A5100355093- Genetic and phenotypic traits in livestock
- Virus-based gene therapy research
- Genetic Mapping and Diversity in Plants and Animals
- CAR-T cell therapy research
- Plant Pathogens and Fungal Diseases
- Cancer-related molecular mechanisms research
- Mycotoxins in Agriculture and Food
- Horticultural and Viticultural Research
- Plant Molecular Biology Research
- Immunotherapy and Immune Responses
- Fermentation and Sensory Analysis
- Rangeland Management and Livestock Ecology
- Wheat and Barley Genetics and Pathology
- RNA Interference and Gene Delivery
- Genomic variations and chromosomal abnormalities
- CRISPR and Genetic Engineering
- Viral gastroenteritis research and epidemiology
- Mycorrhizal Fungi and Plant Interactions
- Cancer Research and Treatments
- Plant Reproductive Biology
- Plant Stress Responses and Tolerance
- High Altitude and Hypoxia
- Botanical Research and Applications
- Real-Time Systems Scheduling
- Skin and Cellular Biology Research
City University of Hong Kong
2025
Tarim University
2023-2024
State Forestry and Grassland Administration
2024
Yantai University
2021-2024
Xinjiang Production and Construction Corps
2023-2024
Ministry of Agriculture and Rural Affairs
2023
Guangzhou Medical University
2022
Michigan State University
2022
Institute of Microbiology
2022
Chinese Academy of Sciences
2022
Owing to the climate change impacts, waterlogging is one of most hazardous abiotic stresses crops, which also can result in a serious reduction quantity and quality grape berry wine production during rainy season. Therefore, exploration response mechanism necessary, for analysis transcriptomic regulation networks grapevine leaves stress was carried out. In this study, 12 634 genes were detected both control plants, out 6837 differentially expressed. A comparative revealed that functioning...
Sheep are important livestock animals that have evolved under various ecological pressures. Xinjiang is a region with diverse and harsh environments shaped many local sheep breeds unique characteristics environmental adaptability. However, these losing flexibility due to the promotion of intensive farming practices. Here we sequenced 14 from analyzed their genetic structure gene flow other neighboring regions. The Tibetan Plateau was geographic origin native evolution. We performed...
Two telomere-to-telomere, gap-free genome for Rubus species were sequenced and assembled by using an integrative approach that combined ultra-long reads from Oxford Nanopore Technology (ONT), PacBio high-fidelity (HiFi) long reads, Illumina paired-end short High-throughput Chromosome Conformation Capture (Hi-C) data, resulted in the first reference genomes of genus. By comparative genomics transcriptomics, we revealed conserved key genes associated with sugar accumulation genus, providing...
The microRNA171 (miR171) family is widely distributed and highly conserved in a range of species plays critical roles regulating plant growth development through repressing expression SCARECROW‐LIKE ( SCL ) transcription factors. However, information on the evolutionary conservation functional diversification miRNA171 members remains scanty. We reconstructed phylogenetic relationships among miR171 precursor mature sequences so as to investigate extent degree Arabidopsis thaliana (L.) Heynh....
Abstract Background Emerging evidence suggests the involvement of caudal-related homoeobox transcription factor 2 (CDX2) in tumorigenesis various cancers. Although CDX2 functions cancer invasion and metastasis, fewer studies focus on role during induction epithelial–mesenchymal transition (EMT) colorectal (CRC). Methods Immunohistochemical analysis was performed. A series vitro vivo experiments were conducted to reveal metastasis CRC. Results downregulated CRC tissues reduced correlated with...
Grapes are categorized as a non-climacteric type of fruit which its ripening is not associated to important rises in respiration and ethylene synthesis. The starch metabolism shares certain role the carbohydrate metabolic pathways during grape berry development, regarded an transient pool pathway sugar accumulation. However, comprehensive contribution quality flavor have been explored thoroughly. In this study, expression levels genes enzyme activities concentrations related metabolism, were...
Cancer immunotherapy is a new therapeutic strategy for cancer treatment that targets tumors by improving or restoring immune system function. Therapies targeting checkpoint molecules have exerted potent anti-tumor effects and prolonged the overall survival rate of patients. However, only small number patients benefit from treatment. Oncolytic viruses exert regulating tumor microenvironment affecting multiple steps circulation. In this study, we engineered two oncolytic express mouse...
Adaptation of insects to different altitudes remain largely unknown, especially those endemic the Tibetan Plateau (TP). Here, we generated transcriptomes Gynaephora menyuanensis and G. alpherakii, inhabiting high on TP, used these previously available transcriptomic genomic sequences from low-altitude explore potential genetic basis for divergent high-altitude adaptation in Gynaephora. An analysis 5,869 orthologous genes among other three uncovered that fast-evolving positively selected...
Contents Egg production is an important economic trait in poultry, and it of great significance to study the key genes functional SNPs that affect egg laying performance. Follicle‐stimulating hormone (FSH) plays physiological role reproductive performance humans animals by binding its receptor (FSHR). Studies have shown there are many transcriptional regulatory elements 5′ flanking region FSHR gene interact with transcription factors regulate transcription. In this study, DNA sequencing was...
Oncolytic virotherapy is emerging as a promising therapeutic avenue for cancer treatment, harnessing both innate and tumor-specific immune responses targeted tumor elimination. In this study, we present novel oncolytic virus (oHSV1-IL15B) derived from herpes simplex virus-1 (HSV-1), armed with IL-15/IL-15Rα complex, focus on treating colon combined HSV-1 expressing anti-PD-1 antibody (oHSV1-aPD1). Results our study reveal that recombinant oHSV-1 equipped complex exhibited significant...
Local sheep in the northeastern Tarim Basin can adapt to dry and low-rainfall regional environments. In this study, three local breeds Basin, LOP (LOP) sheep, Bayinbuluke (BYK) Kunlun (KUN, also known as Qiemo sheep) introduced breeds, Suffolk (SUF) Dorset (APD) Texel (TEX) were analyzed for genetic diversity, population structure, selective signature using Illumina OvineSNP50K BeadChip. We found that LOP, BYK, KUN had lower observed heterozygosity expected than TEX, SUF, ADP, which...
Alternaria gansuensis, a seed-borne fungus of standing milkvetch (Astragalus adsurgens), is the most common pathogen this plant species and causes yellow stunt root rot. Although resistance to disease has been identified, better understanding nature will help improve optimize its implementation in milkvetch. The effects A. gansuensis on physiology were assessed 4-week study comparing resistant variety, Shanxi, susceptible Ningxia. In first week, there was an obvious decrease photosynthesis...
Cervical mucus not only provides energy for sperm but also forms a barrier to block sperm. This paper aims study the microstructure of cervical in dairy cows during proestrus, estrus, and metestrus its effect on permeability. The experiment collected from 60 Holstein these phases, then observed different shapes after crystallization, classified mucus, analyzed proportions. Scanning electron microscopy was used observe ultrastructure measure micro-pore sizes, followed by permeability tests...
By assessing the genetic diversity and associated selective traits of Kirghiz sheep (KIR), we aim to uncover mechanisms that contribute sheep's adaptability Pamir Plateau environment.
Polyethyleneimine (PEI) is a well-known cationic polymer that has previously been shown to have significant potential deliver genes in vitro and vivo. However, PEI non-degradable exhibits high cytotoxicity as its molecular weight increases. The clinical application for systemic administration of adenoviral (Ad) vectors limited, these do not efficiently penetrate solid tumor masses due common deficiency Coxsackie Adenovirus Receptor (CAR) on the surface. In this study, we conjugated low (Mn =...
In order to study the influence of different types N fertilizers on grapevine (Vitis labruscana 'Black Summer') trees were used as experiment materials and foliar application trails conducted in flowering veraison stages. The expression levels five metabolic genes, including VvGHD, VvNiR, VvNR, VvGS VvAS, analyzed, some physiological traits flower fruit dropping rate, leaves shoots growth chlorophyll content size grape berry also investigated. results showed that, general, genes increased...