A5107958757- Ammonia Synthesis and Nitrogen Reduction
- Catalytic Processes in Materials Science
- Nanomaterials for catalytic reactions
- RNA and protein synthesis mechanisms
- MXene and MAX Phase Materials
- RNA modifications and cancer
- Neural Networks and Applications
- Advanced Nanomaterials in Catalysis
- Sensor Technology and Measurement Systems
- Luminescence and Fluorescent Materials
- RNA Research and Splicing
- Bone Metabolism and Diseases
- Synthesis of Tetrazole Derivatives
- Copper-based nanomaterials and applications
- Nanoplatforms for cancer theranostics
- Statistical and numerical algorithms
- Advanced Photocatalysis Techniques
- Hydrogen Storage and Materials
- interferon and immune responses
- Ginger and Zingiberaceae research
- Multicomponent Synthesis of Heterocycles
- Kruppel-like factors research
- Industrial Gas Emission Control
- Food composition and properties
- Psoriasis: Treatment and Pathogenesis
Shenzhen Third People’s Hospital
2025
Yunnan Normal University
2025
Xiangya Hospital Central South University
2025
Zhejiang University
2013-2024
Jilin University
2024
China Jiliang University
2024
Guangdong Academy of Agricultural Sciences
2024
Beijing Jishuitan Hospital
2024
Capital Medical University
2024
Peking University
2024
ABSTRACT Periodontitis involves hyperactivated stromal cells that recruit immune cells, exacerbating inflammation. This study presents an ATP-responsive metal–organic framework (Mg/Zn-MOF) designed for periodontitis treatment, utilizing ion interference to modulate responses and prevent tissue destruction. Addressing the challenges of synergistic effects targeted delivery faced by traditional immunomodulatory nanomaterials, Mg/Zn-MOF system is activated extracellular ATP—a pivotal molecule...
Background: The application of deep generative models for molecular discovery has witnessed a significant surge in recent years. Currently, the field generation and optimization is predominantly governed by autoregressive regardless how data represented. However, an emerging paradigm domain diffusion models, which treat non-autoregressively have achieved breakthroughs areas such as image generation. Methods: potential capability tasks remain largely unexplored. In order to investigate...
This is a hospital-based, single-center, cross-sectional study to investigate the status quo of hyperuricaemia (HUA) in general adults Shenzhen, booming seaside city South China. All health (≥18 years old) undergoing examination from 2020 Oct 1 2021 September 30 hospital were enrolled. Their medical records investigated and analyzed. Total 4604 participants (2938 males 1756 females) included We found that although Shenzhen younger than people analogous adjacent cities (total 38.41 ± 10.33...
The primary challenge in molecular design and drug discovery lies efficiently exploring an immense chemical space (estimated between 1023 1060). scaffold serves as the core framework medicinal chemistry, guiding diversity assessment, conformational studies, hopping. While approximately 70% of approved drugs are based on known scaffolds, 98.6% ring-based scaffolds virtual libraries remain unvalidated. Traditionally, complexity ring systems, a crucial component has been assessed using index...
The primary challenge in molecular design and drug discovery lies efficiently exploring an immense chemical space (estimated between 1023 1060). scaffold serves as the core framework medicinal chemistry, guiding diversity assessment, conformational studies, hopping. While approximately 70% of approved drugs are based on known scaffolds, 98.6% ring-based scaffolds virtual libraries remain unvalidated. Traditionally, complexity ring systems, a crucial component has been assessed using index...
<b>Background: </b> Intracerebral hemorrhage (ICH) results in secondary brain edema and injury that may lead to death disability. ICH also causes inflammation. It is unclear whether inflammation contributes neuron or functions repairing the tissue. <b> Aims: To understand effect of ICH, we have carried out an investigation on various aspects dynamic changes Settings Design:</b> An model was generated by injecting 50 ml autologous tail artery blood stereotactically into right caudate nucleus...
Metal–support interactions, which are related to electronic metal–support interaction (EMSI), particle morphology, interfacial perimeter, and strong (SMSI), have a impact on the catalytic performance for ceria-supported metal catalysts. High-temperature hydrogen reduction can induce in Ru/CeO2 catalyst. However, this treatment under severe conditions would lead lowering of metallic Ru species because some be covered by Ce suboxides, is detrimental activity ammonia synthesis that required as...
Riboswitches are conserved non-coding domains in bacterial mRNA with gene regulation function that essential for maintaining enzyme co-factor metabolism. Recently, the pnuC RNA motif was reported to selectively bind nicotinamide adenine dinucleotide (NAD+), defining a novel class of NAD+ riboswitches (NAD+-II) according phylogenetic analysis. To reveal three-dimensional architecture and ligand-binding mode this riboswitch, we solved crystal structure NAD+-II riboswitch complex NAD+....
A two-dimensional Z-scheme Al-TCPP/In 2 S 3 heterojunction demonstrated an enhanced photocatalytic H O yield in pure water. Additionally, the film samples allowed for easy recovery from system and excellent stability.
In contrast to the high efficiency of room temperature phosphorescence in crystal states, generally utilized nanoparticles organic materials bioimaging demonstrated sharply decreased performance by orders magnitude under physiological conditions, badly limiting realization their unique advantages. This case, especially for red/near‐infrared (NIR) materials, is not only challenge present reality but more importantly, theoretical problem deeply understanding and avoiding quenching effect...
Abstract The design of an efficient non‐noble metal catalyst is burgeoning interest for ammonia synthesis. Herein, we report a Mo 2 C/CeO that superior in synthesis activity. In this catalyst, molybdenum carbide coexisted with the ceria overlayers which from support as strong metal–support interaction. There high proportion low‐valent species, well concentration Ce 3+ and surface oxygen species. presence C CeO not only leads to enhancement hydrogen nitrogen adsorption, but also facilitates...
A deep understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-host interactions is crucial to developing effective therapeutics and addressing the threat emerging coronaviruses. The role noncoding regions viral RNA (ncrRNAs) has yet be systematically scrutinized. We developed a method using MS2 affinity purification coupled with liquid chromatography-mass spectrometry designed diverse set bait ncrRNAs map interactome SARS-CoV-2 ncrRNA in Calu-3, Huh7, HEK293T cells....
Public transport plays an indispensable role in the whole public system. This paper makes in-depth study on how can provide passengers with higher service quality while meeting needs of passengers. In order to achieve this research goal, organically incorporates three key subjects government supervision, and into framework. Evolutionary game theory is used construct corresponding model. It has been found that decision-making behaviours regulators, are intricately intertwined influence each...
Abstract Chemical burns account for a small percentage of burn patients, and there are even fewer patients suffering from chemical combined with inhalation injury. As substances corrode the airway, which leads to persistent necrotic shedding respiratory mucosa scarring contracture as airway heals, proportion develop stenosis, requiring more aggressive treatment or surgery. A 38‐year‐old female factory worker sustained an injury due exposure reactive (liquid smoke) during production. She...
Abstract Background Animal models are indispensable tools in studying the cause of human diseases and searching for treatments. The scientific value an animal model depends on accurate mimicry diseases. primary goal current study was to develop a cross-species method by using models' expression data evaluate similarity diseases' assess drug molecules' efficiency research. Therefore, we hoped reveal that it is feasible useful compare gene profiles across species studies pathology, toxicology,...