A5100690883- Protein Hydrolysis and Bioactive Peptides
- Chemical Synthesis and Analysis
- Phytase and its Applications
- Antimicrobial Peptides and Activities
- Nanoplatforms for cancer theranostics
- Meat and Animal Product Quality
- Insect Utilization and Effects
- Proteins in Food Systems
- Click Chemistry and Applications
- Nutrition, Genetics, and Disease
- Aquaculture Nutrition and Growth
- Epigenetics and DNA Methylation
- Biochemical effects in animals
- Carbohydrate Chemistry and Synthesis
- RNA modifications and cancer
- Tannin, Tannase and Anticancer Activities
- Protein Kinase Regulation and GTPase Signaling
- Traditional and Medicinal Uses of Annonaceae
- Muscle metabolism and nutrition
- RNA and protein synthesis mechanisms
- Echinoderm biology and ecology
- Robotics and Sensor-Based Localization
- Plant Gene Expression Analysis
- Exercise and Physiological Responses
- Railway Systems and Energy Efficiency
University of Tsukuba
2025
Suizhou Central Hospital
2023-2025
Chengdu University of Traditional Chinese Medicine
2023-2025
Beijing Forestry University
2025
Technical University of Munich
2025
Sun Yat-sen University
2022-2023
Nanjing Agricultural University
2022-2023
Chongqing Medical University
2023
Zhejiang University
2023
Dalian Polytechnic University
2019-2022
Hypoxia, a ubiquitously aberrant phenomenon implicated in tumor growth, causes severe resistance to therapeutic interventions. Instead of the currently prevalent solution through intratumoral oxygen supply, we put forward an "O2-economizer" concept by inhibiting O2 consumption cell respiration spare endogenous and overcome hypoxia barrier. A nitric oxide (NO) donor responsible for inhibition photosensitizer photodynamic therapy (PDT) are co-loaded into poly(d,l-lactide- co-glycolide)...
Background: The application of deep generative models for molecular discovery has witnessed a significant surge in recent years. Currently, the field generation and optimization is predominantly governed by autoregressive regardless how data represented. However, an emerging paradigm domain diffusion models, which treat non-autoregressively have achieved breakthroughs areas such as image generation. Methods: potential capability tasks remain largely unexplored. In order to investigate...
Objectives: BT8009 is a chemically synthesized BTC® (~4.2 kDa) comprising small Nectin-4-targeting bicyclic peptide linked to cytotoxin MMAE. has been studied in dose-escalation (2.5 10 mg/m2 QW, Q2W, or on Days 1 and 8 of 21-day cycle) expansion Ph1/2 study (Duravelo-1, NCT04561362) patients with solid advanced malignancies, demonstrated preliminary antitumor activities an acceptable safety profile. We employed population PK (PopPK) exposure-safety (E-S) analyses Duravelo-1 inform selection...
Prunus mume is an ecologically and economically valuable plant with both medicinal edible values. However, drought severely limits the promotion cultivation of P. in arid semi-arid areas northern China. In this study, we treated 'Meiren' natural then assessed photosynthetic physiological indexes such as osmoregulatory substances, parameters, antioxidant enzyme activities. Furthermore, employed transcriptome sequencing to explore internal regulatory mechanism under stress. As stress...
Cyclic peptides, known for their high binding affinity and low toxicity, show potential as innovative drugs targeting "undruggable" proteins. However, therapeutic efficacy is often hindered by poor membrane permeability. Over the past decade, FDA has approved an average of one macrocyclic peptide drug per year, with romidepsin being only intracellular site. Biological experiments to measure permeability are time-consuming labor-intensive. Rapid assessment cyclic crucial development. In this...
Mei (Prunus mume Sieb. et Zucc.) is a rare woody species that flowers in winter, yet its large-scale propagation limited by the variable ability of cuttings to form adventitious roots (ARs). In this study, two cultivars were compared: P. ‘Xiangxue Gongfen’ (GF), which readily, and ‘Zhusha Wanzhaoshui’ (ZS), more recalcitrant. Detailed anatomical observations revealed following cutting, basal region expanded within 7 days, callus tissues had appeared 14 AR primordia emerged between 28 35...
Zinc absorption in intestinal system could be strongly affected by the gastrointestinal digestion and of zinc-chelating peptides serving as zinc carriers. In this study, a novel sea cucumber synthetic peptide (SCSP) was synthesized to estimate its promotive effect vitro.Analysis isothermal titration calorimetry suggested that binding SCSP (N ≈ 1) exothermic, with relatively weak affinity (K = 1.0 × 10-3 mol L-1 ). The formation SCSP-Zn complexes brought morphological changes confirmed...
Abstract BACKGROUND Zinc is known to play an essential role in the biological activities human body. In this study, a zinc‐chelating peptide (ZCP) produced by Alcalase‐assisted hydrolysis of body wall sea cucumber was isolated and identified. The ZCP purified stepwise ultrafiltration, anion‐exchange chromatography, gel filtration conjunction with ultraviolet–visual (UV–visual) spectrophotometry, which used analyze each fraction. RESULTS Analysis revealed that its ability 33.31%. isothermal...
In this study, three synthetic zinc-chelating peptides (ZCPs) derived from sea cucumber hydrolysates with limited or none of the common metal-chelating amino-acid residues were analyzed by flame atomic absorption spectroscopy, circular dichroism size exclusion chromatography, zeta-potential, Fourier transform infrared Raman spectroscopy and nuclear magnetic resonance spectroscopy. The amount zinc bound to ZCPs reached maximum values ZCP:zinc at 1:1, it was not further increased additional...
Phenolipids such as alkyl gallates (A-GAs) have been approved by food industry non-toxic antioxidant additives. However, their digestion and absorption mechanisms in the intestine not yet clarified. In this research, hydrolysis transport characteristics of A-GAs with fatty alcohols various chain lengths (C1:0, C2:0, C3:0, C4:0, C8:0, C12:0 C16:0) were estimated everted-rat-gut-sac model (ERGSM) for first time. High-performance liquid chromatography measurements proved that measurable peaks...
In our previous study, the antioxidant peptides (XHY69AP, AP-D, YPLP, and AGPL) were obtained from potential probiotic yeast (Yamadazyma triangularis XHY69), which was selected by lab dry-cured ham. This work aimed to explore effects of yeast-derived on skeletal muscle function fatigue. Results showed that up-regulated slow-twitch fiber expression down-regulated fast-twitch in C2C12 cells (p < 0.05). The improved mitochondrial membrane potential, adenosine triphosphate generation,...
Abstract Food digestion requires the cooperation of different digestive organs. The differentiation organs is crucial for larvae to start feeding. Therefore, during organogenesis, cell identity and tissue morphogenesis must be tightly coordinated but how this accomplished poorly understood. Here, we demonstrate that WD repeat domain 5 (Wdr5)-mediated H3K4 tri-methylation (H3K4me3) coordinately regulates differentiation, proliferation apoptosis in zebrafish organogenesis three major including...
Unprecedented Staudinger reaction modes of secondary phosphine oxides (SPO) and organic azides are herein disclosed. By the application various additives, selective nitrogen atom exclusion from azide group has been achieved. Chlorotrimethylsilane mediates a stereoretentive with 2-N which provides valuable method for synthesis phosphinic amides can be considered complementary to stereoinvertive Atherton-Todd reaction. Alternatively, 1-N pathway is promoted by acetic acid provide corresponding...
Zinc (Zn) is an essential catalytic element in the human health system but its absorption intestinal can be strongly affected by gastrointestinal (GI) digestion. In this study, food-derived potential Zn carrier, scallop adductor hydrolysates (SAHs), was produced and characterized.During temporary storage at 4 °C, SAH decreased Zn-chelating capacity aqueous phase, whereas SAH-Zn complex exhibited high stability. Moreover, secondary structure of had no significant alteration. morphologically...
Non-small cell lung cancer (NSCLC) is one of the main causes cancer-related death worldwide, with a serious impact on human health and life. The identification NSCLC at an early stage formidable task that frequently culminates in belated diagnosis. LncRNA kind noncoding RNA limited protein-coding capacity, its expression out balance many cancers, especially NSCLC. A large number studies have reported lncRNA acts vital role regulating angiogenesis, invasion, metastasis, proliferation...
Conventional Staudinger reductions of organic azides are sluggish with aryl or bulky aliphatic azides. In addition, reduction usually requires a large excess water to promote the decomposition aza-ylide intermediate into phosphine oxide and amine products. To overcome challenges above, we designed novel triaryl reagent 2c an ortho-SO2NH2 substituent. Herein, report that such reagents able mediate both alkyl in either anhydrous wet solvents. Good excellent yields were obtained all cases (even...
Depth estimation plays a pivotal role in autonomous driving, facilitating comprehensive understanding of the vehicle's 3D surroundings. Radar, with its robustness to adverse weather conditions and capability measure distances, has drawn significant interest for radar-camera depth estimation. However, existing algorithms process inherently noisy sparse radar data by projecting points onto image plane pixel-level feature extraction, overlooking valuable geometric information contained within...