi-specific heterodimeric radiotracers targeting both FAP αvβ3, [ 68 Ga]Ga-FAPI-RGD.The present study aimed to evaluate the specificity, pharmacokinetics, dosimetry of Ga]Ga-FAPI-RGD by preclinical preliminary clinical studies.Methods: FAPI-RGD was synthesized with quinoline-based FAPI-02 cyclic RGDfK peptide.Preclinical pharmacokinetics were determined in Panc02 xenograft model using microPET biodistribution experiments.The safety...
Abstract Purpose: Fibroblast activation protein (FAP) is a promising target for tumor treatment. In this study, we aimed to investigate the safety and efficacy of albumin binder-conjugated FAP-targeted radiopharmaceutical, 177Lu-EB-FAPI (177Lu-LNC1004), in patients with metastatic radioiodine-refractory thyroid cancer (mRAIR-TC). Patients Methods: This open-label, non-randomized, first-in-human, dose-escalation, investigator-initiated trial had 3+3 design involved 6-week 177Lu-LNC1004...
Radiolabeled fibroblast activation protein (FAP) inhibitors (FAPIs) and Arg-Gly-Asp (RGD) peptides have been extensively investigated for imaging of FAP- integrin α<sub>v</sub>β<sub>3</sub>–positive tumors. In this study, a FAPI-RGD heterodimer was radiolabeled with <sup>68</sup>Ga evaluated in patients cancer. We hypothesized that the heterodimer, recognizing both FAP α<sub>v</sub>β<sub>3</sub>, would be advantageous because its dual-receptor–targeting property. <b>Methods:</b> The...
Halogenated tetraphenylethene derivatives show an anomalous anti-heavy-atom effect where introducing heavy halogens into the typical AIEgen greatly improves fluorescence quantum yield upon aggregation, and a self-reversible mechanochromism.
We report a general design strategy for new class of luminogens with dual-state emission (DSEgens) that are brightly emissive in both the solution and solid state, solvatochromism properties, by constructing partially shared donor-acceptor pattern based on twisted molecule. The DSEgens bright fluorescence state demonstrate unique behaviour depending solvent polarity thus may have applications anti-counterfeiting.
Novel biocompatible NIR-II fluorophore with AIE characteristics has been developed and used for biomedical fluorescence imaging.
A new NIR fluorescent probe HBTP-S was developed for detection of hydrogen sulfide based on an excited state intramolecular proton transfer mechanism.
Abstract A novel fluorescent probe with a high quantum yield (0.41), large Stokes shifts (255 nm), and red emission (635 nm) was designed to detect all typical oxidation states of palladium species (0, +2, +4) by palladium‐mediated terminal propargyl ethers cleavage reaction in water solution without any organic media. The showed selectivity excellent sensitivity for species, detection as low 57 n M (6.2 μg L −1 ).
Manipulation of photophysical properties pure organic materials via simple alteration is attractive but extremely challenging because the lack valid design strategies for achieving ultralong afterglow or efficient room-temperature phosphorescence. Herein, we report a first manipulation ionic crystals from to highly phosphorescence by variation halides in crystals. Crystal structural analysis reveals tetraphenylphosphonium chloride promoted strong intermolecular electronic coupling crystal,...
The AP/Co<sub>3</sub>(CH<sub>3</sub>COO)<sub>5</sub>(OH) composites of the core–shell structure were prepared, safety and thermal decomposition properties AP improved simultaneously, possible catalytic mechanism was analyzed.