A5100384374- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Estrogen and related hormone effects
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Pharmacogenetics and Drug Metabolism
- Pharmacological Receptor Mechanisms and Effects
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- EEG and Brain-Computer Interfaces
- Drug Transport and Resistance Mechanisms
- Neurological Disease Mechanisms and Treatments
- Hypothalamic control of reproductive hormones
- RNA modifications and cancer
- Craniofacial Disorders and Treatments
- Genetics and Plant Breeding
- Barrier Structure and Function Studies
- Ion Transport and Channel Regulation
- RNA regulation and disease
- Genetics and Neurodevelopmental Disorders
- PI3K/AKT/mTOR signaling in cancer
- Metabolism and Genetic Disorders
- Ovarian function and disorders
Peking University
2024
Binzhou Medical University
2015-2023
The University of Texas Health Science Center at San Antonio
2017-2023
Huazhong Agricultural University
2023
Chongqing Medical University
2023
Binzhou University
2015-2023
Children's Hospital of Chongqing Medical University
2023
Yantai University
2022
Zhejiang University
2020
Central South University
2017
Abstract Norepinephrine adjusts sensory processing in cortical networks and gates plasticity enabling adaptive behavior. The actions of norepinephrine are profoundly altered by recreational drugs like ethanol, but the consequences these changes on distinct targets such as astrocytes, which exhibit norepinephrine-dependent Ca 2+ elevations during vigilance, not well understood. Using vivo two-photon imaging, we show that locomotion-induced mouse astroglia inhibited an effect can be reversed...
The clinical-stage agonists for trace amine-associated receptor 1 (TAAR1) show insufficient clinical efficacy, requiring the design of new compounds beyond TAAR1 alone. Here, we provide evidence feasibility designing TAAR1/5-HT2CR dual based on structural basis these two targets and similarities their agonists. Three series novel were discovered, leading to a potent compound named 21b. 21b exhibits submicromolar potency both 5-HT2CR with high specificity confirmed by site-directed...
Indoleamine 2,3-dioxygenase (IDO) is involved in tumor immune escape and resistance to chemotherapy, clinically correlated with progression. IDO inhibitors show marginal efficacy as single agents; therefore, combinations of these other therapies hold promise for cancer therapy. The aim this study was investigate the synergistic antitumor effects inhibitor NLG919 combination different regimens paclitaxel a murine B16-F10 melanoma model. increased cytotoxic activity toward cells presence...
The purposes of this study are to investigate the antitumor activities NSK-01105, a novel sorafenib derivative, in vitro and vivo models, explore potential mechanisms. effects NSK-01105 on proliferation apoptosis prostate cancer cells were established by cytotoxicity assays, analysis, flow cytometry Western blot analysis. Two xenograft tumor models used verify therapeutic effect vivo. exhibited broad-spectrum activity, particularly cells. Characterization morphology was observed, percentage...
Abstract Background Sepsis-induced cardiomyopathy (SIC) is a cardiac dysfunction caused by sepsis, with mitochondrial being critical contributor. Pyruvate dehydrogenase kinase 4 (PDK4) of pyruvate multifaceted actions in metabolism. However, its role SIC remains unknown. Methods Serum PDK4 levels were measured and analyzed 27 children SIC, 30 29 healthy children. In addition, for mice exhibiting the effects knockdown or inhibition on function structure myocardium mitochondria assessed....
Tris-(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO), an emerging brominated flame retardant, possesses the characteristics of candidate persistent organic pollutants and has displayed toxicity to fish rodents. TDBP-TAZTO can pass through blood brain barrier accumulate in brain. However, neurotoxicity not yet studied We hypothesize that could induce rat hippocampal neurons. The male adult rats were exposed 5 50 mg/kg by gavage, daily for 6 months. resulted cognitive impairment depression-like...
[Figure: see text].
In recent years it has become increasingly clear that astrocytes play a much more active role in neural processes than the traditional view of them as supporting cells suggests. Although not electrically excitable, exhibit diverse Ca2+ dynamics across spatial and temporal scales, or less dependent on animal's behavioral state. range from global elevations lasting multiple seconds encompassing soma up to finest processes, short restricted so-called microdomains within fine processes....
Significance How the loss of FMRP affects nonneuronal glial development especially underlying mechanisms remains essentially unexplored. By employing astroglial Fmr1 conditional knockout (cKO) mice and human FMRP-deficient astroglia, in current study, we showed that cell-autonomously up-regulates brain enriched miR-128-3p mouse which selectively disrupts developmental (but not neuronal) mGluR5 signaling. Subsequent transcriptome proteome profiling from vivo isolated astroglia further...
Abstract Behavioral state plays an important role in determining astroglia Ca 2+ signaling. In particular, locomotion‐mediated elevated vigilance has been found to trigger norepinephrine‐dependent whole cell elevations throughout the brain. For cerebellar Bergmann glia it recently that locomotion‐induced transient depend on their α 1A ‐adrenergic receptors. With increasing availability and implementation of locomotion as behavioral parameter becomes understand constraints noradrenergic...
Tryptophan (Trp) and kynurnine (Kyn) are a pair of biomarkers for indoleamine 2,3-dioxygenase which closely related to the tumor immune escape. To evaluate effect drugs on activity, specific accurate LC-MS/MS methods were developed validated simultaneous determination Kyn Trp in mouse plasma tissues using surrogate analytes Kyn-d4 Trp-d5 calibrators.Plasma homogenates samples pretreated with solid phase extraction assured method having high recovery (>90% >80% tumor) no matrix effect. The...
Introduction: Schizophrenia is a serious mental illness that requires effective treatment with minimal adverse effects. As preclinical and clinical research progresses, trace amine-associated receptor 1 (TAAR1) becoming potential new target for the of schizophrenia. Methods: We used molecular docking dynamics (MD) simulations to discover TAAR1 agonists. The agonistic or inhibitory effects compounds on TAAR1, 5-HT1A, 5-HT2A, dopamine D2-like receptors were determined. an MK801-induced...
Opiates produce analgesia via G-protein signaling, and adverse effects, such as respiratory depression decreased bowel motility, by β-arrestin pathway. Oliceridine, a G protein-biased MOR agonist, only presents modest safety advantages compared to other opiates in clinical trials, possibly due its limited bias. Our previous study shown that LPM3480392, full biased is selective for the Gi pathway over β-arrestin-2. In present article, we evaluated subacute toxicity of LPM3480392 rats. The...
Abstract Blood-brain barrier (BBB) impairment, which causes leakage of harmful peripheral substances into the brain, is an early indicator Alzheimer’s disease (AD). Microglia are known to regulate BBB integrity, but underlying mechanisms this process remain unclear. We here analyzed permeability and structural integrity in mice. Loss TREM2 function was found impair BBB; TREM2-deficient microglia showed CCL2 upregulation via activation NFκB pathway. The CCL2-CCR2 axis reduced expression...
Valbenazine and deutetrabenazine are the only two therapeutic drugs approved for tardive dyskinesia based on blocking action of vesicular monoamine transporter 2 (VMAT2). But there exist demethylated inactive metabolism at nine position both them resulting in low availability, CYP2D6 plays a major role this genetic polymorphism issue. 9-trifluoroethoxy-dihydrotetrabenazine (13e) was identified as promising lead compound treating dyskinesia. In study, we separated 13e via chiral...
Abstract Behavioral state plays an important role in determining astroglia Ca 2+ signaling. In particular, locomotion-mediated elevated vigilance has been found to trigger norepinephrine-dependent whole cell elevations throughout the brain. For cerebellar Bergmann glia it recently that locomotion-induced transient depend on their α 1A -adrenergic receptors. With increasing availability and implementation of locomotion as behavioral parameter becomes understand constraints noradrenergic...