A5018648839- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Otolaryngology and Infectious Diseases
- Liver Disease Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Receptor Mechanisms and Signaling
- Cardiac tumors and thrombi
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Cancer-related molecular mechanisms research
- Sinusitis and nasal conditions
- Analytical Chemistry and Sensors
- Flavonoids in Medical Research
- Neurofibromatosis and Schwannoma Cases
- Intestinal and Peritoneal Adhesions
- Nanomaterials for catalytic reactions
- Enzyme function and inhibition
- Immune Response and Inflammation
- Lipid metabolism and disorders
- Cardiovascular Health and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Vascular Tumors and Angiosarcomas
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Northwestern Polytechnical University
2024
Fujian Medical University
2023-2024
National Clinical Research
2024
First Affiliated Hospital of Zhengzhou University
2011-2022
Zhengzhou University
2021
National Clinical Research Center for Digestive Diseases
2021
State Key Laboratory of Cardiovascular Disease
2021
Tengzhou Central People's Hospital
2019-2020
Fifth Affiliated Hospital of Zhengzhou University
2018
Non-coding RNAs (ncRNAs) have been reported to participate in tumor progression by regulating gene expression. Previous studies showed that protein phosphatase Mg2+/Mn2+ dependent 1F (PPM1F) acts a dual role cancer growth and metastasis. But, the underlying mechanisms which ncRNAs regulate PPM1F expression hepatocellular carcinoma (HCC) are poorly understood. The association between or miR-490-3p clinicopathological features prognosis patients with HCC was analyzed TCGA RNA-sequencing data....
Abstract Purpose: Fibroblast activation protein (FAP) is a promising target for tumor treatment. In this study, we aimed to investigate the safety and efficacy of albumin binder-conjugated FAP-targeted radiopharmaceutical, 177Lu-EB-FAPI (177Lu-LNC1004), in patients with metastatic radioiodine-refractory thyroid cancer (mRAIR-TC). Patients Methods: This open-label, non-randomized, first-in-human, dose-escalation, investigator-initiated trial had 3+3 design involved 6-week 177Lu-LNC1004...
Abstract Objectives This study aims to compare the achieved and predicted root movements in adults after four first‐premolar extractions Invisalign treatment. Materials Methods Thirty‐three consecutive (22 Class I, 9 Cusp‐to‐cusp II 2 III) from a single clinical division who completed first series of aligners premolar were included this retrospective study. A pretreatment cone‐beam computed tomography model was registered onto surface‐scanned dental (SSDM) locate apices whole dentition....
AIM:To investigate the ezrin expression in normal colorectal mucosa and cancer tissues, study correlation between tissues tumor invasion metastasis. METHODS:Eighty paraffin-embedded tissue samples were selected from primary adenocarcinoma.Twenty-eight patients had welldifferentiated, 22 moderately differentiated 30 poorly adenocarcinoma.Forty-five 35 lymph node metastasis.Forty-five of Dukes A to B stage, C D stage.Another blocks epithelium (> 5 cm away edge tumor) as control group.All with...
Peptide receptor radionuclide therapy (PRRT) with radiolabeled SSTR2 agonists is a treatment option that highly effective in controlling metastatic and progressive neuroendocrine tumors (NETs). Previous studies have shown an agonist combined albumin binding moiety Evans blue (denoted as 177Lu-EB-TATE) characterized by higher tumor uptake residence time preclinical models patients NETs. This study aimed to enhance the vivo stability, pharmacokinetics, pharmacodynamics of 177Lu-EB-TATE...
Background:The aim of this study was to establish the reference intervals (RIs) total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate transaminase (AST), and creatinine (CREA) for apparently healthy elderly (Han ethnicity) in Shuyang, China. Material/Methods:A 54 912 blood specimens from residents age 65-104 years were collected by standard procedures Shuyang county Jiangsu province.TBIL, ALT, AST, CREA each participant determined automatic biochemical analyzer.Distribution...
Hepatocellular carcinoma (HCC) results in large amounts of deaths each year worldwide. To develop more effective treatments for HCC, it is very necessary to define the molecular mechanisms hepatocarcinogenesis. Mixed lineage kinase (MLK)-4 a member MLK family mitogen-activated protein kinases, and modulates different cellular responses. However, its role meditation HCC progression remains unclear. In study, we found that MLK4 was over-expressed tumor samples patients. High expression...
Background: Lipoprotein(a) is positively related to cardiovascular events in patients with coronary artery disease (CAD). Given that lipoprotein(a) has a prothrombotic effect, prolonged dual antiplatelet therapy (DAPT) might have beneficial effect on reducing ischemic elevated levels after percutaneous intervention (PCI). We performed this study assess the efficacy and safety of DAPT (>1 year) population. Methods: evaluated total 3,025 CAD who were event-free at 1 year PCI from...
Water vapor and cloud liquid water influence the accuracy of altimeter measurements by delaying time that altimeter's signals travel from satellite to ocean surface back. Atmospheric correction microwave radiometer (ACMR) can be used measure radiation atmosphere earth's so as retrieve amount water. HY-2 is a Chinese for dynamic environmental monitoring. It launched on Aug.16, 2011. ACMR one payloads. The other payloads are an altimeter, scatterometer scanning radiometer. started work Sep.1,...
Cerebral venous sinus thrombosis (CVST) is a rare and devastating complication of inflammatory bowel disease (IBD). Early diagnosis prompt treatment could improve prognosis. The aim our study was to investigate the clinical data predictive factors in patients with CVST. All IBD patient were collected from July 2013 September 2020. Clinical data, prognosis compared between CVST control group. incidence 0.48%. mean age 34.9 years. average duration 4 years when cerebrovascular events occurred....
To evaluate the predictive value of fasting plasma glucose (FPG) for in-hospital mortality in patients with acute myocardial infarction (AMI) different metabolism status.
Two kinds of Schiff base metal complexes 2-hydroxy-1-naphthaldehyde-2-amino-5-phenylthiazole (HANPTS), Mn(II)(HNAPTS)2 and Fe(III)(HNAPTS)2, were synthesized used to mimic the active group horseradish peroxidase (HRP). The catalytic characteristics enzymes in oxidation reaction ascorbic acid (AsA) with OOH polyethylene glycols (PEGs) have been studied by a spectrophotometric method. Fe(III) has remarkable coordinated catalysis Mn(II)(HNAPTS)2; as result, ability Fe(III)-Mn(II)(HNAPTS)2 is...
Objective To evaluate the diagnosis and application values of endoscopic uhrasonography （EUS） with micro-probe in duodenal lesions. Methods Clinical data 37 patients lesions underwent EUS were analyzed retrospectively. All treated mucosal resection or surgical to get pathological diagnosis. The diagnostic accuracy microprobe biopsy was respectively. Results overall on 78.38% （29/37）, a higher rate lipoma 4/4 adenomas 10/12 than early cancer 2/4 inflammatory hyperplasia 3/8. 40. 54% （ 15/37）,...
Objective To explore the therapeutic effects and value of endoscopic variceal ligation tissue glue injection therapy in esophageal gastric fundal varices.Methods 184 patients with severe varices underwent treatment,and 32 cases those accompanied were treated therapy.All followed-up for 6-months to observe complication therapy.Results The effective rate was 71.74 ％ ( 132/184 ),the acute hemostasis 95.00％(57/60)and 2.17 (4/184).The 100％ (32/32) 21.88％ (7/32) (7 refractory ulcers site,2...
<div>AbstractPurpose:<p>Fibroblast activation protein (FAP) is a promising target for tumor treatment. In this study, we aimed to investigate the safety and efficacy of albumin binder-conjugated FAP-targeted radiopharmaceutical, <sup>177</sup>Lu-EB-FAPI (<sup>177</sup>Lu-LNC1004), in patients with metastatic radioiodine-refractory thyroid cancer (mRAIR-TC).</p>Patients Methods:<p>This open-label, non-randomized, first-in-human, dose-escalation,...
<p>Figure S1-S6, Table S1-S3</p>